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ÇEVRE DOSTU BİYOKATAİLİK MEMBRAN REAKTÖRDE ETİL LAKTAT SENTEZİ

Yıl 2016, Cilt: 17 Sayı: 2, 287 - 297, 14.07.2016
https://doi.org/10.18038/btda.96406

Öz

Bu çalışmada, laktik asit esteri olan etil laktatın, çevre dostu proses olarak nitelendiren, membran biyoreaktör ile üretimi 303, 313 ve 323 K  sıcaklıkta, 1:1, 3:1, 6:1 etanol:laktik asit molar reaktan besleme oranı ile gerçekleştirilmiştir. Sıcaklığın ve molar besleme oranının reaksiyon dönüşümüne ve ayırma performansına etkisi incelenmiştir. Membranların karakterizasyonunda taramalı elektron mikroskopu (SEM) ve atomik güç mikroskopu (AFM) kullanılmıştır. Sistem performansını belirlemek amacıyla, reaksiyonlar aynı koşulda kesikli reaktörlerde de yapılmıştır.  Eş molar beslemede, 323 K sıcaklıkta, kesikli reaktör ile 0.26 laktik asit dönüşümü elde edilirken, önerilen çevreci sistem ile 0.62 dönüşüm değeri elde edilmiştir. 

Kaynakça

  • Asthana NS, Kolah AK, Vu DT, Lira CT, Miller DJ, A Kinetic Model for the Esterification of Lactic Acid and Its Oligomers. Ind. Eng. Chem. Res. 2006: 45: 5251-5257.
  • Tanaka KR, Yoshikawa C, Ying HK, Okamoto KI. Application of zeolite T membrane to vapor- permeation-aided esterification of lactic acid with ethanol. Chem. Eng. Sci. 2002; 57: 1577-1584.
  • Reisch M. Solvent users look to replace NMP. Chemical and Engineering News, 2008; 86: 32.
  • Muse J, Colvin HA (2005). Use of ethyl lactate as an excipient for pharmaceutical compositions, US Patent No. 2005/0287179 A1.
  • Huang L, Zhu Y, Zheng H, Du M, Li Y. Vapor-phase hydrogenolysis of biomassderived lactate to 1,2-propanediol over supported metal catalysts. Appl. Catal., A:gen 2008; 349: 204-211.
  • Warner JC, Cannon AS, Dye KM. Environmental Impact Assessment Review. Green Chemistry 2004; 24: 775–799.
  • Gao J, Zhao XM, Zhou LY, Huang ZH. Investigation Of Ethyl Lactate Reactive Distillation Process. Trans IChemE, 2007; 85: 525–529.
  • Asthana N, Kolah A, Vu DT, Lira CT, Miller DJ. A Continuous Reactive Separation Process for Ethyl Lactate Formation. Organic Process Research & Development 2005; 9: 599-607.
  • Basile A, Luisa DP, Faisal H, Vincenzo P. Membrane Reactors for Energy Applications and Basic Chemical Production. Cambridge, United Kingdom: Woodhead Publishing, 2015.
  • Basile A. Handbook of membrane reactors, Volume 2: Reactor types and industrial applications. , Cambridge, United Kingdam: Woodhead Publishing Limited, 2013.
  • Julbe A, Ayral A. Catalytic Membrane Reactors Involving Inorganic Membranes, Water quality control and health 2007; 1: 30-43.
  • Gallucci F., Basile A, Hai F I. Introduction - A review of membrane reactors. In: Basile A, Gallucci F editors. Membranes for membrane reactors: preparation, optimization and selection United Kingdom: Wiley, 2011.
  • Gupta S, Bhattacharya A, Murthy CN. Tune to immobilize lipases on polymer membranes: Techniques, factors and prospects. Biocatalysis and Agricultural Biotechnology, 2013; 2: 171–190.
