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BOTULİSMUSLU İNEKLERDE SERUM KOLİNESTERAZ VE AMİLOİD A SEVİYELERİNİN DEĞERLENDİRİLMESİ

Yıl 2017, Cilt: 6 Sayı: 2, 60 - 63, 31.08.2017

Öz




GİRİŞ ve AMAÇ: Bu çalışmada botulismuslu ve sağlıklı ineklerde serum kolinesteraz, amiloid A, albumin, total protein, total bilirubin, üre, GGT ve SDH araştırıldı.



YÖNTEM ve GEREÇLER: Çalışma ve kontrol grubunu gebe ve kuru dönemde iki ile beş yaşları arasında değişen 10 adet botulismuslu ve 6 adet sağlıklı holştayn inek oluşturdu. Parametrelerin serum düzeyleri Nefelometre BNII ve otoanalizör kullanılarak ölçüldü. Botilusmuslu hayvanların kan serumlarından ve silajdan fare inokulasyon testi yapıldı.



BULGULAR: Botulismuslu ineklerin kan serumlarında ve silajda Clostridium botulinum tip C ve tip D toksini tespit edildi. Serum, kolinesteraz, amiloid A, albumin, total protein, total bilirubin ve SDH botulismuslu ve sağlıklı ineklerde önemli bir değişiklik göstermezken botulismuslu ineklerde üre ve GGT düşük çıktı.



TARTIŞMA ve SONUÇ: Botulismuslu ineklerde kolinesteraz ve formlarının araştırılması botulismusun fizyopatolojisine ve prognozuna faydalı olabileceği sonucuna varıldı.


