Partial corpus callosum agenesis and colpocephaly: a case report*

Yıl 2016, Cilt: 10 Sayı: 3, 242 - 245, 30.12.2016

Ayşegül Güngör Aydın Esat Adıgüzel Aylin Aksoy Kemalettin Acar

Öz

Callosal abnormalities are mostly described as central nervous system malformations and can be symptomatic or asymptomatic. Herein, we report an autopsy case of a 50-year-old Syrian immigrant male with poor academic performance, presented with partial agenesis of the corpus callosum and colpocephaly. He was evidently asymptomatic until death.The cause of death was determined to be hypothermia. Autosy revealed a corpus callosum of 3 cm only in the anterior part. Posterior part of the corpus callosum, anterior, posterior and hippocampal commissures were absent. On coronal sections, inferior horn of the lateral ventricle was dilated. Histopathological examination showed petechial microhemorrhagic areas and congestion in the brain. This case report was presented to demonstrate a good example of corpus callosum agenesis in asymptomatic individuals except for poor academic performance. Furthermore, this is the first corpus callosum agenesis in medical literature encountered during medicolegal autopsy in an adult case.

Anahtar Kelimeler

autopsy, corpus callosum agenesis, malformation, poor academic performance, postmortem

Kaynakça

• 1. Aboitiz F, Montiel J. One hundred million years of interhemispheric communication: the history of the corpus callosum. Braz J Med Biol Res 2003;36:409–20.
• 2. Ramaekers G. Embryology and anatomy of the corpus callosum. In: Ramaekers G, Njiokiktjien C, editor. Pediatric behavioural neurology: the child’s corpus callosum. Vol 3. Amsterdam: Suyi Publications; 1991. p. 24–39.
• 3. Barkovich AJ, Norman D. Anomalies of the corpus callosum: Correlation with further anomalies of the brain. AJR Am J Roentgenol 1988;151:171–9.
• 4. Gianluigi P, McGahan JP, Nyberg DA. Cerebral malformations. In: Nyberg DA, McGahan JP, Pretorius DH, Pilu G, editors. Diagnostic imaging of fetal anomalies. Philadelphia (PA): Lippincott Williams and Wilkins; 2002. p. 221–91.
• 5. Derbali F, Ben FF, Rezgui A, Karmani M, Hajji R, Ben AO, Mzabi A, Laouani C. The corpus callosum agenesis: a case report. American Journal of Medical Case Reports2015;3:27–29.
• 6. Jeret JS, Serur D, Wisniewski K, Fisch C. Frequency of agenesis of the corpus callosum in the developmentally disabled population as determined by computerized tomography. Pediatr Neurosci 1985; 12:101–3.
• 7. Brescian NE, Curiel RE, Gass CS. Case study: a patient with agenesis of the corpus callosum with minimal associated neuropsychological impairment. Neurocase 2013;20:606–14.
• 8. Hetts SW, Sherr S, Chao S, Gobuty S, Barkovich AJ. Anomalies of the corpus callosum: An MR analysis of the phenotypic spectrum of associated malformations. AJR Am J Roentgenol 2006;187:1343–8.
• 9. Contro E, Nanni M, Bellussi F, Salsi G, Grisolia G, Sanz-Cortès M, Righini A, Rizzo N, Pilu G, Ghi T. The hippocampal commissure: a new finding at prenatal 3D ultrasound in fetuses with isolated complete agenesis of the corpus callosum. Prenat Diagn 2015;35:919– 22.
• 10. Tang PH, Bartha AI, Norton ME, Barkovich AJ, Sherr EH, Glenn OA. Agenesis of the corpus callosum: an MR imaging analysis of associated abnormalities in the fetus. AJNR Am J Neuroradiol 2009; 30:257-63.
• 11. Glass H, Shaw GM, Ma C, Sherr EH. Agenesis of the corpus callosum in California 1983-2003: a population-based study. Am J Med Genet A 2008;146A:2495–500.
• 12. Bodensteiner J, Schaefer GB, Breeding L, Cowan L. Hypoplasia of the corpus callosum: a study of 445 consecutive MRI scans. J Child Neurol 1994;9:47–9.
• 13. Kidron D, Shapira D, Ben SL, Malinger G, Lev D, Cioca A, Sharony R, Lerman ST. Agenesis of the corpus callosum. An autopsy study in fetuses. Virchows Arch 2016;468:219–30.
• 14. Santo S, D’Antonio F, Homfray T, Rich P, Pilu G, Bhide A, Thilaganathan B, PapageorghiouAT. Counseling in fetal medicine: agenesis of the corpus callosum. Ultrasound Obstet Gynecol 2012; 40:513–21.
• 15. Guillermo Davila-Gutierrez. Agenesis and dysgenesis of the corpus callosum. Semin Pediatr Neurol 2002;9:292–301.