Mentha longifolia (L.) Hudson subsp. Typhoides (Briq.) Harley var. Typhoides’in Hidroksil radikali ve Hipokloröz asiti Süpürme Aktivitesi

Yıl 2019, Cilt: 8 Sayı: 2, 406 - 412, 28.06.2019

Mahire Bayramoğlu Ferda Candan

https://doi.org/10.17798/bitlisfen.473761

Öz

Çalışmada Mentha
longifolia (L.) Hudson subsp.
Typhoides (Briq.) Harley var.
Typhoides’in Etanol
ekstraktının total antioksidan kapasitesi ile hidroksil radikal(OH^.)
ve hipokloröz asiti(HOCI) süpürme aktivitesinin değerlendirilmesi amaçlandı. M. longifolia
subsp. typhoides var. typhoides total antioksidan kapasitesi
569±8.57 mg AAE/gr  olarak belirlendi.
Bitki ekstraktının hidroksil radikali ve hipokloröz asit oluşumunu yüzde elli
inhibe eden derişimleri ise sırasıyla IC₅₀:71.85±1.79 ve IC₅₀:199.30±3.97
µg/mL olarak tesbit edildi. Sonuç olarak M. longifolia subsp. typhoides var. typhoides etanol ekstraktının total antioksidan
kapasitesi ve radikal süpürme aktivitesi değerlendirildiğinde bitkinin
potensiyel bir doğal antioksidan kaynağı olabileceği söylenebilir. Ayrıca, oksidatif
strese bağlı olarak ortaya çıkabilecek birçok hastalığın önlenmesi veya
tedavisinde terapötik ajanlar olarak oldukça yüksek etkiye sahip olabileceği
düşünülmektedir.

