Çocukluk Çağında Akut Lenfoblastik Lösemi

Yıl 2018, Cilt: 27 Sayı: 4, 483 - 499, 31.12.2018

Ahmet Yöntem , İbrahim Bayram

https://doi.org/10.17827/aktd.397762

Cited By: 2

Öz

Çocukluk çağı kanserlerinin %25-30’unu lösemiler oluştururken, lösemilerin yaklaşık %97’sinden akut lösemiler sorumludur. On beş yaşından küçük çocuklarda akut lenfoblastik lösemi, akut myeloblastik lösemiye göre yaklaşık beş kat daha sık görülmektedir. Akut lenfoblastik lösemilerin Türkiye’de yıllık insidansı 1.5/100.000’dir. Akut lenfoblastik lösemide tedaviye yanıt ve sağ kalım oranları 1960’lı yıllarda %10 düzeyine ulaşmaz iken, bugün tedavi protokolleri ile hastaların yaklaşık olarak %80-90’ında remisyon sağlanabilmektedir. Yüksek riskli hastaların tedavisinde daha fazla ajan daha yüksek dozlarda ve daha uzun süre verilmektedir. Uygun vakalarda kök hücre nakli yapılmaktadır.

Anahtar Kelimeler

Lenfositik lösemi, Epidemiyoloji, Sınıflandırma, Prognoz

Acute Lymphoblastic Leukemia in Childhood

Öz

While leukemia is responsible for 25-30% of childhood cancers, acute leukemia accounts for about 97% of leukemia. In children younger than 15 years, Acute lymphoblastic leukemia is about five times more common than acute myeloid leukemia. The annual incidence of acute lymphoblastic leukemia in Turkey is 1.5/100,000. While treatment response and survival rates in acute lymphoblastic leukemia did not reach 10% in 1960s, approximately 80-90% of patients can be remitted with treatment protocols today. In the treatment of high-risk patients, more agents are given at higher doses and for longer periods. In appropriate cases, stem cells are transplanted.

Anahtar Kelimeler

Epidemiology, Classification, lymphoblastic leukemia

Kaynakça

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