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The protective role of resveratrol against zinc oxide induced nanotoxicity

Yıl 2017, Cilt: 1 Sayı: 2, 21 - 25, 30.11.2017
https://doi.org/10.30616/ajb.343665

Öz

Zinc oxide (ZnO) is a compound
that has harmful effects as well as being used in many different areas.
Numerous studies have been carried out to minimize the toxic effects of ZnO
nanoparticles (NPs). In the present study, the protective role of
resveratrol (RSV), a potent antioxidant polyphenol substance, was examined
against ZnO-induced nanotoxicity on
human
pulmonary alveolar epithelial cells
(HPAEpiC). In
this context, the cytotoxic and genotoxic effects of different concentrations
of RSV (5, 10, 20 mg/L) and ZnO NPs on the cells were measured alone
and in combination
. At the same time, the effects of aforementioned
applications on the total antioxidant capacity (TAC) level in
HPAEpiC were
assessed. The results obtained showed that ZnO NPs alone significantly
increased cytotoxicity and genotoxicity on cells compared to negative control
(control (-)). In the experiments performed with RSV + ZnO NP combination,
cytotoxic and genotoxic activity decreased at the level of p < 0.05 especially at 20 mg/L application of RSV.
When
the level of TAC in cells was examined, a concentration-dependent increase was
detected between TAC and RSV. It was determined that Zno NPs reduced the TAC
level statistically (p
< 0.05) in comparison with control (-). In conclusion, the present study
revealed that RSV, a natural antioxidant, showed protective property against
genotoxic and cytotoxic damage induced by ZnO NPs on
HPAEpiC.

