A CASE OF BULLOUS ACRAL ERYTHEMA DUE TO BLEOMYCIN

Yıl 2017, Cilt: 1 Sayı: 1, 32 - 35, 28.12.2017

Aslı Tatlıparmak Berna Aksoy Erol Koç

Öz

Acral erythema
is a cutaneous reaction that is frequently caused by chemotherapy agents.
Bullous acral erythema is a rare variation of this condition and the reported
cases in the literature are related mostly to cytarabine and methotrexate. A
50-year-old male patient presented to our dermatology outpatient clinic with
painful lesions of the hands and feet that is present for five days. In his
medical history, there was an operation with the diagnosis of right testicular
seminoma two years ago and history of taking bleomycin chemotherapy due to a
recurrence two months ago. There were painful erythematous plaques and bullae
on palmoplantar areas in dermatologic examination. When bullae were drained
with a sterile injector, the content is detected to be serous-hemorrhagic
fluid. With the current anamnesis and clinical findings the patient was
diagnosed to have bullous acral erythema and topical Triticum vulgare extract
therapy was started. Acral erythema is a common dermatosis secondary to
chemotherapeutic agents and bullous acral erythema is a rare variant. Bullous
acral erythema related to bleomycin is rarely reported in the literature, while
methotrexate and cytarabine are the frequently accused agents.

Anahtar Kelimeler

Acral, bleomycin, bullous, chemotherpy, erythema

Kaynakça

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• 3. Ozmen S, Dogru M, Bozkurt C, Kocaoglu AC. Probable cytarabine induced acral erythema:report of 2 pediatric cases. J Pediatr Hematol Oncol. 2013;35:11-13.
• 4. Richards KN, Ivan D, Rashid RM, Chon SY. Paclitaxel induced acral erythema. Arch Dermatol. 2012;148:1333-1334.
• 5. Azurdia RM, Clark RE, Friedmann PS. Chemotherapy induced acral erythema with bullous reaction. Clin Exp Dermatol. 1999;24:64-66.
• 6. Tezer H, Kuskonmaz B, Kara A et al. Intravenous immunglubulin in the treatment of severe methotrexate induced acral erythema. J Pediatr Hematol Oncol. 2008;30:391-393.