  • Hilal N, Nigmatullin R, Alpatova A. Immobilization of cross-linked lipase aggregates within microporous polymeric membranes. Journal of Membrane Science, 2004; 238: 131-141.
  • Wang Y, Xu J, Luo G, Dai Y. Immobilization of lipase by ultraŞltration and cross-linking onto the polysulfone membrane surface. Bioresource Technology 2008; 99: 2299–2303.
  • Wang Y, Hsieh YL. Immobilization of lipase enzyme in polyvinyl alcohol (PVA) nanofibrous membrane. Journal of Membrane Science 2008; 309: 73–81.
  • Dongzhi W, Chunang G, Qingxun S, Wu S. Enzymatic esterification for glycoside lactate synthesis in organic solvent Enzyme and Microbial Technology 2003; 33: 508–512.
  • Rachna D, Datta M. Esterification in organic solvents by lipase immobilized in polymer of PVA– alginate–boric acid. Process Biochemistry 2006; 41: 951–955.
  • Anna TH, Andrzej N An integrated process: Ester synthesis in an enzymatic membrane reactor and water sorption. Journal of Biotechnology 2007; 130: 47–56.
  • Rios GM, Belleville MP, Paolucci D, Sanchez J. Progress in enzymatic membrane reactors – a review. Journal of Membrane Science 2004; 242: 189–196.
  • Hilal N, Kochkodan V, Nigmatullin R, Goncharuk V, Laila AK. Lipase-immobilized biocatalytic membranes for enzymatic esterification: Comparison of various approaches to membrane preparation. Journal of Membrane Science, 2006; 268: 198–207.
  • Zvjezdana F, Gergely N, Durda VR, Katalin BB, Zsofia C, Laszlo G. Pervaporation-aided enzymatic esterifications in non-conventional media. Process Biochemistry 2012; 47: 1715–1722.
  • Nunes SP, Peinemann KV. Membrane Technology in the Chemical Industry. Germany: Wiley, 2006.
  • Delgado P, Sanz MT, Beltran S. Kinetic study for esterification of lactic acid with ethanol and hydrolysis of ethyl lactate using an ion-exchange resin catalyst. Chem. Eng. J. 2007; 126: 111–118.
  • Shuler ML, Kargi F. Bioprocess Engineering: Basic Concepts, 2nd edition, India: Prentice Hall, 1992.
  • Huang Z, Gao J, Zhao T, Li W, Zhou L, He Y. Lipase catalyzed synthesis of ethyl lactate. In: 3rd International Conference on Bioinformatics and Biomedical Engineering, 11-13 June 2009; Beijing, China. pp. 1-4.
  • Satoshi H, Masanori A, Koji T. Enzymatic esterification of lactic acid, utilizing the basicity of particular polar organic solvents to suppress the acidity of lactic acid. Journal of Chemical Technology and Biotechnology 2008; 83: 1503–1510.
  • Wijmans JG, Baker RW. The solution-diffusion model: a review. Journal of Membrane Science 1995; 107: 1-21.
  • Schaetzel P, Bouallouche R, Amar HA, Nguyen QT, Riffault BT, Marais S. Mass transfer in pervaporation: The key component approximation for the solution-diffusion model. Desalination 2010; 251: 161–166.
  • Schaetzel P, Vauclair C, Nguyen QT, Bouzerar R. A simplified solution–diffusion theory in pervaporation: the total solvent volume fraction model. Journal of Membrane Science 2004; 244: 117– 127.
Yıl 2016, Cilt: 17 Sayı: 2, 287 - 297, 14.07.2016
https://doi.org/10.18038/btda.96406