Kaynakça

  • 1. Braun U, Feige K, Schweizer G, Pospischil A. Clinical findings and treatment of 30 cattle with botulism. The Veterinary Record, 2005; 156, 438-441.
  • 2. Stöber M. In “Auswertung und Umsetzung der Untersuchungsbefunde”, Ed., GH Dirksen, D Gründer, M Stöber. Die klinische Untersuchung des Rindes, 3th ed. 1990; 647-662, Verlag Parey, Berlin.
  • 3. Burgen ASV, Dickens F, Zatman LJ. Action of botulinum toxin on the neuromusculer junction. J Physiol,1949; 109, 10-24.
  • 4. Aytekin İ, Kaya F, Atalay H. Evaluation of serum haptoglobin, ceruloplasmin and pseudocholinesterase levels in cows with Botulism. Kafkas Üniversitesi Veteriner Fakültesi Dergisi. 2016; 22, 367-371.
  • 5. Duru SY, Şahal M, Beşkaya A, Gazyağcı S. Investigation of Botulism Cases in a Cattle Herd in Bolu Province, Atatürk Üniversitesi Vet. Bil. Derg. 2016; 11,3, 332-338.
  • 6. Şenturk S, Cihan H. Outbreak of botulism in a dairy herd in Turkey. Irish Veterinary Journal. 2007; 60, 481-484.
  • 7. Çatık S, Akgül G, Mecitoğlu Z, Şentürk S. Bir Süt Sığır İşletmesinde Botulismus. Uludağ Üniversitesi Veteriner Fakültesi Dergisi. 2013; 32, 53-56.
  • 8. Ogunkeye O, Roluga AI. Serum cholinesterase activity helps to distinguish between liver and non liver disease aberration in liver function tests. Pathophysiology. 2006;13, 91-93.
  • 9. Omu AE, Al-Azemi MK, Omu FE, Fatinikun T, Abraham S, George S, Mahnazhath N. Butyrylcholinesterase activity in women with diabetes mellitus in pregnancy: Correlation with antioxidant activit. Journal of Obstetrics and Gynaecology. 2010; 30, 122–126.
  • 10. Stojević, Z, Piršljin J, Milinković-Tur S, Zdelar-Tuk M, Ljubić B. Clinically healthy dairy cows during lactation and in the dry period. Veterinarski Arhiv. 2005; 75, 67–73.
  • 11. Qarawi AA, Ali BH. Variation in the Normal Activity of Esterases in Plasma and Liver of Camels (Camelus dromedarius), Cattle (Bos indicus), Sheep (Ovis aries) and Goats (Capra hircus). Journal of Veterinary Medicine, 2003; A 50, 201-203.
  • 12. Kaplay SS. Acetylcholinesterase and butyrylcholinesterase of developing human brain. Biology of the Neonate. 1976; 28, 65–73.
  • 13. Aytekin İ, Onmaz AC, Ulucan A, Alp H. Effects of accidental ammonium sulphate poisoning on antioxidant / oxidant status in lambs. Revue De Medecıne Veterınaıre, 2011; 162, 7, 346-351.
  • 14. Öztürk AS, Aytekin İ, Özsoy ŞY, Öztürk OH, Altuğ N, Yılmaz N. Effects of caffeic acid phenethyl ester on oxidative stress, 15. hystopathology and some biochemical parameters in streptozotocin-induced diabetic rats. Turkish Journal of Biochemistry. 2015; 40,2, 149-156.
  • 16. Aytekin İ, Aksit A, Sait A, Kaya F, Aksit D, Gokmen M. Evaluation of oxidative stress via total antioxidant status, sialic acid, malondialdehyde and RT-PCR findings in sheep affected with bluetongue. Veterinary Record Open. 2015;2,1, e000054.
  • 17. Mamak N, Devrim AK, Aksit H, Aytekin İ, Yıldız R. Levels of antioxidant substances, acute phase response and lipid peroxidation in the left and right abomasum displacement in cows. Polish Journal of Veterinary Sciences, 2013; 16, 4, 731-733.
  • 18. Aytekin İ, Onmaz AC, Ulucan A, Alp H. Effects of accidental ammonium sulphate poisoning on antioxidant / oxidant status in lambs. Revue De Medecıne Veterınaıre, 2011; 162, 7, 346-351.
  • 19. Küçükkurt İ, Ciğerci IH, İnce S, Kozan E, Aytekin İ, Eryavuz A, Fidan AF. The Effects of Babesiosis on Oxidative Stress and DNA Damage in Anatolian Black Goats Naturally Infected with Babesia ovis. 2014; Iranian J Parasitol, 9, 1, 90-98.
  • 20. İnce S, Küçükkurt I, Aytekin I, Bacak E. Short-term effect of deltamethrin treatment on oxidative stres biomarkers in anatolian water buffaloes. Asian Journal of Animal and Veterinary Advances, 2010; 5, 4, 266-270.
  • 21. Gerlach T. Botulismus bei einer Golden-Retriever- Hündin. Tierärztliche Praxis, 2007; 35, 37-40.
  • 22. Van der Lugt JJ, De Wet SC, Bastianello SS, Kellerman TS, Van Jaarsveld LP. Two outbreaks of type C and type D botulism in sheep and goats in South Africa. The Journal of the South African Veterinary Association. 1995; 66, 77- 82.
  • 23. Fuentes VO, Fuentes PI. Butyrlcholinesterase Levels in Nubian and Saanen Goats in the Highlands of Mexico: Effect of Organophosphate Fenthion After Topical Application. Journal of Veterinary and Animal Advances. 2006;11, 278-881.
  • 24. Sun Y, Wang B, Shu S, Zhang H, Xu, C, Wu, L, Zia C. Critical thresolds of liver functions parameter for prediction in dairy cows using receiver operating characteristic (ROC) analysis. Veterinary Quarterly. 2015; 35, 3, 159-164.
  • 25. Sımonov M, Vlızlo V. Some Blood Markers Of The Functıonal State Of Lıver In Daıry Cows With Clınıcal Ketosıs. Bulgarian Journal of Veterinary Medicine. 2015; 18, 1, 74-82.

