Research Article
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Year 2024, Volume: 3 Issue: 1, 306 - 311, 29.03.2024

Abstract

References

  • 1. Matthews A, Dowswell T, Haas DM, Doyle M, O’Mathúna DP. Interventions for nausea and vomiting in early pregnancy. Cochrane Database Syst Rev. 2010;(9):CD007575. doi:10.1002/14651858.CD007575.pub2
  • 2. London V, Grube S, Sherer DM, Abulafia O. Hyperemesis Gravidarum: A Review of Recent Literature. Pharmacology. 2017;100(3-4):161-171. doi:10.1159/000477853
  • 3. Pham A, Okpara R, Rollins N, Jacob R. Intrauterine Fetal Demise: A Rare Complication of Wernicke’s Encephalopathy Secondary to Hyperemesis Gravidarum. Cureus. 2023;15(10):e47270. doi:10.7759/cureus.47270
  • 4. Heitmann K, Nordeng H, Havnen GC, Solheimsnes A, Holst L. The burden of nausea and vomiting during pregnancy: severe impacts on quality of life, daily life functioning and willingness to become pregnant again – results from a cross-sectional study. BMC Pregnancy Childbirth. 2017;17(1):75. doi:10.1186/s12884-017-1249-0
  • 5. Dodds L, Fell DB, Joseph KS, Allen VM, Butler B. Outcomes of pregnancies complicated by hyperemesis gravidarum. Obstet Gynecol. 2006;107(2 Pt 1):285-292. doi:10.1097/01.AOG.0000195060.22832.cd
  • 6. Jansen LAW, Nijsten K, Limpens J, et al. Perinatal outcomes of infants born to mothers with hyperemesis gravidarum: A systematic review and meta-analysis. Eur J Obstet Gynecol Reprod Biol. 2023;284:30-51. doi:10.1016/j.ejogrb.2023.03.004
  • 7. Lee NM, Saha S. Nausea and vomiting of pregnancy. Gastroenterol Clin North Am. 2011;40(2):309-334, vii. doi:10.1016/j.gtc.2011.03.009
  • 8. Briggs DI, Andrews ZB. Metabolic status regulates ghrelin function on energy homeostasis. Neuroendocrinology. 2011;93(1):48-57. doi:10.1159/000322589
  • 9. Zhang JV, Ren PG, Avsian-Kretchmer O, et al. Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin’seffects on food intake. Science. 2005;310(5750):996-999. doi:10.1126/science.1117255
  • 10. Caro JF, Sinha MK, Kolaczynski JW, Zhang PL, Considine RV. Leptin: the tale of an obesity gene. Diabetes. 1996;45(11):1455-1462. doi:10.2337/diab.45.11.1455
  • 11. Mantzoros CS, Dunaif A, Flier JS. Leptin concentrations in the polycystic ovary syndrome. J Clin Endocrinol Metab. 1997;82(6):1687-1691. doi:10.1210/jcem.82.6.4017
  • 12. Peeters TL, Muls E, Janssens J, et al. Effect of motilin on gastric emptying in patients with diabetic gastroparesis. Gastroenterology. 1992;102(1):97-101. doi:10.1016/0016-5085(92)91788-6
  • 13. Luiking YC, Peeters TL, Stolk MF, et al. Motilin induces gall bladder emptying and antral contractions in the fasted state in humans. Gut. 1998;42(6):830-835. doi:10.1136/gut.42.6.830
  • 14. Cave DR. Transmission and epidemiology of Helicobacter pylori. Am J Med. 1996;100(5A):12S-17S; discussion 17S-18S. doi:10.1016/s0002-9343(96)80224-5
  • 15. Chey WD, Wong BCY, Practice Parameters Committee of the American College of Gastroenterology. American College of Gastroenterology guideline on the management of Helicobacter pylori infection. Am J Gastroenterol. 2007;102(8):1808-1825. doi:10.1111/j.1572-0241.2007.01393.x
