Bazı Yeni Tiyofen-2,5 Dikarboksilik Asit bis-aril (alkil) amid Bileşiklerinin Antitümör ve Antibakteriyel Özelliklerinin İncelenmesi

Yıl 2018, Cilt: 39 Sayı: 2, 357 - 365, 29.06.2018

Pelin Koparır Akif Evren Parlak

https://doi.org/10.17776/csj.412145

Cited By: 1

Öz

Tiyofen türevli bileşikler, çeşitli farmakolojik aktiviteleri
nedeniyle kimya, biyoloji ve farmakolojide ilgi uyandırır. Bu çalışma,
tiyofen-2,5-dikarboksilik asit bis-aril (alkil) amid bileşiklerinin antitümör
ve antibakteriyel aktivitesini araştırmayı amaçlamaktadır. Bu çalışmada, tüm
bileşikler için antibakteriyel ve antitümör özellikleri in vitro ortamda belirlenmiştir.

Sonuç olarak, hücre canlılığı deneyleri, bu bileşiklerin
bazılarının in vitro anti-tümör aktivitesine sahip olduğunu göstermektedir.
Ayrıca, bazı bileşiklerin etkili bir antibakteriyel aktiviteye sahip olduğu da
bulunmuştur.

Anahtar Kelimeler

1-3-4 tiadiazol, antioksidan aktivite, radikal süpürücü aktivite, biyolojik aktiviteler

Investigation of Antitumor and Antibacterial Properties of Some New Thiophene-2,5-Dicarboxylic Acid bis-aryl (alkyl) amide Compounds

Öz

Thiophene-derived compounds are of
interest in chemistry, biology and pharmacology because of their various
pharmacological activities This study aims to investigate the antitumor and
antibacterial activity of
thiophene-2,5-dicarboxylic acid bis-aryl (alkyl) amide compounds. In this study, the properties of
antibacterial and antitumor were determined in
vitro media, for all compounds.

As a result, cell viability
experiments show that some of this compounds have effective in vitro antitumor activity. In
addition, it has also been found that some compounds have an effective
antibacterial activity

Anahtar Kelimeler

Thiophene-derived compounds, antibacterial activity, antimicrobial activities, antitumor activity, cancer

Kaynakça

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