Molar Kesici Hipomineralizasyonu’ndan Etkilenmiş Dişlerde Remineralizasyon ve Hassasiyet Giderici Ajanların Değerlendirilmesi

Year 2024, Volume: 13 Issue: 1, 191 - 201, 26.01.2024

Erenay Alpayçetin Elif Tuna

https://doi.org/10.54617/adoklinikbilimler.1307899

Abstract

ÖZET
Molar Kesici Hipomineralizasyonu bir veya birden fazla birinci büyük azı ve kesici dişlerde, sınırları belirgin hipomineralize defektlerle karakterize gelişimsel bir mine defektidir. MIH’lı dişlerin mine yapısındaki kalsiyum ve fosfor konsantrasyonu sağlıklı mine ile kıyaslandığında daha düşüktür. Bu dişlerde remineralizasyonu sağlamak amacıyla günümüzde birçok koruyucu yöntem ve ajan ön plana çıkmaktadır. Aynı zamanda artmış porözite ve azalmış mine kalınlığı sebebiyle MIH’tan etkilenmiş dişlerde şiddetli derecede hassasiyet gözlenmektedir. Hassasiyetin ve ağrının yönetiminde koruyucu uygulamalardan, çekime kadar geniş tedavi seçenekleri söz konusudur. Bu derlemede MIH’tan etkilenmiş dişlerde yaşanan aşırı hassasiyetin üstesinden gelinmesi ve remineralizasyonu artırma stratejileri için literatürde yer alan önerilerin tanıtılması amaçlanmıştır.

Keywords

Ağrı, Diş minesi hipoplazisi, Diş remineralizasyonu

Evaluation of Remineralization and Desensitizing Agents in Molar Incisor Hypomineralization-Affected Teeth

Abstract

ABSTRACT
Molar Incisor Hypomineralization (MIH) is a developmental enamel defect characterized by prominent hypomineralized defects in one or more first permanent molars and permanent incisors. The enamel structure of MIH-affected teeth exhibits lower concentrations of calcium and phosphates compared to sound enamel. Various preventive methods and agents have emerged today to facilitate remineralization in these teeth. Moreover, the increased porosity and reduced enamel thickness in MIH-affected teeth result in severe sensitivity. Management options for addressing sensitivity and pain in these cases encompass a broad range of treatments, ranging from preventive methods to tooth extraction. This review aims to present recommendations from the existing literature for mitigating the hypersensitivity experienced in MIH-affected teeth, as well as outlining strategies to enhance remineralization.