Öz

Kaynakça

  • Asthana NS, Kolah AK, Vu DT, Lira CT, Miller DJ, A Kinetic Model for the Esterification of Lactic Acid and Its Oligomers. Ind. Eng. Chem. Res. 2006: 45: 5251-5257.
  • Tanaka KR, Yoshikawa C, Ying HK, Okamoto KI. Application of zeolite T membrane to vapor- permeation-aided esterification of lactic acid with ethanol. Chem. Eng. Sci. 2002; 57: 1577-1584.
  • Reisch M. Solvent users look to replace NMP. Chemical and Engineering News, 2008; 86: 32.
  • Muse J, Colvin HA (2005). Use of ethyl lactate as an excipient for pharmaceutical compositions, US Patent No. 2005/0287179 A1.
  • Huang L, Zhu Y, Zheng H, Du M, Li Y. Vapor-phase hydrogenolysis of biomassderived lactate to 1,2-propanediol over supported metal catalysts. Appl. Catal., A:gen 2008; 349: 204-211.
  • Warner JC, Cannon AS, Dye KM. Environmental Impact Assessment Review. Green Chemistry 2004; 24: 775–799.
  • Gao J, Zhao XM, Zhou LY, Huang ZH. Investigation Of Ethyl Lactate Reactive Distillation Process. Trans IChemE, 2007; 85: 525–529.
  • Asthana N, Kolah A, Vu DT, Lira CT, Miller DJ. A Continuous Reactive Separation Process for Ethyl Lactate Formation. Organic Process Research & Development 2005; 9: 599-607.
  • Basile A, Luisa DP, Faisal H, Vincenzo P. Membrane Reactors for Energy Applications and Basic Chemical Production. Cambridge, United Kingdom: Woodhead Publishing, 2015.
  • Basile A. Handbook of membrane reactors, Volume 2: Reactor types and industrial applications. , Cambridge, United Kingdam: Woodhead Publishing Limited, 2013.
  • Julbe A, Ayral A. Catalytic Membrane Reactors Involving Inorganic Membranes, Water quality control and health 2007; 1: 30-43.
  • Gallucci F., Basile A, Hai F I. Introduction - A review of membrane reactors. In: Basile A, Gallucci F editors. Membranes for membrane reactors: preparation, optimization and selection United Kingdom: Wiley, 2011.
  • Gupta S, Bhattacharya A, Murthy CN. Tune to immobilize lipases on polymer membranes: Techniques, factors and prospects. Biocatalysis and Agricultural Biotechnology, 2013; 2: 171–190.
  • Hilal N, Nigmatullin R, Alpatova A. Immobilization of cross-linked lipase aggregates within microporous polymeric membranes. Journal of Membrane Science, 2004; 238: 131-141.
  • Wang Y, Xu J, Luo G, Dai Y. Immobilization of lipase by ultraŞltration and cross-linking onto the polysulfone membrane surface. Bioresource Technology 2008; 99: 2299–2303.
  • Wang Y, Hsieh YL. Immobilization of lipase enzyme in polyvinyl alcohol (PVA) nanofibrous membrane. Journal of Membrane Science 2008; 309: 73–81.
  • Dongzhi W, Chunang G, Qingxun S, Wu S. Enzymatic esterification for glycoside lactate synthesis in organic solvent Enzyme and Microbial Technology 2003; 33: 508–512.
  • Rachna D, Datta M. Esterification in organic solvents by lipase immobilized in polymer of PVA– alginate–boric acid. Process Biochemistry 2006; 41: 951–955.
  • Anna TH, Andrzej N An integrated process: Ester synthesis in an enzymatic membrane reactor and water sorption. Journal of Biotechnology 2007; 130: 47–56.
  • Rios GM, Belleville MP, Paolucci D, Sanchez J. Progress in enzymatic membrane reactors – a review. Journal of Membrane Science 2004; 242: 189–196.
  • Hilal N, Kochkodan V, Nigmatullin R, Goncharuk V, Laila AK. Lipase-immobilized biocatalytic membranes for enzymatic esterification: Comparison of various approaches to membrane preparation. Journal of Membrane Science, 2006; 268: 198–207.
  • Zvjezdana F, Gergely N, Durda VR, Katalin BB, Zsofia C, Laszlo G. Pervaporation-aided enzymatic esterifications in non-conventional media. Process Biochemistry 2012; 47: 1715–1722.
  • Nunes SP, Peinemann KV. Membrane Technology in the Chemical Industry. Germany: Wiley, 2006.
  • Delgado P, Sanz MT, Beltran S. Kinetic study for esterification of lactic acid with ethanol and hydrolysis of ethyl lactate using an ion-exchange resin catalyst. Chem. Eng. J. 2007; 126: 111–118.
  • Shuler ML, Kargi F. Bioprocess Engineering: Basic Concepts, 2nd edition, India: Prentice Hall, 1992.
  • Huang Z, Gao J, Zhao T, Li W, Zhou L, He Y. Lipase catalyzed synthesis of ethyl lactate. In: 3rd International Conference on Bioinformatics and Biomedical Engineering, 11-13 June 2009; Beijing, China. pp. 1-4.
  • Satoshi H, Masanori A, Koji T. Enzymatic esterification of lactic acid, utilizing the basicity of particular polar organic solvents to suppress the acidity of lactic acid. Journal of Chemical Technology and Biotechnology 2008; 83: 1503–1510.
  • Wijmans JG, Baker RW. The solution-diffusion model: a review. Journal of Membrane Science 1995; 107: 1-21.
  • Schaetzel P, Bouallouche R, Amar HA, Nguyen QT, Riffault BT, Marais S. Mass transfer in pervaporation: The key component approximation for the solution-diffusion model. Desalination 2010; 251: 161–166.
  • Schaetzel P, Vauclair C, Nguyen QT, Bouzerar R. A simplified solution–diffusion theory in pervaporation: the total solvent volume fraction model. Journal of Membrane Science 2004; 244: 117– 127.
Toplam 30 adet kaynakça vardır.

