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Elektroeğrilmiş Nanofiber Yapıların Kanser Tedavisinde Kullanımı: Mevcut İlerlemeler ve Gelecek Persfektifler

Year 2023, Volume: 3 Issue: 2, 39 - 55, 21.11.2023

Abstract

Nanoteknoloji, tıp bilimleri dahil olmak üzere hayatın hemen her alanında önemli bir rol oynamıştır. Nanoteknolojik ürünlerin önemli bir sınıfını da nanofiberler oluşturmaktadır. Nanofiberlerle biyomedikal uygulamalarla ilgili başlıca araştırma hatları, kontrollü ilaç salım uygulamaları için antitümör ilaçların kapsüllenmesini, doku mühendisliği ve rejeneratif tıp için iskele yapılarını ve ayrıca kanser tümörlerinin azaltılmasında uygulanacak manyetik veya plazmonik hipertermiyi kapsamaktadır. Özellikle, kemoterapide kullanılan genel antikanser ilaçlarının, yüksek doz kullanımları ile ciddi yan etkilerle ilişkili olması ve normal hücrelere de zarar vermesinden dolayı, kontrollü ve sürekli bir ilaç salınımı, faydalar sağlamaktadır. Bu amaçla kullanılan antikanser ilacı yüklü nanofiberler, ilacın daha uzun süre korunmasını ve daha az ilaçla sonuca ulaşılmasını sağladığı için önemli sonuçlara ulaşılmıştır. Elektrospun nanofiberler, çok geniş yüzey alanına, kontrol edilebilir gözenek boyutuna ve ayarlanabilir ilaç salım profillerine sahip olup, gelecek vadeden adaylardır. Elektroeğirme yönteminin nanofiber yapıları üretmede sunduğu göreceli kolaylık, farklı polimer yapıların, polimer veya inorganik maddelerin kompozit olarak kullanılabilmeleri, farklı boyut, şekil, gözenek boyutlarında üretilebilmeleri, dış ve/veya iç uyaranlara (pH, sıcaklık, manyetik alan, ışık vb.) yanıt verme yeteneklerine sahip olabilmeleri, yeni stratejilerin ve yeni araştırmaların sayısını oldukça arttırmaktadır. Bunun yanında, nanofiberlerin kanser tedavisinde uygulanmasına ilişkin çok sayıda araştırma raporu bulunmaktadır. Bu derleme makale, başarılı kanser tedavisi için rapor edilmiş, bazı elektrospun nanofiberlere genel bir yaklaşımla odaklanmaktadır.

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Year 2023, Volume: 3 Issue: 2, 39 - 55, 21.11.2023

Abstract

Project Number

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There are 137 citations in total.

Details

Primary Language Turkish
Journal Section Reviews
Authors

Gökmen Arabacı 0000-0002-5848-6117

Sumeray Ayan

Fatma Gündüz 0000-0002-2642-8916

Yasemin İspirli Doğaç 0000-0001-8616-0280

Project Number -
Publication Date November 21, 2023
Published in Issue Year 2023 Volume: 3 Issue: 2

Cite

APA Arabacı, G., Ayan, S., Gündüz, F., İspirli Doğaç, Y. (2023). Elektroeğrilmiş Nanofiber Yapıların Kanser Tedavisinde Kullanımı: Mevcut İlerlemeler ve Gelecek Persfektifler. Ata-Kimya Dergisi, 3(2), 39-55.
AMA Arabacı G, Ayan S, Gündüz F, İspirli Doğaç Y. Elektroeğrilmiş Nanofiber Yapıların Kanser Tedavisinde Kullanımı: Mevcut İlerlemeler ve Gelecek Persfektifler. J Ata-Chem. November 2023;3(2):39-55.
Chicago Arabacı, Gökmen, Sumeray Ayan, Fatma Gündüz, and Yasemin İspirli Doğaç. “Elektroeğrilmiş Nanofiber Yapıların Kanser Tedavisinde Kullanımı: Mevcut İlerlemeler Ve Gelecek Persfektifler”. Ata-Kimya Dergisi 3, no. 2 (November 2023): 39-55.
EndNote Arabacı G, Ayan S, Gündüz F, İspirli Doğaç Y (November 1, 2023) Elektroeğrilmiş Nanofiber Yapıların Kanser Tedavisinde Kullanımı: Mevcut İlerlemeler ve Gelecek Persfektifler. Ata-Kimya Dergisi 3 2 39–55.
IEEE G. Arabacı, S. Ayan, F. Gündüz, and Y. İspirli Doğaç, “Elektroeğrilmiş Nanofiber Yapıların Kanser Tedavisinde Kullanımı: Mevcut İlerlemeler ve Gelecek Persfektifler”, J Ata-Chem, vol. 3, no. 2, pp. 39–55, 2023.
ISNAD Arabacı, Gökmen et al. “Elektroeğrilmiş Nanofiber Yapıların Kanser Tedavisinde Kullanımı: Mevcut İlerlemeler Ve Gelecek Persfektifler”. Ata-Kimya Dergisi 3/2 (November 2023), 39-55.
JAMA Arabacı G, Ayan S, Gündüz F, İspirli Doğaç Y. Elektroeğrilmiş Nanofiber Yapıların Kanser Tedavisinde Kullanımı: Mevcut İlerlemeler ve Gelecek Persfektifler. J Ata-Chem. 2023;3:39–55.
MLA Arabacı, Gökmen et al. “Elektroeğrilmiş Nanofiber Yapıların Kanser Tedavisinde Kullanımı: Mevcut İlerlemeler Ve Gelecek Persfektifler”. Ata-Kimya Dergisi, vol. 3, no. 2, 2023, pp. 39-55.
Vancouver Arabacı G, Ayan S, Gündüz F, İspirli Doğaç Y. Elektroeğrilmiş Nanofiber Yapıların Kanser Tedavisinde Kullanımı: Mevcut İlerlemeler ve Gelecek Persfektifler. J Ata-Chem. 2023;3(2):39-55.

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