  • 16. Albayrak M, Karatas A, Demiraran Y, et al. Ghrelin, acylated ghrelin, leptin and PYY-3 levels in hyperemesis gravidarum. J Matern-Fetal Neonatal Med Off J Eur Assoc Perinat Med Fed Asia Ocean Perinat Soc Int Soc Perinat Obstet. 2013;26(9):866-870. doi:10.3109/14767058.2013.766699
  • 17. Ege S, Kolusarı A, Buğdaycı G, et al. Ghrelin does not change in hyperemesis gravidarum. Ginekol Pol. 2019;90(12):699-701. doi:10.5603/GP.2019.0119
  • 18. Ozturk G, Ozgu-Erdinc AS, Ucar F, Ginis Z, Erden G, Danisman N. Concentrations of prealbumin and some appetite-controlling hormones in pregnancies associated with hyperemesis gravidarium. Ann Clin Biochem. 2017;54(2):258-263. doi:10.1177/0004563216654724
  • 19. Köşüş A, Köşüş N, Usluoğullari B, Hizli D, Namuslu M, Ayyildiz A. Gut satiety hormones and hyperemesis gravidarum. Arch Gynecol Obstet. 2015;292(6):1225-1230. doi:10.1007/s00404-015-3751-9
  • 20. Gungor S, Gurates B, Aydin S, et al. Ghrelins, obestatin, nesfatin-1 and leptin levels in pregnant women with and without hyperemesis gravidarum. Clin Biochem. 2013;46(9):828-830. doi:10.1016/j.clinbiochem.2013.01.015
  • 21. Unsel N, Benian A, Erel CT. Leptin levels in women with hyperemesis gravidarum. Int J Gynaecol Obstet Off Organ Int Fed Gynaecol Obstet. 2004;84(2):162-163. doi:10.1016/S0020-7292(03)00140-1
  • 22. Demir B, Erel CT, Haberal A, Oztürk N, Güler D, Koçak M. Adjusted leptin level (ALL) is a predictor for hyperemesis gravidarum. Eur J Obstet Gynecol Reprod Biol. 2006;124(2):193-196. doi:10.1016/j.ejogrb.2004.11.012
  • 23. Aka N, Atalay S, Sayharman S, Kiliç D, Köse G, Küçüközkan T. Leptin and leptin receptor levels in pregnant women with hyperemesis gravidarum. Aust N Z J Obstet Gynaecol. 2006;46(4):274-277. doi:10.1111/j.1479-828X.2006.00590.x
  • 24. Baron TH, Ramirez B, Richter JE. Gastrointestinal motility disorders during pregnancy. Ann Intern Med. 1993;118(5):366-375. doi:10.7326/0003-4819-118-5-199303010-00008
  • 25. Christofides ND, Ghatei MA, Bloom SR, Borberg C, Gillmer MD. Decreased plasma motilin concentrations in pregnancy. Br Med J Clin Res Ed. 1982;285(6353):1453-1454. doi:10.1136/bmj.285.6353.1453
  • 26. Oruç AS, Mert I, Akturk M, et al. Ghrelin and motilin levels in hyperemesis gravidarum. Arch Gynecol Obstet. 2013;287(6):1087-1092. doi:10.1007/s00404-012-2705-8
  • 27. Poveda GF, Carrillo KS, Monje ME, Cruz CA, Cancino AG. Helicobacter pylori infection and gastrointestinal symptoms on Chilean pregnant women. Rev Assoc Medica Bras 1992. 2014;60(4):306-310. doi:10.1590/1806-9282.60.04.008
  • 28. Kazerooni T, Taallom M, Ghaderi AA. Helicobacter pylori seropositivity in patients with hyperemesis gravidarum. Int J Gynaecol Obstet Off Organ Int Fed Gynaecol Obstet. 2002;79(3):217-220. doi:10.1016/s0020-7292(02)00298-9
  • 29. Grooten IJ, Den Hollander WJ, Roseboom TJ, et al. Helicobacter pylori infection: a predictor of vomiting severity in pregnancy and adverse birth outcome. Am J Obstet Gynecol. 2017;216(5):512.e1-512.e9. doi:10.1016/j.ajog.2017.01.042
  • 30. Jacobson GF, Autry AM, Somer-Shely TL, Pieper KL, Kirby RS. Helicobacter pylori seropositivity and hyperemesis gravidarum. J Reprod Med. 2003;48(8):578-582.
  • 31. Ioannidou P, Papanikolaou D, Mikos T, Mastorakos G, Goulis DG. Predictive factors of Hyperemesis Gravidarum: A systematic review. Eur J Obstet Gynecol Reprod Biol. 2019;238:178-187. doi:10.1016/j.ejogrb.2019.04.043