EVALUATION OF SERUM CHOLINESTERASE AND AMYLOID A LEVELS IN COWS WITH BOTULISM

Yıl 2017, Cilt: 6 Sayı: 2, 60 - 63, 31.08.2017

Öz




INTRODUCTION: The aim of this study was to determine serum cholinesterase, amyloid A, albumin, total protein, total bilirubin, urea, GGT and SDH in cows with or without botulism.



METHODS: The study included 10 holstein cows aged two to five years as the botulism group and control group consisting of 6 healthy cows. Serum concentration of all the parameters were measured using an autoanalyzer and Nefelometre equipment BNII. Mice inoculation test was performed in silage and blood that cows with botulism.



RESULTS: Clostridium botulinum type C and D toxins were determined in silage and blood that cows with botulism. Serum cholinesterase, amyloid A, albumin, total protein, total bilirubin and SDH did not differ significantly between two groups. Serum showed that in the botulism group urea and GGT were lower than in the control group.



DISCUSSION AND CONCLUSION: Serum cholinesterase and forms researched that may prove beneficial physiopathology and prognosis of botulism.


Kaynakça

  • 1. Braun U, Feige K, Schweizer G, Pospischil A. Clinical findings and treatment of 30 cattle with botulism. The Veterinary Record, 2005; 156, 438-441.
  • 2. Stöber M. In “Auswertung und Umsetzung der Untersuchungsbefunde”, Ed., GH Dirksen, D Gründer, M Stöber. Die klinische Untersuchung des Rindes, 3th ed. 1990; 647-662, Verlag Parey, Berlin.
  • 3. Burgen ASV, Dickens F, Zatman LJ. Action of botulinum toxin on the neuromusculer junction. J Physiol,1949; 109, 10-24.
  • 4. Aytekin İ, Kaya F, Atalay H. Evaluation of serum haptoglobin, ceruloplasmin and pseudocholinesterase levels in cows with Botulism. Kafkas Üniversitesi Veteriner Fakültesi Dergisi. 2016; 22, 367-371.
  • 5. Duru SY, Şahal M, Beşkaya A, Gazyağcı S. Investigation of Botulism Cases in a Cattle Herd in Bolu Province, Atatürk Üniversitesi Vet. Bil. Derg. 2016; 11,3, 332-338.
  • 6. Şenturk S, Cihan H. Outbreak of botulism in a dairy herd in Turkey. Irish Veterinary Journal. 2007; 60, 481-484.
  • 7. Çatık S, Akgül G, Mecitoğlu Z, Şentürk S. Bir Süt Sığır İşletmesinde Botulismus. Uludağ Üniversitesi Veteriner Fakültesi Dergisi. 2013; 32, 53-56.
  • 8. Ogunkeye O, Roluga AI. Serum cholinesterase activity helps to distinguish between liver and non liver disease aberration in liver function tests. Pathophysiology. 2006;13, 91-93.
  • 9. Omu AE, Al-Azemi MK, Omu FE, Fatinikun T, Abraham S, George S, Mahnazhath N. Butyrylcholinesterase activity in women with diabetes mellitus in pregnancy: Correlation with antioxidant activit. Journal of Obstetrics and Gynaecology. 2010; 30, 122–126.
  • 10. Stojević, Z, Piršljin J, Milinković-Tur S, Zdelar-Tuk M, Ljubić B. Clinically healthy dairy cows during lactation and in the dry period. Veterinarski Arhiv. 2005; 75, 67–73.
  • 11. Qarawi AA, Ali BH. Variation in the Normal Activity of Esterases in Plasma and Liver of Camels (Camelus dromedarius), Cattle (Bos indicus), Sheep (Ovis aries) and Goats (Capra hircus). Journal of Veterinary Medicine, 2003; A 50, 201-203.
