Vitamin D and Alzheimer's Disease

Yıl 2018, Cilt: 4 Sayı: 2, 980 - 991, 15.08.2018

Murat Açık Nurcan Yabancı Ayhan

https://doi.org/10.30569/adiyamansaglik.415027

Cited By: 1

Öz

Vitamin
D, known for its effects on calcium homeostasis and bone health, is one of
nutrients whose deficiency is the most common in the world. In recent studies,
the presence of vitamin D receptors in many parts of the brain suggests that
this vitamin may have neurological effects. Vitamin D has many functions such
as cell differentiation, a regulatory effect on neurotrophic factors and
cytokines, neurotransmitter synthesis task and antioxidant activation.
Cognitive impairment, an important indicator of Alzheimer's disease, has been
associated with increased vitamin D deficiency with age. In this review
article, the functions of vitamin D in the brain, the pathological findings of
Alzheimer's disease and the effects on cognitive damage in the case of vitamin
D deficiency or supplementation are explained in the context of relevant literature. 

Anahtar Kelimeler

Alzheimer's disease, Vitamin D, Vitamin D receptors

D Vitamini ve Alzheimer Hastalığı

Öz

Kalsiyum homeostazı ve kemik sağlığı üzerindeki
etkileri bilinen D vitamini, dünyada yetersizliği en fazla görülen besin
ögelerinden biridir. Son yıllarda yapılan çalışmalarda, beynin birçok bölümünde
D vitamini reseptörlerinin bulunması bu vitaminin nörolojik etkilerinin
olabileceğini düşündürmektedir. D vitaminin hücre farklılaşması, nörotrofik
faktör ve sitokinler üzerinde düzenleyici, nörotransmitter sentez görevi ve
antioksidan aktivasyonu gibi birçok fonksiyonu bulunmaktadır. Alzheimer
hastalığının önemli bir göstergesi olan kognitif hasar yaşla beraber artan D
vitamini eksikliği ile ilişkili bulunmuştur. Bu derleme makalede, güncel
literatür eşliğinde, D vitaminin beyin üzerindeki işlevleri, D vitamini
yetersizliği veya takviyesi durumunda Alzheimer hastalığının patolojik
bulguları ve kognitif hasar üzerindeki etkileri açıklanmıştır. 

Anahtar Kelimeler

Alzheimer hastalığı, D vitamini, D vitamin reseptörleri

Kaynakça

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