Kaynakça

  • Birben E, Sahiner UM, Sackesen C, Erzurum S, Kalayci O (2012). Oxidative Stress and Antioxidant Defense. World Allergy Organ J 5: 9–19.
  • Bonner JC (2010). Nanoparticles as a Potential Cause of Pleural and Interstitial Lung Disease. Proc Am Thorac Soc 7: 138–141.
  • Brown DM, Wilson MR, MacNee W, Stone V, Donaldson K (2001). Size-Dependent Proinflammatory Effects of Ultrafine Polystyrene Particles: A Role for Surface Area and Oxidative Stress in the Enhanced Activity of Ultrafines. Toxicol Appl Pharmacol 175: 191–199.
  • Carter LG, D’Orazio JA, Pearson KJ (2014). Resveratrol and Cancer: Focus on In Vivo Evidence. Endocr Relat Cancer 21: R209–R225.
  • Dogan M, Emsen B, Aasim M, Yildirim E (2017). Ceratophyllum demersum L. Extract as a Botanical Insecticide for Controlling the Maize Weevil, Sitophilus zeamais Motschulsky (Coleoptera: Curculionidae). Egypt J Biol Pest Control 27: 11–15.
  • Donaldson K, Murphy FA, Duffin R, Poland CA (2010). Asbestos, Carbon Nanotubes and the Pleural Mesothelium: A Review and the Hypothesis Regarding the Role of Long Fibre Retention in the Parietal Pleura, Inflammation and Mesothelioma. Part Fibre Toxicol 7: 5.
  • Dwivedi PD, Misra A, Shanker R, Das M (2009). Are Nanomaterials a Threat to the Immune System? Nanotoxicology 3: 19–26.
  • Elavarasan N, Kokila K, Inbasekar G, Sujatha V (2017). Evaluation of Photocatalytic Activity, Antibacterial and Cytotoxic Effects of Green Synthesized ZnO Nanoparticles by Sechium edule Leaf Extract. Res Chem Intermed 43: 3361–3376.
  • Emsen B, Dogan M, Aasim M, Yildirim E (2016). Insecticidal Activity of In Vitro Propagated Aquatic Plant Ceratophyllum demersum L. against Granary Weevil Sitophilus granarius L. (Coleoptera: Curculionidae). Egypt J Biol Pest Control 26: 619–624.
  • Emsen B, Turkez H, Togar B, Aslan A (2017). Evaluation of Antioxidant and Cytotoxic Effects of Olivetoric and Physodic Acid in Cultured Human Amnion Fibroblasts. Hum Exp Toxicol 36: 376–385.
  • Fröhlich E, Salar-Behzadi S (2014). Toxicological Assessment of Inhaled Nanoparticles: Role of In Vivo, Ex Vivo, In Vitro, and in Silico Studies. Int J Mol Sci 15: 4795–4822.
  • Ghorbani H, Mehr F, Pazoki H, Rahmani B (2015). Synthesis of ZnO Nanoparticles by Precipitation Method. Orient J Chem 31: 1219–1221.
  • Glauert HP, Tharappel JC, Lu Z, Stemm D, Banerjee S, Chan LS, Lee EY, Lehmler HJ, Robertson LW, Spear BT (2008). Role of Oxidative Stress in the Promoting Activities of PCBs. Environ Toxicol Pharmacol 25: 247–250.
  • Han Z, Yan Q, Ge W, Liu Z-G, Gurunathan S, De Felici M, Shen W, Zhang X-F (2016). Cytotoxic Effects of ZnO Nanoparticles on Mouse Testicular Cells. Int J Nanomedicine 11: 5187–5203.
  • Hao L, Wan Y, Xiao J, Tang Q, Deng H, Chen L (2017). A Study of Sirt1 Regulation and the Effect of Resveratrol on Synoviocyte Invasion and Associated Joint Destruction in Rheumatoid Arthritis. Mol Med Rep 16: 5099–5106.
  • Karatas M, Dogan M, Emsen B, Aasim M (2015). Determination of In Vitro Free Radical Scavenging Activities of Various Extracts from In Vitro Propagated Ceratophyllum demersum L.. Fresenius Environ Bull 24: 2946–2952.
  • Kendall M, Holgate S (2012). Health Impact and Toxicological Effects of Nanomaterials in the Lung. Respirology 17: 743–758.
  • King RE, Bomser JA, Min DB (2006). Bioactivity of Resveratrol. Compr Rev Food Sci Food Saf 5: 65–70.
  • Kononenko V, Repar N, Marušič N, Drašler B, Romih T, Hočevar S, Drobne D (2017). Comparative In Vitro Genotoxicity Study of ZnO Nanoparticles, ZnO Macroparticles and ZnCl 2 to MDCK Kidney Cells: Size Matters. Toxicol Vitr 40: 256–263.
  • Moezzi A, McDonagh AM, Cortie MB (2012). Zinc Oxide Particles: Synthesis, Properties and Applications. Chem Eng J 185–186: 1–22.
  • Oztetik E, Aydin E, Sonmez E, Aydin N, Turkez H (2017). Molecular Genetic Responses in Different Human Primary Cell Cultures Exposed to Aluminum–Zinc Oxide Based Nanoparticles In Vitro. J Biotechnol 256: S34–S35.
  • Özgür Ü, Alivov YI, Liu C, Teke A, Reshchikov MA, Doǧan S, Avrutin V, Cho SJ, Morko̧ H (2005). A Comprehensive Review of ZnO Materials and Devices. J Appl Phys 98: 1–103.
  • Roshini A, Jagadeesan S, Cho Y, Lim J, Choi K (2017). Synthesis and Evaluation of the Cytotoxic and Anti-Proliferative Properties of ZnO Quantum Dots against MCF-7 and MDA-MB-231 Human Breast Cancer Cells. Mater Sci Eng C 81: 551–560.
  • Savouret JF, Quesne M (2002). Resveratrol and Cancer: A Review. Biomed Pharmacother 56: 84–87.
  • Tourinho PS, van Gestel CAM, Lofts S, Svendsen C, Soares AMVM, Loureiro S (2012). Metal-Based Nanoparticles in Soil: Fate, Behavior, and Effects on Soil Invertebrates. Environ Toxicol Chem 31: 1679–1692.
  • Turkez H, Geyikoglu F, Yousef MI (2016a). Ameliorative Effects of Docosahexaenoic Acid on the Toxicity Induced by 2,3,7,8-Tetrachlorodibenzo-P-Dioxin in Cultured Rat Hepatocytes. Toxicol Ind Health 32: 1074–1085.
  • Turkez H, Sonmez E, Di Stefano A, Mokhtar YI (2016b). Health Risk Assessments of Lithium Titanate Nanoparticles in Rat Liver Cell Model for Its Safe Applications in Nanopharmacology and Nanomedicine. Cytotechnology 68: 291–302.
  • Xia T, Kovochich M, Liong M, Mädler L, Gilbert B, Shi H, Yeh JI, Zink JI, Nel AE (2008). Comparison of the Mechanism of Toxicity of Zinc Oxide and Cerium Oxide Nanoparticles Based on Dissolution and Oxidative Stress Properties. ACS Nano 2: 2121–2134.
  • Zhao J, Castranova V (2011). Toxicology of Nanomaterials Used in Nanomedicine. J Toxicol Environ Heal - Part B Crit Rev 14: 593–632.
Yıl 2017, Cilt: 1 Sayı: 2, 21 - 25, 30.11.2017
https://doi.org/10.30616/ajb.343665