Correlation between Helicobacter pylori and serum levels of ghrelin, obestatin, leptin and motilin in hyperemesis gravidarum

Year 2024, Volume: 3 Issue: 1, 306 - 311, 29.03.2024

Abstract

Introductıon: Hyperemesis gravidarum (HEG) is the severe form of nausea and vomiting seen in pregnancy. Many factors are thought to affect the development of the disease however, the pathogenesis of HEG has not been clearly revealed yet. In this study, we aimed to evaluate serum ghrelin, obestatin, leptin, motilin levels and their relationship with Helicobacter pylori (H.pylori) in the patients diagnosed with HEG.
Methods: A total of 160 patients including 48 HEG patients, 57 asymptomatic pregnant women, and 55 healthy non-pregnant women aged between 18-40 years, who were admitted to our tertiary research hospital were included in the study, Gastrointestinal hormone levels compared between three groups and the HEG group divided by the H.pylori seropositivity and hormone levels were compared between H.pylori positive and negative patients.
Results: In the HEG group, the mean serum ghrelin level was significantly lower and the mean leptin level was significantly higher than the asymptomatic pregnant and non-pregnant control groups (p=0.0001 and p=0.0001). The mean obestatin level of the HEG group was significantly lower than the non-pregnant control group (p=0.012). The mean motilin level in the HEG group was significantly higher compared to the asymptomatic pregnant control group (p=0.020).
Conclusion: This study suggests a possible role of ghrelin, obestatin, leptin and motilin in the pathology of HEG independent from H.pylori positivity.

