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Can we use neutrophil lymphocyte ratio and platelet lymphocyte ratio as a potential biomarker for acute cholecystitis?

Year 2019, Volume: 11 Issue: 4, 404 - 408, 01.12.2019
https://doi.org/10.21601/ortadogutipdergisi.505193

Abstract

Aim: The aim of this study is to determine the effectiveness of the neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) in the diagnosis of acute cholecystitis (AC).
Material and method: 452 patients diagnosed with AC and 152 patients who admitted to the clinic with biliary colic and elective cholecystectomy have been included this study. Groups compared according to age, gender, white blood cell count (WBC), mean platelet volume (MPV), platelet distribution width (PDW), red blood cell distribution width (RDW), NLR and PLR.
Results: There was no significant difference in age between the two groups (p=0.52). Female patients were significantly higher in both control and AC groups (p=0.006). WBC, CRP, NLR, PLR values of the patients in the study group have been observed significantly higher than the control group (p<0.001). The parameter with the highest sensitivity and specificity was found as NLR.
Conclusions: NLR and PLR can be considered as a potential inflammatory biomarker for AC, due it being inexpensive and easy calculated.

References

  • Beliaev AM, Angelo N, Booth M, Bergin C. Evaluation of neutrophil-to-lymphocyte ratio as a potential biomarker for acute cholecystitis. J Surg Res 2017;209:93-101.
  • Hareen TK, Bhaskaran A, Jaswanthi A. Neutrophil to lymphocyte ratio in diagnosing acute cholecystitis: a retrospective cohort study in a tertiary rural hospital. Int J Surg 2016;4(1):372-6.
  • Joliat GR, Longchamp G, Du Pasquier C, Denys A, Demartines N, Melloul E. Delayed Cholecystectomy for Acute Cholecystitis in Elderly Patients Treated Primarily with Antibiotics or Percutaneous Drainage of the Gallbladder. J Laparoendosc Adv Surg Tech A 2018;28:1094-1099.
  • Miura F, Okamoto K, Takada T, et al. Tokyo Guidelines 2018: initial management of acute biliary infection and flowchart for acute cholangitis. J Hepatobiliary Pancreat Sci 2018;25:31-40.
  • Sayit AT, Gunbey PH, Terzi Y. Is the mean platelet volume in patients with acute cholecystitis an inflammatory marker? J Clin Diagn Res 2015;9:5-7.
  • Ertok İ, Karakayalı O, Kocasaban DU. Clinical Importance Of Neutrophil/Lymphocyte Ratio In Differential Diagnosis Of Acute Cholecystitis And Cholelithiasis. Kocaeli Med J 2016;5:6-11.
  • Bedel C. Diagnostic value of basic laboratory parameters for simple and perforated acute appendicitis. Turk J Clin Lab 2018;4:266-71.
  • Sheng F, Chen B, He M, Zhang M, Shen G. Neutrophil to lymphocyte ratio is related to electrocardiographic sign of spontaneous reperfusion in patients with ST-segment elevation myocardial infarction. Arch Med Res 2016;47:180-5.
  • Goh BK, Chok AY, Allen Jr JC, et al. Blood neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios are independent prognostic factors for surgically resected gastrointestinal stromal tumors. Surgery 2016;159:1146-56.
  • Kiriyama S, Takada T, Strasberg SM, et al. TG13 guidelines for diagnosis and severity grading of acute cholangitis (with videos). J Hepatobiliary Pancreat Sci 2013;20:24-34.
  • Temizi A, Ozdemir Y, Aslan A, Bostanci MT, Atasoy G, Caparlar MA, et al. Role of complete blood counts parameters ın dıagnosıs of acute cholecystıtıs. Acta Med Mediterr 2017;33(3):411-6.
  • Barbosa ABR, Souza LRMFd, Pereira RS, D’Ippolito G. Gallbladder wall thickening at ultrasonography: how to interpret it? Radiol Bras 2011;44:381-7.
  • Lee SK, Lee SC, Park JW, Kim S-J. The utility of the preoperative neutrophil-to-lymphocyte ratio in predicting severe cholecystitis: a retrospective cohort study. BMC Surg 2014;14:100.
  • Temiz A, Gazi E, Güngör O, et al. Platelet/lymphocyte ratio and risk of in-hospital mortality in patients with ST-elevated myocardial infarction. Med Sci Monit. 2014;20:660-5.
  • Beliaev AM, Marshall RJ, Booth M. C-reactive protein has a better discriminative power than white cell count in the diagnosis of acute cholecystitis. J Surg Res 2015;198:66-72.
  • Başol N, Çığşar G, Karaman S, Özsoy Z, Özdemir MB. The evaluation of patients with acute cholecystitis in the Emergency Department according to neutrophil-lymphocyte ratio and epidemiological factors: three-years analysis. İstanbul Bilim University Florence Nightingale Med J 2015;1:145-9

Nötrofil lenfosit oranı ve platelet lenfosit oranını akut kolesistit için potansiyel bir biyobelirteç olarak kullanabilir miyiz?