Öz

Kaynakça

  • Birben E, Sahiner UM, Sackesen C, Erzurum S, Kalayci O (2012). Oxidative Stress and Antioxidant Defense. World Allergy Organ J 5: 9–19.
  • Bonner JC (2010). Nanoparticles as a Potential Cause of Pleural and Interstitial Lung Disease. Proc Am Thorac Soc 7: 138–141.
  • Brown DM, Wilson MR, MacNee W, Stone V, Donaldson K (2001). Size-Dependent Proinflammatory Effects of Ultrafine Polystyrene Particles: A Role for Surface Area and Oxidative Stress in the Enhanced Activity of Ultrafines. Toxicol Appl Pharmacol 175: 191–199.
  • Carter LG, D’Orazio JA, Pearson KJ (2014). Resveratrol and Cancer: Focus on In Vivo Evidence. Endocr Relat Cancer 21: R209–R225.
  • Dogan M, Emsen B, Aasim M, Yildirim E (2017). Ceratophyllum demersum L. Extract as a Botanical Insecticide for Controlling the Maize Weevil, Sitophilus zeamais Motschulsky (Coleoptera: Curculionidae). Egypt J Biol Pest Control 27: 11–15.
  • Donaldson K, Murphy FA, Duffin R, Poland CA (2010). Asbestos, Carbon Nanotubes and the Pleural Mesothelium: A Review and the Hypothesis Regarding the Role of Long Fibre Retention in the Parietal Pleura, Inflammation and Mesothelioma. Part Fibre Toxicol 7: 5.
  • Dwivedi PD, Misra A, Shanker R, Das M (2009). Are Nanomaterials a Threat to the Immune System? Nanotoxicology 3: 19–26.
  • Elavarasan N, Kokila K, Inbasekar G, Sujatha V (2017). Evaluation of Photocatalytic Activity, Antibacterial and Cytotoxic Effects of Green Synthesized ZnO Nanoparticles by Sechium edule Leaf Extract. Res Chem Intermed 43: 3361–3376.
  • Emsen B, Dogan M, Aasim M, Yildirim E (2016). Insecticidal Activity of In Vitro Propagated Aquatic Plant Ceratophyllum demersum L. against Granary Weevil Sitophilus granarius L. (Coleoptera: Curculionidae). Egypt J Biol Pest Control 26: 619–624.
  • Emsen B, Turkez H, Togar B, Aslan A (2017). Evaluation of Antioxidant and Cytotoxic Effects of Olivetoric and Physodic Acid in Cultured Human Amnion Fibroblasts. Hum Exp Toxicol 36: 376–385.
  • Fröhlich E, Salar-Behzadi S (2014). Toxicological Assessment of Inhaled Nanoparticles: Role of In Vivo, Ex Vivo, In Vitro, and in Silico Studies. Int J Mol Sci 15: 4795–4822.
  • Ghorbani H, Mehr F, Pazoki H, Rahmani B (2015). Synthesis of ZnO Nanoparticles by Precipitation Method. Orient J Chem 31: 1219–1221.
  • Glauert HP, Tharappel JC, Lu Z, Stemm D, Banerjee S, Chan LS, Lee EY, Lehmler HJ, Robertson LW, Spear BT (2008). Role of Oxidative Stress in the Promoting Activities of PCBs. Environ Toxicol Pharmacol 25: 247–250.
  • Han Z, Yan Q, Ge W, Liu Z-G, Gurunathan S, De Felici M, Shen W, Zhang X-F (2016). Cytotoxic Effects of ZnO Nanoparticles on Mouse Testicular Cells. Int J Nanomedicine 11: 5187–5203.
  • Hao L, Wan Y, Xiao J, Tang Q, Deng H, Chen L (2017). A Study of Sirt1 Regulation and the Effect of Resveratrol on Synoviocyte Invasion and Associated Joint Destruction in Rheumatoid Arthritis. Mol Med Rep 16: 5099–5106.
  • Karatas M, Dogan M, Emsen B, Aasim M (2015). Determination of In Vitro Free Radical Scavenging Activities of Various Extracts from In Vitro Propagated Ceratophyllum demersum L.. Fresenius Environ Bull 24: 2946–2952.
  • Kendall M, Holgate S (2012). Health Impact and Toxicological Effects of Nanomaterials in the Lung. Respirology 17: 743–758.
  • King RE, Bomser JA, Min DB (2006). Bioactivity of Resveratrol. Compr Rev Food Sci Food Saf 5: 65–70.
  • Kononenko V, Repar N, Marušič N, Drašler B, Romih T, Hočevar S, Drobne D (2017). Comparative In Vitro Genotoxicity Study of ZnO Nanoparticles, ZnO Macroparticles and ZnCl 2 to MDCK Kidney Cells: Size Matters. Toxicol Vitr 40: 256–263.
  • Moezzi A, McDonagh AM, Cortie MB (2012). Zinc Oxide Particles: Synthesis, Properties and Applications. Chem Eng J 185–186: 1–22.
  • Oztetik E, Aydin E, Sonmez E, Aydin N, Turkez H (2017). Molecular Genetic Responses in Different Human Primary Cell Cultures Exposed to Aluminum–Zinc Oxide Based Nanoparticles In Vitro. J Biotechnol 256: S34–S35.
  • Özgür Ü, Alivov YI, Liu C, Teke A, Reshchikov MA, Doǧan S, Avrutin V, Cho SJ, Morko̧ H (2005). A Comprehensive Review of ZnO Materials and Devices. J Appl Phys 98: 1–103.
  • Roshini A, Jagadeesan S, Cho Y, Lim J, Choi K (2017). Synthesis and Evaluation of the Cytotoxic and Anti-Proliferative Properties of ZnO Quantum Dots against MCF-7 and MDA-MB-231 Human Breast Cancer Cells. Mater Sci Eng C 81: 551–560.
  • Savouret JF, Quesne M (2002). Resveratrol and Cancer: A Review. Biomed Pharmacother 56: 84–87.
  • Tourinho PS, van Gestel CAM, Lofts S, Svendsen C, Soares AMVM, Loureiro S (2012). Metal-Based Nanoparticles in Soil: Fate, Behavior, and Effects on Soil Invertebrates. Environ Toxicol Chem 31: 1679–1692.
  • Turkez H, Geyikoglu F, Yousef MI (2016a). Ameliorative Effects of Docosahexaenoic Acid on the Toxicity Induced by 2,3,7,8-Tetrachlorodibenzo-P-Dioxin in Cultured Rat Hepatocytes. Toxicol Ind Health 32: 1074–1085.
  • Turkez H, Sonmez E, Di Stefano A, Mokhtar YI (2016b). Health Risk Assessments of Lithium Titanate Nanoparticles in Rat Liver Cell Model for Its Safe Applications in Nanopharmacology and Nanomedicine. Cytotechnology 68: 291–302.
  • Xia T, Kovochich M, Liong M, Mädler L, Gilbert B, Shi H, Yeh JI, Zink JI, Nel AE (2008). Comparison of the Mechanism of Toxicity of Zinc Oxide and Cerium Oxide Nanoparticles Based on Dissolution and Oxidative Stress Properties. ACS Nano 2: 2121–2134.
  • Zhao J, Castranova V (2011). Toxicology of Nanomaterials Used in Nanomedicine. J Toxicol Environ Heal - Part B Crit Rev 14: 593–632.
Toplam 29 adet kaynakça vardır.

