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EVALUATION OF RELATIONSHIP BETWEEN PAIN SCORE AND SERUM VITAMIN B12 AND FOLATE LEVELS IN FIBROMYALGIA PATIENTS

Yıl 2018, Cilt: 2 Sayı: 1, 51 - 59, 11.02.2018

Öz

Aim: Fibromyalgia syndrome
(FMS) is a common rheumatologic disorder which is characterized by chronic
widespread musculoskeletal pain and several additional symptoms including
morning stiffness, fatigue, sleep disorder, low pain threshold, cognitive dysfunction,
anxiety and depressive episodes. Folate and vitamin B12 are two metabolically
and clinically related vitamins that share some important functions related to
the one-carbon metabolism and related diseases. Studies have revealed that
vitamin B12 and folate are associated with pain and pain-related disorders. The
aim of this study was to compare serum vitamin B12 and folate levels between
FMS patient group and the control group and to present a new evidence of
pathogenesis FMS disease.

Material and Methods: 46 female FMS outpatients and 46 healthy
individuals were enrolled in the study. Clinical information and biochemical
markers including vitamin B12, folate, erythrocyte sedimentation rate (ESR) and
C-reactive protein (CRP) and visual analogue scale (VAS) scores were obtained
from the patients’ medical files.

Results: There were no significant differences in vitamin B12, folate
and ESR levels between the two groups (p >0.05). Serum CRP levels was
significantly increased in FMS group (p =0.027). There was no correlation
between VAS scores and biochemical markers in patients group.







Conclusions: The results of this study have indicated that vitamin B12
and folate levels are not involved in the pathogenesis of FMS. No relevant
correlations between the perception of pain and one carbon metabolism
biomarkers were observed in FMS patients.

Kaynakça

  • References: 1. Makrani AH, Afshari M, Ghajar M, et al. Vitamin D and fibromyalgia: a meta-analysis. Korean J Pain. 2017 Oct;30(4):250-257.2. Cohen H. Controversies and challenges in fibromyalgia: a review and a proposal. Ther Adv Musculoskelet Dis. 2017 May;9(5):115-127. 3. Queiroz LP. Worldwide epidemiology of fibromyalgia. Curr Pain Headache Rep. 2013 Aug;17(8):356. 4. Guéant JL, Caillerez-Fofou M, Battaglia-Hsu S, et al. Molecular and cellular effects of vitamin B12 in brain, myocardium and liver through its role as co-factor of methionine synthase. Biochimie. 2013 May;95(5):1033-405. Selhub J. Folate, vitamin B12 and vitamin B6 and one carbon metabolism. J Nutr Health Aging. 2002;6(1):39-42. Review.6. Negrão L, Almeida P, Alcino S, et al. Effect of the combination of uridine nucleotides, folic acid and vitamin B12 on the clinical expression of peripheral neuropathies. Pain Manag. 2014 May;4(3):191-6.7. Zhang M, Han W, Hu S, et al. Methylcobalamin: a potential vitamin of pain killer. Neural Plast. 2013;2013:424651. 8. Wolfe F, Smythe HA, Yunus MB, et al. The American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia. Report of the Multicenter Criteria Committee. Arthritis Rheum. 1990 Feb;33(2):160-72.9. Jang HB, Han YH, Piyathilake CJ, et al. Intake and blood concentrations of folate and their association with health-related behaviors in Korean college students. Nutr Res Pract. 2013 Jun;7(3):216-23. 10. Moukaddem A, Chaaya M, Slim ZFN, et al. Fibromyalgia: epidemiology and risk factors, a population-based case-control study in Lebanon. Int J Rheum Dis. 2017 Feb;20(2):169-176. 11. Ducker GS, Rabinowitz JD. One-Carbon Metabolism in Health and Disease. Cell Metab. 2017 Jan 10;25(1):27-42. 12. Coşar A, Ipçioğlu OM, Ozcan O et al. Folate and homocysteine metabolisms and their roles in the biochemical basis of neuropsychiatry. Turk J Med Sci. 2014;44(1):1-9. Review.13. Bengtsson A, Henriksson KG, Jorfeldt L, et al. Primary fibromyalgia. A clinical and laboratory study of 55 patients. Scand J Rheumatol. 1986;15(3):340-7.14. Ortancil O, Sanli A, Eryuksel R, et al. Association between serum ferritin level and fibromyalgia syndrome. Eur J Clin Nutr. 2010 Mar;64(3):308-12. 15. Regland B, Andersson M, Abrahamsson L, et al. Increased concentrations of homocysteine in the cerebrospinal fluid in patients with fibromyalgiaand chronic fatigue syndrome. Scand J Rheumatol. 1997;26(4):301-7.16. de Carvalho JF, Silva DN. Serum levels of vitamin B12 (cobalamin) in fibromyalgia. Rheumatol Int. 2016 May;36(5):741-2. 17. Ponce-Monter HA, Ortiz MI, Garza-Hernández AF, et al. Effect of diclofenac with B vitamins on the treatment of acute pain originated by lower-limb fracture and surgery. Pain Res Treat. 2012;2012:104782.18. Blencowe H, Cousens S, Modell B et al. Folic acid to reduce neonatal mortality from neural tube disorders. Int J Epidemiol. 2010 Apr;39 Suppl 1:i110-21. 19. Bender A, Hagan KE, Kingston N. The association of folate and depression: A meta-analysis. J Psychiatr Res. 2017 Dec;95:9-18. 20. Pepys MB, Hirschfield GM. C-reactive protein: a critical update. J Clin Invest. 2003;111(12):1805–12. 21. Xiao Y, Haynes WL, Michalek JE et al. Elevated serum high-sensitivity C-reactive protein levels in fibromyalgia syndrome patients correlate with body mass index, interleukin-6, interleukin-8, erythrocyte sedimentation rate. Rheumatol Int. 2013 May;33(5):1259-64. 22. Lund Håheim L, Nafstad P, Olsen I et al. C-reactive protein variations for different chronic somatic disorders. Scand J Public Health. 2009 Aug;37(6):640-6. 23. Rus A, Molina F, Gassó M, et al. Nitric Oxide, Inflammation, Lipid Profile, and Cortisol in Normal- and Overweight Women With Fibromyalgia. Biol Res Nurs. 2016 Mar;18(2):138-46. 24. Li Z, Gueant-Rodriguez RM, Quilliot D et al. Folate and vitamin B12 status is associated with insulin resistance and metabolic syndrome in morbid obesity. Clin Nutr. 2017 Jul 24. pii: S0261-5614(17)30247-9.25. Okifuji A, Bradshaw DH, Olson C. Evaluating obesity in fibromyalgia: neuroendocrine biomarkers, symptoms, and functions. Clin Rheumatol. 2009 Apr;28(4):475-8.