Keywords

Pain, Dental Enamel Hypoplasia, Tooth Remineralization

References

• Referans1. Güner Ş, Salcıoğlu D. Current View on the Diagnosis and Treatment of Molar Incisor Hypomineralization. Clin Exp Health Sci 2016;6:28-34
• Referans2. Mohamed RN, Basha S, Al-Thomali Y, Al Zahrani FS, Ashour AA, Al Shamrani AS, et al. Frequency of molar incisor hypomineralization and associated factors among children with special health care needs. Ann Saudi Med 2021;41:238-45.
• Referans3. Lygidakis NA, Garot E, Somani C, Taylor GD, Rouas P, Wong FSL. Best clinical practice guidance for clinicians dealing with children presenting with molar-incisor-hypomineralisation (MIH): an updated European Academy of Paediatric Dentistry policy document. Eur Arch Paediatr Dent 2022;23:3-21.
• Referans4. Rodd HD, Boissonade FM, Day PF. Pulpal status of hypomineralized permanent molars. Pediatr Dent 2007;29:514- 20.
• Referans5. Mahoney EK, Farah R. Planning and care for children and adolescents with dental enamel defects: etiology, research and contemporary management. Springer; 2015; p:73-84.
• Referans6. Jalevik B, Dietz W, Noren JG. Scanning electron micrograph analysis of hypomineralized enamel in permanent first molars. Int J Paediatr Dent 2005;15:233–40.
• Referans7. Suckling GW. Developmental defects of enamel–historical and present-day perspectives of their pathogenesis. Adv Dent Res 1989;3:87–94.
• Referans8. Mahoney EK, Ismail FS, Kilpatrick N, Swain M. Mechanical properties across hypomineralized/hypoplastic enamel of first permanent molar teeth. Eur J Oral Sci 2004;112:497–502.
• Referans9. Xie Z, Kilpatrick NM, Swain MV, Munroe PR, Hoffman M. Transmission electron microscope characterisation of molar-incisorhypomineralisation. J Mater Sci Mater Med 2008;19:3187–92.
• Referans10. Fearne J, Anderson P, Davis GR. 3D X-ray microscopic study of the extent of variations in enamel density in first permanent molars with idiopathic enamel hypomineralisation. Br Dent J 2004;196:634–8.
• Referans11. Farah RA, Drummond BK, Swain M, Williams S. Linking the clinical presentation of molar-incisor hypomineralisation to its mineral density. Int J Paediatr Dent 2010;5:353–60.
• Referans12. Jalevik B, Noren JG. Enamel hypomineralization of permanent first molars: a morphological study and survey of possible aetiological factors. Int J Paediatr Dent 2000;10:278–89.
• Referans13. Crombie FA, Cochrane NJ, Manton DJ, Palamara JE, Reynolds EC. Mineralisation of developmentally hypomineralised human enamel in vitro. Caries Res 2013;47:259–63.
• Referans14. Jalevik B, Klingberg GA. Dental treatment, dental fear and behaviour management problems in children with severe enamel hypomineralization of their permanent first molars. Int J Paediatr Dent 2002;12:24–32.
• Referans15. Kilpatrick NM. New developments in understanding development defects of enamel: optimizing clinical outcomes. J Orthod 2009;36:277–82.
• Referans16. Rochel ID, Souza JG, Silva TC, Preira AF, Rios D, Buzalaf MA, et al. Effect of experimental xylitol and fluoride-contatining dentifrices on enamel erosion with or without abrasion in vitro. J Oral Sci 2011;53:163-8.
• Referans17. Weerheijm KL. Molar Incisor Hypomineralization (MIH): clinical presentation, aetiology and management. Dent Updat 2004;31:9–12.
• Referans18. McDonald S, Arkutu N, Malik K, Gadhia K, McKaig S. Managing the paediatric patient with amelogenesis imperfecta. Br Dent J 2012;212:425–8.
• Referans19. Steffen R, Kramer N, Bekes K. The Würzburg MIH concept: the MIH treatment need index (MIH TNI): A new index to assess and plan treatment in patieents with molar incisor hypomineralisation (MIH). Eur Arch Paediatr Dent 2017;18:355-61.
• Referans20. Wang LJ, Tang R, Bonstein T, Bush P, Nancollas GH. Enamel demineralization in primary and permanent teeth. J Dent Res 2006;85:359–63.
• Referans21. Salanitri S, Seow WK. Developmental enamel defects in the primary dentition: aetiology and clinical management. Aust Dent J 2013;58:133–40.
• Referans22. Wright JT. Amelogenesis imperfecta. Eur J Oral Sci 2011;119:338–41.
• Referans23. Elfrink MEC, ten Cate JM, van Ruijven LJ, Veerkamp JSJ. Mineral content in teeth with Deciduous Molar Hypomineralisation (DMH). J Dent 2013;41:974–8.
• Referans24. Featherstone JDB. Remineralization, the natural caries repair process – the need for new approaches. Adv Dent Res 2009;21:4–7.