References

  • 1. Matthews A, Dowswell T, Haas DM, Doyle M, O’Mathúna DP. Interventions for nausea and vomiting in early pregnancy. Cochrane Database Syst Rev. 2010;(9):CD007575. doi:10.1002/14651858.CD007575.pub2
  • 2. London V, Grube S, Sherer DM, Abulafia O. Hyperemesis Gravidarum: A Review of Recent Literature. Pharmacology. 2017;100(3-4):161-171. doi:10.1159/000477853
  • 3. Pham A, Okpara R, Rollins N, Jacob R. Intrauterine Fetal Demise: A Rare Complication of Wernicke’s Encephalopathy Secondary to Hyperemesis Gravidarum. Cureus. 2023;15(10):e47270. doi:10.7759/cureus.47270
  • 4. Heitmann K, Nordeng H, Havnen GC, Solheimsnes A, Holst L. The burden of nausea and vomiting during pregnancy: severe impacts on quality of life, daily life functioning and willingness to become pregnant again – results from a cross-sectional study. BMC Pregnancy Childbirth. 2017;17(1):75. doi:10.1186/s12884-017-1249-0
  • 5. Dodds L, Fell DB, Joseph KS, Allen VM, Butler B. Outcomes of pregnancies complicated by hyperemesis gravidarum. Obstet Gynecol. 2006;107(2 Pt 1):285-292. doi:10.1097/01.AOG.0000195060.22832.cd
  • 6. Jansen LAW, Nijsten K, Limpens J, et al. Perinatal outcomes of infants born to mothers with hyperemesis gravidarum: A systematic review and meta-analysis. Eur J Obstet Gynecol Reprod Biol. 2023;284:30-51. doi:10.1016/j.ejogrb.2023.03.004
  • 7. Lee NM, Saha S. Nausea and vomiting of pregnancy. Gastroenterol Clin North Am. 2011;40(2):309-334, vii. doi:10.1016/j.gtc.2011.03.009
  • 8. Briggs DI, Andrews ZB. Metabolic status regulates ghrelin function on energy homeostasis. Neuroendocrinology. 2011;93(1):48-57. doi:10.1159/000322589
  • 9. Zhang JV, Ren PG, Avsian-Kretchmer O, et al. Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin’seffects on food intake. Science. 2005;310(5750):996-999. doi:10.1126/science.1117255
  • 10. Caro JF, Sinha MK, Kolaczynski JW, Zhang PL, Considine RV. Leptin: the tale of an obesity gene. Diabetes. 1996;45(11):1455-1462. doi:10.2337/diab.45.11.1455
  • 11. Mantzoros CS, Dunaif A, Flier JS. Leptin concentrations in the polycystic ovary syndrome. J Clin Endocrinol Metab. 1997;82(6):1687-1691. doi:10.1210/jcem.82.6.4017
  • 12. Peeters TL, Muls E, Janssens J, et al. Effect of motilin on gastric emptying in patients with diabetic gastroparesis. Gastroenterology. 1992;102(1):97-101. doi:10.1016/0016-5085(92)91788-6
  • 13. Luiking YC, Peeters TL, Stolk MF, et al. Motilin induces gall bladder emptying and antral contractions in the fasted state in humans. Gut. 1998;42(6):830-835. doi:10.1136/gut.42.6.830
  • 14. Cave DR. Transmission and epidemiology of Helicobacter pylori. Am J Med. 1996;100(5A):12S-17S; discussion 17S-18S. doi:10.1016/s0002-9343(96)80224-5
  • 15. Chey WD, Wong BCY, Practice Parameters Committee of the American College of Gastroenterology. American College of Gastroenterology guideline on the management of Helicobacter pylori infection. Am J Gastroenterol. 2007;102(8):1808-1825. doi:10.1111/j.1572-0241.2007.01393.x
  • 16. Albayrak M, Karatas A, Demiraran Y, et al. Ghrelin, acylated ghrelin, leptin and PYY-3 levels in hyperemesis gravidarum. J Matern-Fetal Neonatal Med Off J Eur Assoc Perinat Med Fed Asia Ocean Perinat Soc Int Soc Perinat Obstet. 2013;26(9):866-870. doi:10.3109/14767058.2013.766699
  • 17. Ege S, Kolusarı A, Buğdaycı G, et al. Ghrelin does not change in hyperemesis gravidarum. Ginekol Pol. 2019;90(12):699-701. doi:10.5603/GP.2019.0119