FİBROMİYALJİ HASTALARINDA VİTAMİN B12 VE FOLAT DÜZEYLERİ İLE AĞRI SKORLARI ARASINDAKİ İLİŞKİNİN İNCELENMESİ

Yıl 2018, Cilt: 2 Sayı: 1, 51 - 59, 11.02.2018

Öz

Amaç: Fibromiyalji sendromu (FMS),
yaygın kas iskelet sistemi ağrısı ile sabah sertliği, yorgunluk, uyku
bozukluğu, düşük ağrı eşiği, bilişsel işlev bozukluğu, anksiyete ve depresif
ataklar gibi ilave semptomlar ile karakterize, yaygın bir romatolojik
bozukluktur. Folat ve B12 vitamini, tek karbon metabolizması ve ilişkili
hastalıklarla ilgili önemli işlevleri paylaşan metabolik ve klinik olarak
birbirleri ile ilişkili vitaminlerdir. Yapılan çalışmalarda, folat ve B12
vitamininin ağrı ve ağrıya bağlı rahatsızlıklarla ilişkili olduğu
gösterilmiştir. Bu çalışmada, FMS hasta grubu ile kontrol grubu arasındaki
serum vitamin B12 ve folat düzeylerini karşılaştırmak ve FMS hastalık
patogenezine yeni kanıtlar sunmayı amaçlamaktayız.

Gereç ve Yöntem: Çalışmaya 46
kadın FMS hastası ve 46 sağlıklı birey alındı. Hastaların dosyalarından B12
vitamini, folat, eritrosit sedimantasyon hızı (ESR) ve C-reaktif protein (CRP)
ve görsel analog skalası (VAS) skorları dahil olmak üzere klinik bilgi ve
biyokimyasal belirteçler elde edildi.

Bulgular: İki grup arasında
vitamin B12, folat ve ESR düzeylerinde anlamlı farklılık olmadığı bulundu (p>
0.05). Serum CRP düzeyleri, FMS grubunda anlamlı olarak arttığı gözlendi (p =
0.027). Hasta grubunda, VAS skorları ile biyokimyasal belirteçler arasında
korelasyon olmadığı gözlendi.







Sonuç: Bu çalışma, B12
vitamini ve folat düzeylerinin FMS patogenezinde yer almadığını göstermiştir.
FMS hastalarında ağrı algılaması ile tek karbon metabolizma belirteçleri
arasında korelasyon gözlenmemiştir.

