SYNTHESIS OF 2-FLUOROBENZOYL THIOUREA DERIVATIVES

Year 2023, Volume: 22 Issue: 44, 417 - 424, 31.12.2023

Şule Erol Günal

https://doi.org/10.55071/ticaretfbd.1364818

Abstract

Fluorine-containing compounds play a significant role in drug development because fluorine atom has unique chemical properties due to its high electronegativity which significantly influences the properties important for drug design. In the present study, 2-fluorobenzoyl thiourea derivatives were synthesized by the reaction of 2-fluorobenzoyl isothiocyanate, which was obtained by the reaction of 2-fluorobenzoyl chloride with ammonium thiocyanate, with appropriate aniline derivatives. The structures of the benzoyl thioureas were confirmed by IR, 1H and 13C NMR spectroscopy.

Keywords

Benzoyl thioureas, fluorinated compounds, thioureas

2-FLOROBENZOİL TİYOÜRE TÜREVLERİNİN SENTEZİ

Abstract

Flor içeren bileşikler ilaç geliştirmede önemli bir rol oynar çünkü flor atomu, ilaç tasarımı için önemli olan özellikleri önemli ölçüde etkileyen yüksek elektronegatifliği nedeniyle benzersiz kimyasal özelliklere sahiptir. Bu çalışmada, 2-florobenzoil klorürün amonyum tiyosiyanat ile reaksiyonu sonucu elde edilen 2-florobenzoil izotiyosiyanatın uygun anilin türevleri ile reaksiyonu sonucu bir dizi 2-florobenzoil tiyoüre türevi sentezlendi. Benzoil tiyoüre yapıları IR, 1H ve 13C NMR spektroskopisi ile doğrulandı.

Keywords

Tiyoüreler, Benzoil tiyoüreler, florlu bileşikler

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