  • 12. Kaplay SS. Acetylcholinesterase and butyrylcholinesterase of developing human brain. Biology of the Neonate. 1976; 28, 65–73.
  • 13. Aytekin İ, Onmaz AC, Ulucan A, Alp H. Effects of accidental ammonium sulphate poisoning on antioxidant / oxidant status in lambs. Revue De Medecıne Veterınaıre, 2011; 162, 7, 346-351.
  • 14. Öztürk AS, Aytekin İ, Özsoy ŞY, Öztürk OH, Altuğ N, Yılmaz N. Effects of caffeic acid phenethyl ester on oxidative stress, 15. hystopathology and some biochemical parameters in streptozotocin-induced diabetic rats. Turkish Journal of Biochemistry. 2015; 40,2, 149-156.
  • 16. Aytekin İ, Aksit A, Sait A, Kaya F, Aksit D, Gokmen M. Evaluation of oxidative stress via total antioxidant status, sialic acid, malondialdehyde and RT-PCR findings in sheep affected with bluetongue. Veterinary Record Open. 2015;2,1, e000054.
  • 17. Mamak N, Devrim AK, Aksit H, Aytekin İ, Yıldız R. Levels of antioxidant substances, acute phase response and lipid peroxidation in the left and right abomasum displacement in cows. Polish Journal of Veterinary Sciences, 2013; 16, 4, 731-733.
  • 18. Aytekin İ, Onmaz AC, Ulucan A, Alp H. Effects of accidental ammonium sulphate poisoning on antioxidant / oxidant status in lambs. Revue De Medecıne Veterınaıre, 2011; 162, 7, 346-351.
  • 19. Küçükkurt İ, Ciğerci IH, İnce S, Kozan E, Aytekin İ, Eryavuz A, Fidan AF. The Effects of Babesiosis on Oxidative Stress and DNA Damage in Anatolian Black Goats Naturally Infected with Babesia ovis. 2014; Iranian J Parasitol, 9, 1, 90-98.
  • 20. İnce S, Küçükkurt I, Aytekin I, Bacak E. Short-term effect of deltamethrin treatment on oxidative stres biomarkers in anatolian water buffaloes. Asian Journal of Animal and Veterinary Advances, 2010; 5, 4, 266-270.
  • 21. Gerlach T. Botulismus bei einer Golden-Retriever- Hündin. Tierärztliche Praxis, 2007; 35, 37-40.
  • 22. Van der Lugt JJ, De Wet SC, Bastianello SS, Kellerman TS, Van Jaarsveld LP. Two outbreaks of type C and type D botulism in sheep and goats in South Africa. The Journal of the South African Veterinary Association. 1995; 66, 77- 82.
  • 23. Fuentes VO, Fuentes PI. Butyrlcholinesterase Levels in Nubian and Saanen Goats in the Highlands of Mexico: Effect of Organophosphate Fenthion After Topical Application. Journal of Veterinary and Animal Advances. 2006;11, 278-881.
  • 24. Sun Y, Wang B, Shu S, Zhang H, Xu, C, Wu, L, Zia C. Critical thresolds of liver functions parameter for prediction in dairy cows using receiver operating characteristic (ROC) analysis. Veterinary Quarterly. 2015; 35, 3, 159-164.
  • 25. Sımonov M, Vlızlo V. Some Blood Markers Of The Functıonal State Of Lıver In Daıry Cows With Clınıcal Ketosıs. Bulgarian Journal of Veterinary Medicine. 2015; 18, 1, 74-82.
Toplam 24 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Makaleler
Yazarlar

İsmail Aytekin

Feyyaz Kaya Bu kişi benim

Yayımlanma Tarihi 31 Ağustos 2017
Gönderilme Tarihi 2 Mart 2017
Yayımlandığı Sayı Yıl 2017 Cilt: 6 Sayı: 2

Kaynak Göster

APA Aytekin, İ., & Kaya, F. (2017). BOTULİSMUSLU İNEKLERDE SERUM KOLİNESTERAZ VE AMİLOİD A SEVİYELERİNİN DEĞERLENDİRİLMESİ. Balıkesir Sağlık Bilimleri Dergisi, 6(2), 60-63.

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