  • 18. Ozturk G, Ozgu-Erdinc AS, Ucar F, Ginis Z, Erden G, Danisman N. Concentrations of prealbumin and some appetite-controlling hormones in pregnancies associated with hyperemesis gravidarium. Ann Clin Biochem. 2017;54(2):258-263. doi:10.1177/0004563216654724
  • 19. Köşüş A, Köşüş N, Usluoğullari B, Hizli D, Namuslu M, Ayyildiz A. Gut satiety hormones and hyperemesis gravidarum. Arch Gynecol Obstet. 2015;292(6):1225-1230. doi:10.1007/s00404-015-3751-9
  • 20. Gungor S, Gurates B, Aydin S, et al. Ghrelins, obestatin, nesfatin-1 and leptin levels in pregnant women with and without hyperemesis gravidarum. Clin Biochem. 2013;46(9):828-830. doi:10.1016/j.clinbiochem.2013.01.015
  • 21. Unsel N, Benian A, Erel CT. Leptin levels in women with hyperemesis gravidarum. Int J Gynaecol Obstet Off Organ Int Fed Gynaecol Obstet. 2004;84(2):162-163. doi:10.1016/S0020-7292(03)00140-1
  • 22. Demir B, Erel CT, Haberal A, Oztürk N, Güler D, Koçak M. Adjusted leptin level (ALL) is a predictor for hyperemesis gravidarum. Eur J Obstet Gynecol Reprod Biol. 2006;124(2):193-196. doi:10.1016/j.ejogrb.2004.11.012
  • 23. Aka N, Atalay S, Sayharman S, Kiliç D, Köse G, Küçüközkan T. Leptin and leptin receptor levels in pregnant women with hyperemesis gravidarum. Aust N Z J Obstet Gynaecol. 2006;46(4):274-277. doi:10.1111/j.1479-828X.2006.00590.x
  • 24. Baron TH, Ramirez B, Richter JE. Gastrointestinal motility disorders during pregnancy. Ann Intern Med. 1993;118(5):366-375. doi:10.7326/0003-4819-118-5-199303010-00008
  • 25. Christofides ND, Ghatei MA, Bloom SR, Borberg C, Gillmer MD. Decreased plasma motilin concentrations in pregnancy. Br Med J Clin Res Ed. 1982;285(6353):1453-1454. doi:10.1136/bmj.285.6353.1453
  • 26. Oruç AS, Mert I, Akturk M, et al. Ghrelin and motilin levels in hyperemesis gravidarum. Arch Gynecol Obstet. 2013;287(6):1087-1092. doi:10.1007/s00404-012-2705-8
  • 27. Poveda GF, Carrillo KS, Monje ME, Cruz CA, Cancino AG. Helicobacter pylori infection and gastrointestinal symptoms on Chilean pregnant women. Rev Assoc Medica Bras 1992. 2014;60(4):306-310. doi:10.1590/1806-9282.60.04.008
  • 28. Kazerooni T, Taallom M, Ghaderi AA. Helicobacter pylori seropositivity in patients with hyperemesis gravidarum. Int J Gynaecol Obstet Off Organ Int Fed Gynaecol Obstet. 2002;79(3):217-220. doi:10.1016/s0020-7292(02)00298-9
  • 29. Grooten IJ, Den Hollander WJ, Roseboom TJ, et al. Helicobacter pylori infection: a predictor of vomiting severity in pregnancy and adverse birth outcome. Am J Obstet Gynecol. 2017;216(5):512.e1-512.e9. doi:10.1016/j.ajog.2017.01.042
  • 30. Jacobson GF, Autry AM, Somer-Shely TL, Pieper KL, Kirby RS. Helicobacter pylori seropositivity and hyperemesis gravidarum. J Reprod Med. 2003;48(8):578-582.
  • 31. Ioannidou P, Papanikolaou D, Mikos T, Mastorakos G, Goulis DG. Predictive factors of Hyperemesis Gravidarum: A systematic review. Eur J Obstet Gynecol Reprod Biol. 2019;238:178-187. doi:10.1016/j.ejogrb.2019.04.043
There are 31 citations in total.

Details

Primary Language English
Subjects Traditional, Complementary and Integrative Medicine (Other)
Journal Section Research Articles
Authors

Osman Onur Özkavak 0000-0001-9259-7825

Fatma Beyazıt 0000-0002-0667-6090

Publication Date March 29, 2024
Submission Date January 12, 2024
Acceptance Date March 4, 2024
Published in Issue Year 2024 Volume: 3 Issue: 1

Cite

EndNote Özkavak OO, Beyazıt F (March 1, 2024) Correlation between Helicobacter pylori and serum levels of ghrelin, obestatin, leptin and motilin in hyperemesis gravidarum. ACH Medical Journal 3 1 306–311.