EFFICACY AND SAFETY OF POSTOPERATIVE INTRAVESICAL ADMINISTRATION OF TRANEXAMIC ACID AFTER TRANSURETHRAL RESECTION OF THE PROSTATE

Year 2023, Volume: 86 Issue: 4, 302 - 306, 01.12.2023

Yasin Yitgin Ayhan Karaköse

https://doi.org/10.26650/IUITFD.1326560

Abstract

Objective: To evaluate the safety and efficacy of postoperative intravesical administration of tranexamic acid after transurethral resection of the prostate.
Material and Method: The data of 112 patients who underwent surgery for lower urinary tract symptoms associated with benign prostatic obstruction (BPO) were retrospectively analysed. We formed two groups. Group 1 consisted of 57 patients who received tranexamic acid by irrigation fluid after the operation; group 2 consisted of 55 patients who did not receive tranexamic acid. Demographic data of patients and prostate characters, as well as operative and postoperative data were analysed. Postoperative bleeding in all patients was evaluated using the haemoglobin levels at the preoperative, and at 0- and 24-h postoperative were evaluated and noted.
Result: The mean ages of the patients were 66.9±7.2 (55-81) years in the intervention group, and those in the control group were 68.6±7.6 (55-80) years. There were no significant differences between the groups for demographic data, prostate volume and IPSS. The reduction in Hb at 24 hours postoperatively was greater in the control group compared to the TXA group. Statistically significant differences were found between the two groups in terms of postoperative haemoglobin decrease, bladder irrigation time and total amount of irrigation fluid. There were no statistically significant differences between each group regarding the operation, weight of resected adenoma, hospitalization time and catheter removal time.
Conclusion: A postoperative follow-up process with less bleeding and complications is possible with tranexamic acid added to the intravesical irrigation fluid used after TURP surgery.

Keywords

Tranexamic acid, transurethral resection of the prostate, irrigation fluid, postoperative bleeding

TRANSÜRETRAL PROSTAT REZEKSİYONU SONRASI POSTOPERATİF İNTRAVEZİKAL TRANEKSAMİK ASİT UYGULAMASININ ETKİNLİĞİ VE GÜVENLİĞİ

Abstract

Amaç: Benign prostat hiperplazili hastalarda transüretral prostat rezeksiyonu sonrası postoperatif intravezikal traneksamik asit uygulamasının güvenlik ve etkinliğini değerlendirmek.
Gereç ve Yöntem: Benign prostat hiperplazisine bağlı alt üriner sistem semptomları nedeniyle ameliyat edilen 112 hastanın verileri geriye dönük olarak incelendi. İki grup oluşturuldu. Grup 1'de operasyon sonrası irrigasyon sıvısı ile traneksamik asit uygulanan 57 hasta, grup 2'de traneksamik asit uygulanmayan 55 hasta mevcuttu. Hastaların demografik verileri, prostat özellikleri, operatif ve postoperatif verileri analiz edildi. Tüm hastalarda ameliyat sonrası takiplerindeki kanama miktarları; preoperatif ve postoperatif 0. ve 24. saatlerde hemoglobin düzeyleri kullanılarak değerlendirildi ve not edildi.
Bulgular: Traneksamik asit grubundaki hastaların yaş ortalaması 66,9±7,2 (55-81) yıl, kontrol grubundakiler ise 68,6±7,6 (55-80) yıl idi. Demografik veriler, prostat hacmi ve IPSS açısından gruplar arasında anlamlı fark yoktu. Postoperatif 24 saatte hemoglobindeki azalma, traneksamik asit grubuna kıyasla kontrol grubunda daha fazlaydı. Postoperatif hemoglobin düşüşü, mesane irrigasyon süresi ve toplam irrigasyon sıvısı miktarı açısından iki grup arasında istatistiksel olarak anlamlı fark bulundu. Ameliyat süresi, rezeke edilen adenomun ağırlığı, hastanede kalış süresi ve kateter çıkarma süresi açısından gruplar arasında istatistiksel olarak anlamlı fark yoktu.
Sonuç: TURP ameliyatı sonrası kullanılan intravezikal irrigasyon sıvısına eklenen traneksamik asit ile ameliyat sonrası daha az kanama ve komplikasyon ile takip süreci mümkündür.

Keywords

Traneksamik asit, transuretral prostat rezeksiyonu, irrigasyon sıvısı, postoperatif kanama

Supporting Institution

Ek Bilgiler Destekleyen Kurum

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