Ayrıntılar

Konular Yapısal Biyoloji
Bölüm Articles
Yazarlar

Buğrahan Emsen 0000-0002-9636-2596

Hasan Türkez

Yayımlanma Tarihi 30 Kasım 2017
Kabul Tarihi 21 Ekim 2017
Yayımlandığı Sayı Yıl 2017 Cilt: 1 Sayı: 2

Kaynak Göster

APA Emsen, B., & Türkez, H. (2017). The protective role of resveratrol against zinc oxide induced nanotoxicity. Anatolian Journal of Botany, 1(2), 21-25. https://doi.org/10.30616/ajb.343665
AMA Emsen B, Türkez H. The protective role of resveratrol against zinc oxide induced nanotoxicity. Ant J Bot. Kasım 2017;1(2):21-25. doi:10.30616/ajb.343665
Chicago Emsen, Buğrahan, ve Hasan Türkez. “The Protective Role of Resveratrol Against Zinc Oxide Induced Nanotoxicity”. Anatolian Journal of Botany 1, sy. 2 (Kasım 2017): 21-25. https://doi.org/10.30616/ajb.343665.
EndNote Emsen B, Türkez H (01 Kasım 2017) The protective role of resveratrol against zinc oxide induced nanotoxicity. Anatolian Journal of Botany 1 2 21–25.
IEEE B. Emsen ve H. Türkez, “The protective role of resveratrol against zinc oxide induced nanotoxicity”, Ant J Bot, c. 1, sy. 2, ss. 21–25, 2017, doi: 10.30616/ajb.343665.
ISNAD Emsen, Buğrahan - Türkez, Hasan. “The Protective Role of Resveratrol Against Zinc Oxide Induced Nanotoxicity”. Anatolian Journal of Botany 1/2 (Kasım 2017), 21-25. https://doi.org/10.30616/ajb.343665.
JAMA Emsen B, Türkez H. The protective role of resveratrol against zinc oxide induced nanotoxicity. Ant J Bot. 2017;1:21–25.
MLA Emsen, Buğrahan ve Hasan Türkez. “The Protective Role of Resveratrol Against Zinc Oxide Induced Nanotoxicity”. Anatolian Journal of Botany, c. 1, sy. 2, 2017, ss. 21-25, doi:10.30616/ajb.343665.
Vancouver Emsen B, Türkez H. The protective role of resveratrol against zinc oxide induced nanotoxicity. Ant J Bot. 2017;1(2):21-5.

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