Year 2019, Volume: 11 Issue: 4, 404 - 408, 01.12.2019
https://doi.org/10.21601/ortadogutipdergisi.505193

Abstract

Amaç: Bu çalışmanın amacı, akut kolesistit (AK) tanısında nötrofil lenfosit oranı (NLO) ve trombosit lenfosit oranının (PLO) etkinliğini belirlemektir.
Gereç ve Yöntem: Çalışmaya AK tanısı alan 452 hasta ve biliyer kolik ile kliniğe başvuran ve elektif kolesistektomi yapılan 152 hasta dahil edildi. Gruplar yaş, cinsiyet, beyaz kan hücre sayısı (WBC), ortalama trombosit hacmi (MPV), trombosit dağılım genişliği (PDW), kırmızı kan hücre dağılım genişliği (RDW), NLO ve PLO’ya göre karşılaştırıldı.
Bulgular: İki grup arasında yaş açısından anlamlı fark yoktu (p = 0,52). Kadın hastalar hem kontrol hem de AK grubunda anlamlı derecede yüksekti (p = 0,006). Çalışma grubundaki hastaların WBC, CRP, NLO, PLO değerleri kontrol grubundan anlamlı olarak yüksek bulundu (p<0,001). Hassasiyeti ve özgüllüğü en yüksek olan parametre NLO olarak bulundu.
Sonuçlar: NLO ve PLO, ucuz ve hesaplamasının kolay olmasıyla AK için potansiyel bir inflamatuar biyobelirteç olarak kabul edilebilir.

References

  • Beliaev AM, Angelo N, Booth M, Bergin C. Evaluation of neutrophil-to-lymphocyte ratio as a potential biomarker for acute cholecystitis. J Surg Res 2017;209:93-101.
  • Hareen TK, Bhaskaran A, Jaswanthi A. Neutrophil to lymphocyte ratio in diagnosing acute cholecystitis: a retrospective cohort study in a tertiary rural hospital. Int J Surg 2016;4(1):372-6.
  • Joliat GR, Longchamp G, Du Pasquier C, Denys A, Demartines N, Melloul E. Delayed Cholecystectomy for Acute Cholecystitis in Elderly Patients Treated Primarily with Antibiotics or Percutaneous Drainage of the Gallbladder. J Laparoendosc Adv Surg Tech A 2018;28:1094-1099.
  • Miura F, Okamoto K, Takada T, et al. Tokyo Guidelines 2018: initial management of acute biliary infection and flowchart for acute cholangitis. J Hepatobiliary Pancreat Sci 2018;25:31-40.
  • Sayit AT, Gunbey PH, Terzi Y. Is the mean platelet volume in patients with acute cholecystitis an inflammatory marker? J Clin Diagn Res 2015;9:5-7.
  • Ertok İ, Karakayalı O, Kocasaban DU. Clinical Importance Of Neutrophil/Lymphocyte Ratio In Differential Diagnosis Of Acute Cholecystitis And Cholelithiasis. Kocaeli Med J 2016;5:6-11.
  • Bedel C. Diagnostic value of basic laboratory parameters for simple and perforated acute appendicitis. Turk J Clin Lab 2018;4:266-71.
  • Sheng F, Chen B, He M, Zhang M, Shen G. Neutrophil to lymphocyte ratio is related to electrocardiographic sign of spontaneous reperfusion in patients with ST-segment elevation myocardial infarction. Arch Med Res 2016;47:180-5.
  • Goh BK, Chok AY, Allen Jr JC, et al. Blood neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios are independent prognostic factors for surgically resected gastrointestinal stromal tumors. Surgery 2016;159:1146-56.
  • Kiriyama S, Takada T, Strasberg SM, et al. TG13 guidelines for diagnosis and severity grading of acute cholangitis (with videos). J Hepatobiliary Pancreat Sci 2013;20:24-34.
  • Temizi A, Ozdemir Y, Aslan A, Bostanci MT, Atasoy G, Caparlar MA, et al. Role of complete blood counts parameters ın dıagnosıs of acute cholecystıtıs. Acta Med Mediterr 2017;33(3):411-6.
  • Barbosa ABR, Souza LRMFd, Pereira RS, D’Ippolito G. Gallbladder wall thickening at ultrasonography: how to interpret it? Radiol Bras 2011;44:381-7.
  • Lee SK, Lee SC, Park JW, Kim S-J. The utility of the preoperative neutrophil-to-lymphocyte ratio in predicting severe cholecystitis: a retrospective cohort study. BMC Surg 2014;14:100.
  • Temiz A, Gazi E, Güngör O, et al. Platelet/lymphocyte ratio and risk of in-hospital mortality in patients with ST-elevated myocardial infarction. Med Sci Monit. 2014;20:660-5.
  • Beliaev AM, Marshall RJ, Booth M. C-reactive protein has a better discriminative power than white cell count in the diagnosis of acute cholecystitis. J Surg Res 2015;198:66-72.
  • Başol N, Çığşar G, Karaman S, Özsoy Z, Özdemir MB. The evaluation of patients with acute cholecystitis in the Emergency Department according to neutrophil-lymphocyte ratio and epidemiological factors: three-years analysis. İstanbul Bilim University Florence Nightingale Med J 2015;1:145-9
There are 16 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Original article
Authors

Cihan Bedel 0000-0002-3823-2929

Publication Date December 1, 2019
Published in Issue Year 2019 Volume: 11 Issue: 4

Cite

Vancouver Bedel C. Can we use neutrophil lymphocyte ratio and platelet lymphocyte ratio as a potential biomarker for acute cholecystitis?. omj. 2019;11(4):404-8.

e-ISSN: 2548-0251

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