Bruton hastalığı zemininde gelişen PML olgusuna pediatrik radyoloji açısından bakış

Yıl 2017, Cilt: 1 Sayı: 3, 88 - 93, 18.12.2017

Mehmet Burak Ozkan Meltem Ceyhan Bilgici Alişan Yildiran

Öz

Jc papovavirüs nörontropik virüs olup oligodendrositlerde
demyelinizasyona neden olmaktadır. Difüzyon tensör incelemede beyaz cevher
yolaklarında sağ frontal bölgede kesinti izlenmektedir. Multivoksel
spektroskopi incelemede Cho/Cr ve mI/Cr oranlarında artış izlenirken NAA miktarlarında
düşme izlenmektedir.

Bu bulgular demyelinizan hasarı gösterir-ken, mI
hastalığın şiddetini göstermektedir. Bizim bu çalışmada amacımız ileri MRG
tekniklerini kullanarak immün yetmezlik olan bir olguda gelişen PML
hastalığının bulgularını tartışmaktır. 

Anahtar Kelimeler

pediatrik radyoloji, DTİ, MRİ, PML

The role of advanced magnetic resonance imaging techniques in a pediatric Progressive Multifocal Leukoencephalopathy patient associated with Bruton disease : The pediatric radiologist ‘s approach within a case report

Öz

JC
papovavirus, which is a neurotropic virus, causes a demyelinating process in
oligodendrocytes. Diffusion tensor imaging (DTI) showed white-matter tract
interruptions in the right frontal hemispheric region. Multivoxel spectroscopy
revealed an increase in the Cho/Cr and mI/Cr ratios, and a decreased in the
N-acetylaspartate (NAA) values. These values show the demyelinating process and
damage, whereas mI levels are known to be the predictor of the severity of the
dis-ease. In this case report, our goal is to discuss the supportive findings
and benefits of using advanced MR techniques in an immunocompromised pediatric
patient suffering from PML disease. 

Anahtar Kelimeler

pediatric radiology, PML, JC virus, DTI imaging

Kaynakça

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