Anahtar Kelimeler

Hidroksil radikal, Hipokloröz asit

Kaynakça

• 1. Özgen U., Mavi A., Terzi Z., Yιldιrιm A., Coşkun M., Houghton P.J. 2006. Antioxidant properties of some medicinal Lamiaceae (Labiatae) species, Pharmaceutical biology, 44(2): 107-112.
• 2. Birben E., Sahiner U.M., Sackesen C., Erzurum S., Kalayci O. 2012. Oxidative stress and antioxidant defense, World Allergy Organization Journal, 5(1): 9.
• 3. Kasprzak K.S. 2002. Oxidative DNA and protein damage in metal-induced toxicity and carcinogenesis1, 3, Free Radical Biology and Medicine, 32(10): 958-967.
• 4. Iwasaki A., Gagnon C. 1992. Formation of reactive oxygen species in spermatozoa of infertile patients, Fertility and sterility, 57(2): 409-416.
• 5. Letelier M.E., Molina-Berríos A., Cortés-Troncoso J., Jara-Sandoval J., Holst M., Palma K., González-Lira V. 2008. DPPH and oxygen free radicals as pro-oxidant of biomolecules, Toxicology in vitro, 22(2): 279-286.
• 6. Alscher R.G., Donahue J.L., Cramer C.L. 1997. Reactive oxygen species and antioxidants: relationships in green cells, Physiologia Plantarum, 100(2): 224-233.
• 7. Sevindik M., Akgul H., Pehlivan M., Selamoglu Z. 2017. Determination of therapeutic potential of Mentha longifolia ssp. Longifolia, Fresen Environ Bull, 26, 4757-4763.
• 8. Mikaili P., Mojaverrostami S., Moloudizargari M., Aghajanshakeri S. 2013. Pharmacological and therapeutic effects of Mentha Longifolia L. and its main constituent, menthol, Ancient science of life, 33(2): 131.
• 9. Mimica-Dukic N., Popovic M., Jakovljevic V., Szabo A., Gašic O. 1999. Pharmacological studies of Mentha longifolia phenolic extracts. II. Hepatoprotective activity, Pharmaceutical biology, 37(3): 221-224.
• 10. Prieto P, Pineda M, Aguilar M. 1999. Spectrophotometric quantitation of antioxidant capacity through the formation of a phosphomolybdenum complex: specific application to the determination of vitamin E, Anal Biochem, 269: 337-341.
• 11. Kunchandy E., Rao M.N.A. 1990. Oxygen radical scavenging activity of curcumin,Int. J.Pharmacog, 58: 237-240.
• 12. Aruoma OI, Halliwell B. 1987. Action of hypochlorous acid on the antioxidant protective enzymes superoxide dismutase, catalase and glutathione peroxidase. Biochem J 248: 973– 97.
• 13. Pedraza‐Chaverrí J., Arriaga‐Noblecía G., Medina‐Campos O.N. 2007. Hypochlorous acid scavenging capacity of garlic. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 21(9); 884-888.
• 14. Gulluce M., Sahin F., Sokmen M., Ozer H., Daferera D., Sokmen A., Ozkan, H. Antimicrobial and antioxidant properties of the essential oils and methanol extract from Mentha longifolia L. ssp. longifolia. Food chemistry, 2007;103(4): 1449-1456.
• 15. Singh S., Das S.S., Singh G., Perotti M., Schuff C., Catalán C.A. 2015. In vitro antioxidant potentials and chemistry of essential oils and oleoresins from fresh and sun-dried Mentha longifolia L. Journal of Essential Oil Research, 27(1): 61-69.
• 16. Djeridane A., Yousfi M., Nadjemi B., Boutassouna D., Stocker P., Vidal N. 2006. Antioxidant activity of some Algerian medicinal plants extracts containing phenolic compounds. Food chemistry, 97(4): 654-660.
• 17. Abootalebian M., Keramat J., Kadivar M., Ahmadi F., Abdinian M. 2016. Comparison of total phenolic and antioxidant activity of different Mentha spicata and M. longifolia accessions, Annals of Agricultural Sciences, 61(2): 175-179.
• 18. Stanisavljević D.M., Stojičević S.S., Đorđević S.M., Zlatković B.P., Veličković D.T., Karabegović I.T., Lazić M.L. 2012. Antioxidant activity, the content of total phenols and flavonoids in the ethanol extracts of Mentha longifolia (L.) Hudson dried by the use of different techniques, Chemical Industry and Chemical Engineering Quarterly, 18(3): 411-420.
• 19. Hajlaoui H., Trabelsi N., Noumi E., Snoussi M., Fallah H., Ksouri R., Bakhrouf A. 2009. Biological activities of the essential oils and methanol extract of tow cultivated mint species (Mentha longifolia and Mentha pulegium) used in the Tunisian folkloric medicine. World Journal of Microbiology and Biotechnology, 25(12): 2227-2238.
• 20. Fatiha B., Didier H., Naima G., Khodir M., Martin K., Léocadie K., Pierre D. 2015. Phenolic composition, in vitro antioxidant effects and tyrosinase inhibitory activity of three Algerian Mentha species: M. spicata (L.), M. pulegium (L.) and M. rotundifolia (L.) Huds (Lamiaceae), Industrial crops and products, 74, 722-730.
• 21. Orhan F., Barış Ö., Yanmış D., Bal T., Güvenalp Z., Güllüce M. 2012. Isolation of some luteolin derivatives from Mentha longifolia (L.) Hudson subsp. longifolia and determination of their genotoxic potencies. Food chemistry, 135(2): 764-769.
• 22. Bahadori M.B., Zengin G., Bahadori S., Dinparast L., Movahhedin N. 2018. Phenolic composition and functional properties of wild mint (Mentha longifolia var. calliantha (Stapf) Briq.), International Journal of Food Properties, 21(1): 183-193
• 23. Battino M., Bullon P., Wilson M., Newman H. 1999. Oxidative injury and inflammatory periodontal diseases: the challenge of anti-oxidants to free radicals and reactive oxygen species, Critical Reviews in Oral Biology & Medicine, 10(4): 458-476.
• 24. Valko M., Rhodes C., Moncol J., Izakovic M.M., Mazur M. 2006. Free radicals, metals and antioxidants in oxidative stress-induced cancer, Chemico-biological interactions, 160(1): 1-40.
• 25. Pullar J.M., Vissers M.C., Winterbourn C.C. 2000. Living with a killer: the effects of hypochlorous acid on mammalian cells, IUBMB life, 50(4‐5): 259-266.
• 26. Mika D., Guruvayoorappan C. 2011. Myeloperoxidase: the yin and yang in tumour progression, Journal of experimental therapeutics & oncology, 9(2):93-100.
• 27. Panasenko O.M., Gorudko I.V., Sokolov A.V. 2013. Hypochlorous acid as a precursor of free radicals in living systems, Biochemistry (Moscow), 78(13): 1466-1489
• 28. Senkardes I., Tuzlaci E. 2014. Some Ethnobotanical Notes from Gundogmus District (Antalya/Turkey). Clinical and Experimental Health Sciences, 4(2): 63.
• 29. Arasan S., Kaya I. 2015. Some important plants belonging to asteraceae family used in folkloric medicine in Savur (Mardin/Turkey) area and their application areas. J Food Nutr Res, 3:337-340.
• 30. Dekigai H., Murakami M., Kita T. 1995. Mechanism ofhelicobacter pylori-associated gastric mucosal injury. Digestive diseases and sciences, 40(6); 1332-1339.
• 31. Lapenna D., Cuccurullo F. 1996. Hypochlorous acid and its pharmacological antagonism: an update Picture, General pharmacology, 27(7):1145-1147.