Kaynakça

  • References: 1. Makrani AH, Afshari M, Ghajar M, et al. Vitamin D and fibromyalgia: a meta-analysis. Korean J Pain. 2017 Oct;30(4):250-257.2. Cohen H. Controversies and challenges in fibromyalgia: a review and a proposal. Ther Adv Musculoskelet Dis. 2017 May;9(5):115-127. 3. Queiroz LP. Worldwide epidemiology of fibromyalgia. Curr Pain Headache Rep. 2013 Aug;17(8):356. 4. Guéant JL, Caillerez-Fofou M, Battaglia-Hsu S, et al. Molecular and cellular effects of vitamin B12 in brain, myocardium and liver through its role as co-factor of methionine synthase. Biochimie. 2013 May;95(5):1033-405. Selhub J. Folate, vitamin B12 and vitamin B6 and one carbon metabolism. J Nutr Health Aging. 2002;6(1):39-42. Review.6. Negrão L, Almeida P, Alcino S, et al. Effect of the combination of uridine nucleotides, folic acid and vitamin B12 on the clinical expression of peripheral neuropathies. Pain Manag. 2014 May;4(3):191-6.7. Zhang M, Han W, Hu S, et al. Methylcobalamin: a potential vitamin of pain killer. Neural Plast. 2013;2013:424651. 8. Wolfe F, Smythe HA, Yunus MB, et al. The American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia. Report of the Multicenter Criteria Committee. Arthritis Rheum. 1990 Feb;33(2):160-72.9. Jang HB, Han YH, Piyathilake CJ, et al. Intake and blood concentrations of folate and their association with health-related behaviors in Korean college students. Nutr Res Pract. 2013 Jun;7(3):216-23. 10. Moukaddem A, Chaaya M, Slim ZFN, et al. Fibromyalgia: epidemiology and risk factors, a population-based case-control study in Lebanon. Int J Rheum Dis. 2017 Feb;20(2):169-176. 11. Ducker GS, Rabinowitz JD. One-Carbon Metabolism in Health and Disease. Cell Metab. 2017 Jan 10;25(1):27-42. 12. Coşar A, Ipçioğlu OM, Ozcan O et al. Folate and homocysteine metabolisms and their roles in the biochemical basis of neuropsychiatry. Turk J Med Sci. 2014;44(1):1-9. Review.13. Bengtsson A, Henriksson KG, Jorfeldt L, et al. Primary fibromyalgia. A clinical and laboratory study of 55 patients. Scand J Rheumatol. 1986;15(3):340-7.14. Ortancil O, Sanli A, Eryuksel R, et al. Association between serum ferritin level and fibromyalgia syndrome. Eur J Clin Nutr. 2010 Mar;64(3):308-12. 15. Regland B, Andersson M, Abrahamsson L, et al. Increased concentrations of homocysteine in the cerebrospinal fluid in patients with fibromyalgiaand chronic fatigue syndrome. Scand J Rheumatol. 1997;26(4):301-7.16. de Carvalho JF, Silva DN. Serum levels of vitamin B12 (cobalamin) in fibromyalgia. Rheumatol Int. 2016 May;36(5):741-2. 17. Ponce-Monter HA, Ortiz MI, Garza-Hernández AF, et al. Effect of diclofenac with B vitamins on the treatment of acute pain originated by lower-limb fracture and surgery. Pain Res Treat. 2012;2012:104782.18. Blencowe H, Cousens S, Modell B et al. Folic acid to reduce neonatal mortality from neural tube disorders. Int J Epidemiol. 2010 Apr;39 Suppl 1:i110-21. 19. Bender A, Hagan KE, Kingston N. The association of folate and depression: A meta-analysis. J Psychiatr Res. 2017 Dec;95:9-18. 20. Pepys MB, Hirschfield GM. C-reactive protein: a critical update. J Clin Invest. 2003;111(12):1805–12. 21. Xiao Y, Haynes WL, Michalek JE et al. Elevated serum high-sensitivity C-reactive protein levels in fibromyalgia syndrome patients correlate with body mass index, interleukin-6, interleukin-8, erythrocyte sedimentation rate. Rheumatol Int. 2013 May;33(5):1259-64. 22. Lund Håheim L, Nafstad P, Olsen I et al. C-reactive protein variations for different chronic somatic disorders. Scand J Public Health. 2009 Aug;37(6):640-6. 23. Rus A, Molina F, Gassó M, et al. Nitric Oxide, Inflammation, Lipid Profile, and Cortisol in Normal- and Overweight Women With Fibromyalgia. Biol Res Nurs. 2016 Mar;18(2):138-46. 24. Li Z, Gueant-Rodriguez RM, Quilliot D et al. Folate and vitamin B12 status is associated with insulin resistance and metabolic syndrome in morbid obesity. Clin Nutr. 2017 Jul 24. pii: S0261-5614(17)30247-9.25. Okifuji A, Bradshaw DH, Olson C. Evaluating obesity in fibromyalgia: neuroendocrine biomarkers, symptoms, and functions. Clin Rheumatol. 2009 Apr;28(4):475-8.
Toplam 1 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Klinik Tıp Bilimleri
Bölüm ARAŞTIRMA MAKALESİ
Yazarlar

Serdar Hıra

Hatice Gülşah Karataş Bu kişi benim

İsmail Haskul Bu kişi benim

Ramazan Gündüz Bu kişi benim

Betül Üstün Bu kişi benim

Müfit Akyüz Bu kişi benim

Yayımlanma Tarihi 11 Şubat 2018
Yayımlandığı Sayı Yıl 2018 Cilt: 2 Sayı: 1

Kaynak Göster

APA Hıra, S., Karataş, H. G., Haskul, İ., Gündüz, R., vd. (2018). EVALUATION OF RELATIONSHIP BETWEEN PAIN SCORE AND SERUM VITAMIN B12 AND FOLATE LEVELS IN FIBROMYALGIA PATIENTS. Balıkesir Medical Journal, 2(1), 51-59.