• Referans25. Oliver K, Messer LB, Manton DJ, Kan K, Ng F, Olsen C, et al. Distribution and severity of molar hypomineralisation: trial of a new severity index. Int J Paediatr Dent 2014;24:131– 51.
• Referans26. Linner T, Khazaei Y, Bücher K, Pfisterer J, Hickel R, Kühnisch J. Hypersensitivity in teeth affected by molar-incisor hypomineralization (MIH). Sci Rep 2021;11:17922.
• Referans27. Bekes K, Heinzelmann K, Lettner S, Schaller HG. Efficacy of desensitizing products containing 8% arginine and calcium carbonate for hypersensitivity relief in MIH-affected molars: an 8-week clinical study. Clin Oral Investig 2017;21:2311-7.
• Referans28. Bekes K, Amend S, Priller J, Zamek C, Stamm T, Krämer N. Hypersensitivity relief of MIH-affected molars using two sealing techniques: a 12-week follow-up. Clin Oral Investig 2022;26:1879- 88.
• Referans29. Ozgül BM, Saat S, Sönmez H, Oz FT. Clinical evaluation of desensitizing treatment for incisor teeth affected by molar-incisor hypomineralization. J Clin Pediatr Dent 2013;38:101-5.
• Referans30. Muniz RSC, Carvalho CN, Aranha ACC, Dias FMCS, Ferreira MC. Efficacy of low-level laser therapy associated with fluoride therapy for the desensitisation of molar-incisor hypomineralisation: Randomised clinical trial. Int J Paediatr Dent 2020;30:323-33.
• Referans31. Ehlers V, Reuter AK, Kehl EB, Enax J, Meyer F, Schlecht J, et al. Efficacy of a Toothpaste Based on Microcrystalline Hydroxyapatite on Children with Hypersensitivity Caused by MIH: A Randomised Controlled Trial. Oral Health Prev Dent 2021;19:647-58.
• Referans32. Vicioni-Marques F, Paula-Silva FWG, Carvalho MR, Queiroz AM, Freitas O, Duarte MPF, et al. Preemptive analgesia with ibuprofen increases anesthetic efficacy in children with severe molar: a triple-blind randomized clinical trial. J Appl Oral Sci 2022;20:e20210538.
• Referans33. Vieira AEM, Danelon M, Camara DMD, Rosselli ER, Stock SR, Cannon ML, et al. In vitro effect of amorphous calcium phosphate paste applied for extended periods of time on enamel remineralization. J Appl Oral Sci 2017;25:596-603.
• Referans34. Bostancı B, Korkut E, Ünlü N. Başlangıç Mine Lezyonlarının Florür İçermeyen ve İnvaziv Olmayan Tedavi Yöntemleri. Türkiye Klinikleri J Restor Dent – Special Topics 2017;3: 7-13.
• Referans35. Uysal S., Tulga F. Derleme: Başlangıç Mine Lezyonlarının Remineralizasyonunda Kullanılan Ajanlar. AÜ Diş Hek Fak Derg 2018;45:201-10.
• Referans36. Biondi AM, Cortese SG, Babino L, Fridman DE. Comparison of Mineral Density in Molar Incisor Hypomineralization applying fluoride varnishes and casein phosphopeptide-amorphous calcium phosphate. Comparación de Densidad Mineral en Hipomineralización Molar Incisiva aplicando barnices fluorados y fosfopéptidos de caseína-fosfato de calcio amorfo. Acta Odontol Latinoam 2017;30:118-23.
• Referans37. Sezer B, Kargul B. Effect of Remineralization Agents on Molar- Incisor Hypomineralization-Affected Incisors: A Randomized Controlled Clinical Trial. J Clin Pediatr Dent 2022;46:192-98.
• Referans38. Amaechi BT, Farah R, Liu JA, Philips TS, Perozo BI, Kataoka Y, et al. Remineralization of molar incisor hypomineralization (MIH) with a hydroxyapatite toothpaste: an in-situ study. BDJ Open 2022;8:33.
• Referans39. Restrepo M, Jeremias F, Santos-Pinto L, Cordeiro RC, Zuanon AC. Effect of Fluoride Varnish on Enamel Remineralization in Anterior Teeth with Molar Incisor Hypomineralization. J Clin Pediatr Dent 2016;40:207-10.
• Referans40. Singh SK, Goyal A, Gauba K, Rathore M. A Comparative Evaluation of CPP-ACP Cream and Fluoride Varnish in Remineralization of MIH-affected Teeth Using Laser Fluorescence. Pediatr Dent 2021;4:117-21.
• Referans41. Kumar A, Goyal A, Gauba K, Kapur A, Singh SK, Mehta SK. An evaluation of remineralised MIH using CPP-ACP and fluoride varnish: An in-situ and in-vitro study. Eur Arch Paediatr Dent 2022;23:79-87.
• Referans42. Olgen IC, Sonmez H, Bezgin T. Effects of different remineralization agents on MIH defects: a randomized clinical study. Clin Oral Investig 2022;26:3227-38.
• Referans43. Cardoso-Martins I, Arantes-Oliveira S, Coelho A, Pessanha S, F Marques P. Evaluation of the Efficacy of CPP-ACP Remineralizing Mousse in MIH White and Yellow Opacities-In Vitro Vickers Microhardness Analysis. Dent J (Basel) 2022;10:186.