Is there any association between ABO blood types and slow coronary flow?

Yıl 2019, Cilt: 5 Sayı: 2, 1492 - 1499, 15.08.2019

Hakan Kaya

https://doi.org/10.30569/adiyamansaglik.552822

Öz

Aim: Slow coronary
flow (SCF) is defined as a microvascular disorder characterized by slow advance
of the contrast material administered during angiography, despite absence of
epicardial coronary artery occlusion and delayed opacification of distal
vascular structures. Genetically inherited ABO blood types are presumed to play
role in coronary artery disease. In this study, the relationship between SCF
and ABO blood types was investigated.

Methods: The study
was designed as a retrospective study, and included 250 cases that underwent
coronary angiography procedure in our center between 2016 January and 2018
December (one hundred and twenty five cases of SCF and 125 cases of normal
coronary angiogram). ABO blood types were determined using standard
agglutination techniques in both study groups. Blood types were compared
between both subject groups.

Results: The
frequency of blood type A was increased among patients with SCF in comparison
with control subjects (p<0.001). High density lipoprotein cholesterol was
increased in SCF group (p<0.001). Triglyceride, , total cholesterol and low
density lipoprotein cholesterol levels were 
increased in the SCF group when compared to controls (p=0.003,
p<0.001, and p<0.001, respectively).

Anahtar Kelimeler

ABO blood types, slow coronary flow, Cardiology

Is there any association between ABO blood types and slow coronary flow?

Öz

Amaç: Koroner yavaş akım (KYA), epikardiyal
koroner arter tıkanıklığı olmamasına rağmen, anjiyografi sırasında uygulanan kontrast
maddenin yavaş ilerlemesi ve distal vasküler yapıların gecikmeli opaklaşması
ile karakterize bir mikrovasküler bozukluk olarak tanımlanmaktadır Genetik olarak
taşınan ABO kan gruplarının koroner arter hastalığında rol oynadığı
varsayılmaktadır. Bu çalışmada KYA ve ABO kan grupları arasındaki ilişki
araştırıldı.

Gereç
ve yöntemler:  Çalışma retrospektif bir çalışma olarak
tasarlandı ve merkezimizde Ocak 2016 - Aralık 2018 tarihleri ​​arasında koroner
anjiyografi prosedürü uygulanan 250 vaka (125 KYA hastası ve 125 normal koroner
anjiyogram vakası) çalışmaya dahil edildi. Her iki çalışma
grubunda da ABO kan tipleri standart aglütinasyon teknikleri kullanılarak
belirlendi. Her iki grup arasında kan tipleri karşılaştırıldı.

Bulgular: KYA hastalarında A kan grubu sıklığı
kontrol grubuna kıyasla artmıştı (p<0.001). 
Kontol grubunda yüksek dansiteli lipoprotein kolesterol artmıştı (p<0.001).
Kontrol grubuna kıyasla trigliserit, total kolesterol ve düşük dansiteli lipoprotein
kolesterol düzeyleri KYA grubunda artmıştı ( 
p =0.003, p<0.001, p<0.001, sırasıyla).

Sonuç: Bu çalışma, A kan grubunun KYA için artmış
bir risk olabileceğini ortaya koydu.

Anahtar Kelimeler

ABO kan grupları, koroner yavaş akım, kardiyoloji

Kaynakça

• 1. S. Xia, S. B. Deng, Y. Wang et al: Clinical analysis of the risk factors of slow coronary flow. Heart Vessels 2011; 26: 480–486
• 2. Pekdemir H, Cin VG, Cicek D, et al: Slow coronary flow may be a sign of diffuse atherosclerosis. Contribution of FFR and IVUS. Acta Cardiol 2004; 59: 127-133.
• 3. Van Lierde J, Vrolix M, Sionis D, et al: Lack of evidence for small vessel disease in a patient "with slow dye progression " in the coronary arteries. Cathet Cardiovasc Diagn 1991; 23: 117-120.
• 4. Madak N, Nazlı Y, Mergen H, et al: T.Acute phase reactants in patients with coronary slow flow phenomenon. Anadolu Kardiyol Derg 2010; 10: 416-420.
• 5. I. Barutcu, A. T. Sezgin, H. Gullu, et al: Slow coronary flow phenomenon associated with exercise-induced myocardial ischemia. Turkish Journal of thoracic and Cardiovascular Surgery 2005; 13: 295–297.
• 6. L. A. Cesar, J. A. Ramires, C. V. Serrana Junior et al: Slow coronary runoff in patient with angina pectoris: clinical significance and thallium-201 scintigraphic study. Brazilian Journal of Medical and Biological Research 1996; 29: 605–613.
• 7. Eastlund T: The histo‐blood group ABO system and tissue transplantation. Transfusion 1998; 38: 975–988.
• 8. Carpeggiani C, Coceani M, Landi P, et al: ABO blood group alleles: a risk factor for coronary artery disease. An angiographic study. Atherosclerosis 2010; 211: 461-466.
• 9. Zhang H, Mooney CJ, Reilly MP. ABO blood groups and cardiovascular diseases. Int J Vasc Med 2014; 58: 524-528.
• 10. Biancari F, Satta J, Pokela R, et al: ABO blood group distribution and severity of coronary artery disease among patients undergoing coronary artery bypass surgery in Northern Finland. Thromb Res 2002; 108: 195-196.
• 11. Gibson CM, Cannon CP, Daley WL, et al: TIMI frame count: a quantitative method of assessing coronary artery flow. Circulation 1996; 93: 879-888.
• 12. Hsin-Fu Lee, Yen-Chen Lin, Chia-Pin Lin, et al: Association of Blood Group A with Coronary Artery Disease in Young Adults in Taiwan. Intern Med 2012; 51: 1815-1820.
• 13. Ahmet Kaya, İbrahim Halil Tanboga, Mustafa Kurt, et al: Relation of ABO blood groups to coronary lesion complexity in patients with stable coronary artery disease. Anatol J Cardiol 2014; 14: 55-60.
• 14. V. Oktay and A. Arat Ozkan: Coronary slow flow. Turk Kardiyoloji Dernegi Arsivi-Archives of the Turkish Society of Cardiology 2016; 44: 193–195.
• 15. Elsherbiny IA: Left ventricular function and exercise capacity in patients with slow coronary flow. Echocardiography 2012; 29: 158-164.
• 16. Acikel S, Bozkaya OA, Akdemir R: The relationship between intermittent left bundle-branch block and slow coronary flow in a patient presenting with acute coronary syndrome. Blood Coagul Fibrinolysis 2010; 21: 595-597.
• 17. Kosus A, Sagkan O, Dursun I: Heart rate variability and QT dispersion in patients with slow coronary flow. Turk Kardiyol Dern Ars 2004; 32: 10-15.
• 18. Saya S, Hennebry TA, Lozano P, et al: Coronary slow flow phenomenon and risk for sudden cardiac death due to ventricular arrhythmias: a case report and review of literature. Clin Cardiol 2008; 31: 352-355.
• 19. Atak R, Turhan H, Sezgin AT, et al: Effects of slow coronary artery flow on QT interval duration and dispersion. Ann Noninvasive Electrocardiol 2003; 8: 107-111.
• 20. L agrand W K, V isser C A, H ermens W T, et al: C-reactive protein as a cardiovascular risk factor: more than an epiphenomenon? Circulation 1999; 100: 96 –102.