Research Article
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Assessment of Depression and Anxiety After Botulinum Toxin Injection Treatment in Patients with Hemifacial Spasm and Blepharospasm

Year 2024, Volume: 16 Issue: 1, 1 - 10, 30.04.2024
https://doi.org/10.56484/iamr.1446484

Abstract

Objective: The aim of this study was to investigate the relationship between depression and anxiety due to the current clinical situation, disease duration and age, and the change in post-treatment parameters in patients with hemifacial spasm (HS) and blepharospasm (BS) receiving botulinum toxin therapy (BTT).
Materials and methods: 125 hemifacial spasm patients, 14 blepharospasm patients and 70 healthy volunteers were included in the study as control group. Beck depression and Beck anxiety scales were applied to the patient and control groups. The test was repeated in the patient group 4 weeks after BTT treatment.
Results: The Beck anxiety and Beck depression scale scores of the case group were higher before treatment compared to the control group. Beck anxiety and Beck depression scores decreased after treatment in both HS and BS patients. Among the groups, the post-treatment Beck Anxiety score in the blepharospasm group was statistically significantly lower than in the hemifacial spasm group. The depression scale score increased with increasing disease duration in the case group. Anxiety and depression scores were lower in older patients. Beck depression and Beck anxiety scores of the patients improved with BTT treatment.
Conclusion: Since HS and BS cause physical problems in the facial muscles, it also negatively affects the functional status and emotional state of the patients. This disease is often accompanied by anxiety and/or depression. After CT treatment, functional muscle problems are corrected in HS and BS patients, providing positive effects on mood as well as the treatment of the disease and correcting the anxiety and depression findings related to the disease.

References

  • Yüksel G, Varlıbaş F, Gencer M, Delipoyraz İ, Çetinkaya Y, Tireli H. Research Article Clinical and Demographic Evaluation in Hemifacial Spasm and Blepharospasm Patients Haydarpasa Numune Education and Research Hospital, Department of Neurology, Istanbul, Türkiye, J.Neurol.Sci.[Turk] 300 Journal of Neurological Sciences [Turkish] 28:(3)
  • Eng-King Tan, M.D. Joseph Jankovic, M.D. Psychogenic Hemifacial Spasm The Journal of Neuropsychiatry and Clinical Neurosciences 2001; 13:380–384
  • Sayan P.K, Topçuoğlu V, Gımzal A, Göktepe E.A. Blefarospazm, Tourette Sendromu ve Obsesif Kompulsif Bozukluk: İki Olgu Sunumu, Klinik Psikiyatri 2004;7:57-60
  • Yılsen M, Meral H, Aydemir T, Çetin S, Tıras R, Özer F. Hemifasiyal Spazm ve Blefarospazm Olgularında Botulinum Toksin A Uygulamaları (Application of Botulinum Toxin A in the Patients Hemifacial Spasm and Blepharospasm) Haseki Tıp Bülteni, 2005
  • Ulusoy M, Sahin NH, Erkmen H. Turkish version of the Beck Anxiety Inventory: psychometric properties. J Cogn Psychotherapy 1998; 12:163–172.
  • Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J. An inventory for masuring depression. Arch Gen Psychiatry 1961; 4:561-71.
  • Hisli N. Beck Depresyon Envanterinin üniversite öğrencileri için geçerliliği, güvenilirliği. Psikoloji Dergisi 1989;7: 3-13.
  • Munhoz R.P, Teive H.AG, Della Coletta M.V et al. Frequency of obsessive and compulsive symptoms in patients with blepharospasm and hemifacial spasm
  • ŞanaL B, Gökalp G. Kaçar E. Parlak M. Vertebrobaziler Dolikoektaziye Bağlı Hemifasiyal Spazm Uludağ Üniversitesi Tıp Fakültesi Dergisi 30 (2) 137-140, 2004 137
  • Bihari K, Pigott TA, Hill JL, Murphy DL. Blepharospasm and obsessive-compulsive disorder. J Nerv Ment Dis 1992; 180:130– 132
  • Değirmenci T. Hemifasial spazm ve psikiyatrik komorbiditeler. Pam Tıp Derg 2022; 15:375-378
  • Holubova M, Prasko J, Ociskova M, Marackova M, Grambal A, Slepecky M. Self-stigma and quality of life in patients with depressive disorder: a cross-sectional study. Neuropsychiatr Dis Treat 2016; 12:2677-2687
  • Rudzińska M, Wójcik M, Szczudlik A. Hemifacial spasm non-motor and motor-related symptoms and their response to botulinum toxin therapy. J Neural Transm (Vienna) 2010; 117:765-772. http://doi.org/10.1007/ s00702-010-0416-5
  • Tan EK, Fook-Chong S, Lum SY. Case-control study of anxiety symptoms in hemifacial spasm. Mov Disord 2006;21(12):2145-2149
  • Scheidt CE, Schuller B, Rayki O, Kommerell G, Deuschl G. Relative absence of psychopathology in benign essential blepharospasm and hemifacial spasm. Neurology 1996; 47

