Epithelioid schwannoma or ossifying fibromyxoid tumour?

Year 2013, Volume: 30 Issue: 2, 193 - 195, 31.07.2013

Omer Alıcı Tuğrul Kesicioğlu

https://doi.org/10.5835/jecm.omu.30.02.023

Abstract

There is a risk of confusing epithelioid schwannoma and ossifying fibromyxoid tumors due to their similar morphological and immunohistochemical features. Epithelioid schwannoma can be described as a benign nerve sheath tumour of peripheral nerves. Ossifying fibromyxoid tumour is considered to be a intermediate malignant soft tissue tumour with the potential for recurrence and metastasis. Because the prognosis of these two tumoral entities are different from each other differential diagnosis is important. In this article, our purpose is to present a case, on what we initially considered to be epithelioid schwannoma. However, we later observed, based on the data in the literature,
that the tumour appeared to be an ossifying fibromyxoid tumour.

Keywords

Epithelioid, Fibromyxoid, Ossifying, Schwannoma, Tumour

References

• Enzinger, F.M., Weiss, S.W., Liang, C.Y., 1989. Ossifying fibromyxoid tumor of soft parts. A clinicopathological analysis of 59 cases. Am. J. Surg. Pathol. 13, 817-827.
• Folpe, A.L., Weiss, S.W., 2003. Ossifying fibromyxoid tumor of soft parts. A clinicopathologic study of 70 cases with emphasis on atypical and malignant variants. Am. J. Surg. Pathol. 27, 421-431.
• Graham, R.P., Dry, S., Li, X., Binder, S., Bahrami, A., Raimondi, S.C., Dogan, A., Chakraborty, S., Souchek, J.J., Folpe, A.L., 2011. Ossifying fibromyxoid tumor of soft parts: A clinicopathologic, proteomic, and genomic study. Am. J. Surg. Pathol. 35, 1615-1625.
• Kindblom, L.G, Meis-Kindblom, J.M., Havel, G., Busch, C., 1998. Benign epithelioid schwannoma. Am J Surg Pathol. 22, 762-70.
• Laskin, W.B., Fetsch, J.F., Lasota, J., Miettinen, M., 2005. Benign epithelioid peripheral nerve sheath tumors of the soft tissues: Clinicopatho- logic spectrum of 33 cases. Am. J. Surg. Pathol. 29, 39-51.
• Miettinen, M., Finnell, V., Fetsch, J.F.., 2008. Ossifying fibromyxoid tumor of soft parts-a clinicopathologic and immunohistochemical study of 104 cases with long-term follow-up and a critical review of the literature. Am. J. Surg. Pathol. 32, 996-1005.
• Orosz, Z., Sapi, Z., Szentirmay, Z., 1993. Unusual benign neurogenic soft tissue tumour. Epithelioid schwannoma or an ossifying fibromyxoid tumour? Pathol. Res. Pract. 189, 601-605.
• Rezanko, T., Sari, A.A., Tunakan, M., Calli, A.O., Altinboga, A.A., 2012. Epithelioid schwannoma of soft tissue: Unusual morphological variant causing a diagnostic dilemma. Ann. Diagn. Pathol. 16, 521-526.
• Saad, A.G., Mutema, G.K., Mutasim, D.F., 2005. Benign cutaneous epithelioid Schwannoma: Case report and review of the literature. Am. J. Dermatopathol. 27, 45-47.
• Weiss, S.W., Goldblum, J.R., 2008. Soft tissue tumors of intermediate malignancy of uncertain type. Weiss & Goldblum: Enzinger and Weiss’s Soft Tissue Tumors. 5th ed. Mosby Elsevier, Philadelphia, pp. 1093-1101.