Ayrıntılar

Bölüm Araştırma Makalesi
Yazarlar

Filiz Uğur Nigiz

Nilüfer Durmaz Hilmioğlu Bu kişi benim

Yayımlanma Tarihi 14 Temmuz 2016
Yayımlandığı Sayı Yıl 2016 Cilt: 17 Sayı: 2

Kaynak Göster

APA Uğur Nigiz, F., & Durmaz Hilmioğlu, N. (2016). ÇEVRE DOSTU BİYOKATAİLİK MEMBRAN REAKTÖRDE ETİL LAKTAT SENTEZİ. Anadolu University Journal of Science and Technology A - Applied Sciences and Engineering, 17(2), 287-297. https://doi.org/10.18038/btda.96406
AMA Uğur Nigiz F, Durmaz Hilmioğlu N. ÇEVRE DOSTU BİYOKATAİLİK MEMBRAN REAKTÖRDE ETİL LAKTAT SENTEZİ. AUBTD-A. Ağustos 2016;17(2):287-297. doi:10.18038/btda.96406
Chicago Uğur Nigiz, Filiz, ve Nilüfer Durmaz Hilmioğlu. “ÇEVRE DOSTU BİYOKATAİLİK MEMBRAN REAKTÖRDE ETİL LAKTAT SENTEZİ”. Anadolu University Journal of Science and Technology A - Applied Sciences and Engineering 17, sy. 2 (Ağustos 2016): 287-97. https://doi.org/10.18038/btda.96406.
EndNote Uğur Nigiz F, Durmaz Hilmioğlu N (01 Ağustos 2016) ÇEVRE DOSTU BİYOKATAİLİK MEMBRAN REAKTÖRDE ETİL LAKTAT SENTEZİ. Anadolu University Journal of Science and Technology A - Applied Sciences and Engineering 17 2 287–297.
IEEE F. Uğur Nigiz ve N. Durmaz Hilmioğlu, “ÇEVRE DOSTU BİYOKATAİLİK MEMBRAN REAKTÖRDE ETİL LAKTAT SENTEZİ”, AUBTD-A, c. 17, sy. 2, ss. 287–297, 2016, doi: 10.18038/btda.96406.
ISNAD Uğur Nigiz, Filiz - Durmaz Hilmioğlu, Nilüfer. “ÇEVRE DOSTU BİYOKATAİLİK MEMBRAN REAKTÖRDE ETİL LAKTAT SENTEZİ”. Anadolu University Journal of Science and Technology A - Applied Sciences and Engineering 17/2 (Ağustos 2016), 287-297. https://doi.org/10.18038/btda.96406.
JAMA Uğur Nigiz F, Durmaz Hilmioğlu N. ÇEVRE DOSTU BİYOKATAİLİK MEMBRAN REAKTÖRDE ETİL LAKTAT SENTEZİ. AUBTD-A. 2016;17:287–297.
MLA Uğur Nigiz, Filiz ve Nilüfer Durmaz Hilmioğlu. “ÇEVRE DOSTU BİYOKATAİLİK MEMBRAN REAKTÖRDE ETİL LAKTAT SENTEZİ”. Anadolu University Journal of Science and Technology A - Applied Sciences and Engineering, c. 17, sy. 2, 2016, ss. 287-9, doi:10.18038/btda.96406.
Vancouver Uğur Nigiz F, Durmaz Hilmioğlu N. ÇEVRE DOSTU BİYOKATAİLİK MEMBRAN REAKTÖRDE ETİL LAKTAT SENTEZİ. AUBTD-A. 2016;17(2):287-9.