HEMİFASİYAL SPAZM VE BLEFAROSPAZM HASTALARINDA BOTULİNUM TOKSİN ENJEKSİYONU TEDAVİSİ SONRASI DEPRESYON VE ANKSİYETE DURUMUNUN DEĞERLENDİRİLMESİ

Year 2024, Volume: 16 Issue: 1, 1 - 10, 30.04.2024
https://doi.org/10.56484/iamr.1446484

Abstract

Amaç: Botulinum toksin tedavisi (BTT) alan hemifasiyal spazm (HS) ve blefarospazm(BS) hastalarında mevcut klinik duruma bağlı oluşan depresyon ve anksiyete durumunun, hastalık süresi ve yaşla ilişkisi ve Post-treatment parametlerdeki değişimin araştırılması amaçlandı.
Gereç ve yöntem: Araştırmaya 125 hemifasiyal spazm, 14 blefarospazm hastası ,70 sağlıklı gönüllü kişi kontrol grubu olarak alındı. Hasta ve kontrol grubuna beck depresyon , beck anksiyete ölçekleri uygulandı. BTT tedavisinden 4 hafta sonra hasta grubuna test tekrarlandı.
Bulgular: Kontrol grubuna göre Pre-treatment vaka grubunun Beck anksiyete ve Beck depression scale puanı daha yüksekti. Hem HS hastalarında hem de BS hastalarında Post-treatment Beck anksiyete ve Beck depresyon skorları düşüş gösterdi. Gruplar arasında blefarospazm grubunda, Post-treatment Beck anxiety score hemifasiyal spazm grubundan istatistiksel anlamlı olarak daha düşük bulundu. Vaka grubunda hastalık süresi arttıkça depresyon ölçek puanı da artmaktaydı. İleri yaş hastalarda anksiyete ve depresyon skorlarının daha düşük olduğu gözlendi. BTT tedavisi ile hastaların Beck depresyon ve Beck anksiyete puanlarında iyileşme gözlendi.
Sonuç: HS ve BS hastalığı yüz kaslarında fiziksel sorunlara yol açtığı için hastaların aynı zamanda fonksiyonel durumları ve duygu durumunu da olumsuz etkilemektedir. Bu hastalığa genellikle anksiyete ve/veya depresyon eşlik etmektedir. BT tedavisi sonrası HS ve BS hastalarında fonksiyonel kas sorunları düzeltilerek hastalığın tedavisinin yanında duygu durum üzerine de olumlu etkiler sağlamakta ve hastalığa bağlı anksiyete ve depresyon bulgularını da düzeltmektedir

Ethical Statement

çalışmamız, yüzüncü yıl üniversitesi tıp fakültesi klinik araştırmalar etik kurul kararı ile 03 no ve 21/09/2022 etik kurul onayı alınmıştır.

References

  • Yüksel G, Varlıbaş F, Gencer M, Delipoyraz İ, Çetinkaya Y, Tireli H. Research Article Clinical and Demographic Evaluation in Hemifacial Spasm and Blepharospasm Patients Haydarpasa Numune Education and Research Hospital, Department of Neurology, Istanbul, Türkiye, J.Neurol.Sci.[Turk] 300 Journal of Neurological Sciences [Turkish] 28:(3)
  • Eng-King Tan, M.D. Joseph Jankovic, M.D. Psychogenic Hemifacial Spasm The Journal of Neuropsychiatry and Clinical Neurosciences 2001; 13:380–384
  • Sayan P.K, Topçuoğlu V, Gımzal A, Göktepe E.A. Blefarospazm, Tourette Sendromu ve Obsesif Kompulsif Bozukluk: İki Olgu Sunumu, Klinik Psikiyatri 2004;7:57-60
  • Yılsen M, Meral H, Aydemir T, Çetin S, Tıras R, Özer F. Hemifasiyal Spazm ve Blefarospazm Olgularında Botulinum Toksin A Uygulamaları (Application of Botulinum Toxin A in the Patients Hemifacial Spasm and Blepharospasm) Haseki Tıp Bülteni, 2005
  • Ulusoy M, Sahin NH, Erkmen H. Turkish version of the Beck Anxiety Inventory: psychometric properties. J Cogn Psychotherapy 1998; 12:163–172.
  • Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J. An inventory for masuring depression. Arch Gen Psychiatry 1961; 4:561-71.
  • Hisli N. Beck Depresyon Envanterinin üniversite öğrencileri için geçerliliği, güvenilirliği. Psikoloji Dergisi 1989;7: 3-13.
  • Munhoz R.P, Teive H.AG, Della Coletta M.V et al. Frequency of obsessive and compulsive symptoms in patients with blepharospasm and hemifacial spasm
  • ŞanaL B, Gökalp G. Kaçar E. Parlak M. Vertebrobaziler Dolikoektaziye Bağlı Hemifasiyal Spazm Uludağ Üniversitesi Tıp Fakültesi Dergisi 30 (2) 137-140, 2004 137
  • Bihari K, Pigott TA, Hill JL, Murphy DL. Blepharospasm and obsessive-compulsive disorder. J Nerv Ment Dis 1992; 180:130– 132
  • Değirmenci T. Hemifasial spazm ve psikiyatrik komorbiditeler. Pam Tıp Derg 2022; 15:375-378
  • Holubova M, Prasko J, Ociskova M, Marackova M, Grambal A, Slepecky M. Self-stigma and quality of life in patients with depressive disorder: a cross-sectional study. Neuropsychiatr Dis Treat 2016; 12:2677-2687
  • Rudzińska M, Wójcik M, Szczudlik A. Hemifacial spasm non-motor and motor-related symptoms and their response to botulinum toxin therapy. J Neural Transm (Vienna) 2010; 117:765-772. http://doi.org/10.1007/ s00702-010-0416-5
  • Tan EK, Fook-Chong S, Lum SY. Case-control study of anxiety symptoms in hemifacial spasm. Mov Disord 2006;21(12):2145-2149
  • Scheidt CE, Schuller B, Rayki O, Kommerell G, Deuschl G. Relative absence of psychopathology in benign essential blepharospasm and hemifacial spasm. Neurology 1996; 47
There are 15 citations in total.

