Synthesis and Characterization of Natural Polymer Based Hydrogels

Year 2023, Volume: 6 Issue: 2, 111 - 119, 31.12.2023

Ömer Faruk Güder Betül Taşdelen Uğur Akyol

https://doi.org/10.55581/ejeas.1389940

Abstract

Soft tissue expanders, which have many uses in biomedical applications, are also encountered in surgical applications. Soft tissue expanders play an important role in ensuring osseointegration of dental implants. In this study, natural polymers chitosan (CS), hyaluronic acid (HA) and gelatin (GEL) were used. Synthesis of CS, CS-HA, CS-GEL, GEL-HA and CS-HA-GEL hydrogels has been performed. Gamma radiation was used in hydrogel synthesis with HAP. They were characterized by Fourier Transform Infrared Spectroscopy (FTIR) and Scanning Electron Microscopy (SEM). Dynamic swelling tests were performed in distilled water. Swelling behavior and swelling kinetics of hydrogels were determined. The effect of cross-linker concentration and different cross-linkers (glutaraldehyde (GA) and hydroxyapatite (HAP)) on swelling behavior was evaluated. Fickian mechanism has been observed in the diffusion of hydrogels. The results show that the hydrophilic CS-HA-1 hydrogel with the highest mass swelling and the most suitable swelling profile can be used as a soft tissue expander in biomedical applications.

Keywords

Hydrogel, Natural polymers, Soft tissue expansion, Tissue expander

Doğal Polimer Bazlı Hidrojellerin Sentezi ve Karakterizasyonu

Abstract

Biyomedikal uygulamalarda pek çok kullanımı bulunan yumuşak doku genişleticiler cerrahi uygulamalarda karşımıza çıkmaktadır. Dental implantların osseointegrasyonunun sağlanmasında yumuşak doku genişleticiler önemli bir rol oynamaktadır. Bu çalışmada, kitosan (CS), hyaluronik asit (HA) ve jelatin (GEL) doğal polimerleri kullanılmıştır. CS, CS-HA, CS-GEL, GEL-HA ve CS-HA-GEL hidrojellerinin sentezi gerçekleştirilmiştir. HAP ile hidrojel sentezinde gama radyasyon kullanılmıştır. Fourier Dönüşümlü Kızılötesi Spektroskopisi (FTIR) ve Taramalı Elektron Mikroskobu (SEM) ile karakterizasyonları yapılmıştır. Dinamik şişme testleri distile suda gerçekleştirilmiştir. Hidrojellerin şişme davranışları ve şişme kinetikleri belirlenmiştir. Çapraz bağlayıcı konsantrasyonunun ve farklı çapraz bağlayıcıların (glutaraldehit (GA) ve hidroksiapatit (HAP)) şişme davranışına etkisi değerlendirilmiştir. Hidrojellerin difüzyonunda Fickian mekanizması görülmüştür. Sonuçlar, en yüksek kütlece şişmeye ve en uygun şişme profiline sahip hidrofilik yapılı CS-HA-1 hidrojelinin biyomedikal uygulamalarda yumuşak doku genişletici olarak kullanılabileceği göstermektedir..

Keywords

Doğal polimerler, Doku genişletici, Hidrojel, Yumuşak doku genişlemesi

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