İlaçlara Bağlı Gelişen Çene Kemiği Osteonekrozlarının Yönetiminde Güncel Değişimler

Year 2024, Volume: 13 Issue: 1, 202 - 219, 26.01.2024

Onur Şahin Mustafa Hacılar

https://doi.org/10.54617/adoklinikbilimler.1313173

Abstract

Antirezorptif ilaçlar osteoporoz, Paget hastalığı gibi kemik metabolizmasını ilgilendiren hastalıkların tedavisinde ve metastatik kemik tümörlerinin önlenmesinde hastaların hayat kalitesini arttırmak ve ağrı şikayetlerini azaltmak amacı ile sıklıkla tercih edilen ilaçlardır. Antirezorptif ilaç kullanımına bağlı olarak gelişen osteonekroz (İÇKON) olguları 2000’li yıllardan itibaren artış göstermeye başlamıştır. Bu hastalığın patofizyolojisinin net olmaması kesin bir tedavi protokolünün olmamasına sebep olmuştur. Amerikan Oral ve Maksillofasiyal Cerrahi Derneği (AAOMS) 2007, 2009 ve 2014 yıllarında ilaçlara bağlı İÇKON ile ilişkili görüş bildirgeleri yayınlamıştır. Bu derlemenin amacı İÇKON olgularının etiyolojisini, klinik ve radyolojik bulgularını, risk faktörlerini ve farklı tedavi seçeneklerini 2022 yılında yayınlanan son güncellemeye göre değerlendirmektir.

Keywords

İlaçlara bağlı gelişen çene kemiği osteonekrozu, Tedavi, Korunma

Current Changes in the Management of Medication Related Osteonecrosis of the Jaw

Abstract

Antiresorptive drugs are frequently preferred in the treatment of diseases related to bone metabolism such as osteoporosis and Paget's disease, and in the prevention of metastatic bone tumors, to increase the quality of life of patients and to reduce pain complaints. Osteonecrosis cases due to the use of antiresorptive drugs (MRONJ) have started to increase since the 2000s. The unclear pathophysiology of this disease has led to the lack of a definitive treatment protocol. The American Associaton of Oral and Maxillofacial Surgeons (AAOMS) published position paper regarding medication related osteonecrosis of the jaw in 2007, 2009 and 2014. The aim of this review is to evaluate the etiology, clinical and radiological findings, risk factors and different treatment options of MRONJ cases according to the last update published in 2022.

Keywords

Medication related osteonecrosis of the jaw, Treatment, Prevention

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