Details

Primary Language English
Subjects Neurology and Neuromuscular Diseases
Journal Section Original Research Paper
Authors

Caner Baydar 0000-0002-4102-9155

Recep Yevgi 0000-0002-6586-2635

Özlem Karataş 0000-0003-3053-9333

Publication Date April 30, 2024
Submission Date March 3, 2024
Acceptance Date April 26, 2024
Published in Issue Year 2024 Volume: 16 Issue: 1

Cite

APA Baydar, C., Yevgi, R., & Karataş, Ö. (2024). Assessment of Depression and Anxiety After Botulinum Toxin Injection Treatment in Patients with Hemifacial Spasm and Blepharospasm. International Archives of Medical Research, 16(1), 1-10. https://doi.org/10.56484/iamr.1446484
AMA Baydar C, Yevgi R, Karataş Ö. Assessment of Depression and Anxiety After Botulinum Toxin Injection Treatment in Patients with Hemifacial Spasm and Blepharospasm. IAMR. April 2024;16(1):1-10. doi:10.56484/iamr.1446484
Chicago Baydar, Caner, Recep Yevgi, and Özlem Karataş. “Assessment of Depression and Anxiety After Botulinum Toxin Injection Treatment in Patients With Hemifacial Spasm and Blepharospasm”. International Archives of Medical Research 16, no. 1 (April 2024): 1-10. https://doi.org/10.56484/iamr.1446484.
EndNote Baydar C, Yevgi R, Karataş Ö (April 1, 2024) Assessment of Depression and Anxiety After Botulinum Toxin Injection Treatment in Patients with Hemifacial Spasm and Blepharospasm. International Archives of Medical Research 16 1 1–10.
IEEE C. Baydar, R. Yevgi, and Ö. Karataş, “Assessment of Depression and Anxiety After Botulinum Toxin Injection Treatment in Patients with Hemifacial Spasm and Blepharospasm”, IAMR, vol. 16, no. 1, pp. 1–10, 2024, doi: 10.56484/iamr.1446484.
ISNAD Baydar, Caner et al. “Assessment of Depression and Anxiety After Botulinum Toxin Injection Treatment in Patients With Hemifacial Spasm and Blepharospasm”. International Archives of Medical Research 16/1 (April 2024), 1-10. https://doi.org/10.56484/iamr.1446484.
JAMA Baydar C, Yevgi R, Karataş Ö. Assessment of Depression and Anxiety After Botulinum Toxin Injection Treatment in Patients with Hemifacial Spasm and Blepharospasm. IAMR. 2024;16:1–10.
MLA Baydar, Caner et al. “Assessment of Depression and Anxiety After Botulinum Toxin Injection Treatment in Patients With Hemifacial Spasm and Blepharospasm”. International Archives of Medical Research, vol. 16, no. 1, 2024, pp. 1-10, doi:10.56484/iamr.1446484.
Vancouver Baydar C, Yevgi R, Karataş Ö. Assessment of Depression and Anxiety After Botulinum Toxin Injection Treatment in Patients with Hemifacial Spasm and Blepharospasm. IAMR. 2024;16(1):1-10.

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