Kanser Hastalarında Kemoterapi İlişkili Maninin Değerlendirilmesi

Year 2024, Volume: 4 Issue: 1, 623 - 631, 25.04.2024

Fatih İnci Habibe İnci

Abstract

Amaç: Bu çalışmanın amacı kanser hastalarında kemoterapiye bağlı maniyi değerlendirmektir. Gereç ve Yöntem: Kemoterapi alan 153 kanser hastasının mani durumu, kemoterapiye başlamadan önce ve bir seans kemoterapi rejimi sonrasında Young Mani Derecelendirme Ölçeği uygulanarak karşılaştırıldı. Bulgular: Kemoterapötik ajanlara göre tedavi öncesi ve tedavi sonrası mani toplam puanları karşılaştırıldığında, Fluorourasil-Folinik Asit-Oksaliplatin Folfox (p= 0,014) ve Paklitaksel (p=0,036) kemoterapi rejimi kullananlarda tedavi sonrası mani toplam puanlarının arttığı görüldü. Folfox rejimi alan 8 (%5,2) hastada mani skoru 20 puanın üzerine çıktı. Sonuçlar: Kan-beyin bariyeri merkezi sinir sistemini birçok ilacın toksisitesinden korusa da kanser tanısı stresi ve tedavide kullanılan bazı kemoterapötikler akut konfüzyon, depresyon ve mani gibi bozukluklara neden olabilir. Çalışmamızda, literatürdeki olgu bazlı yayınlarda olduğu gibi, 5-florourasil'in kan-beyin bariyerini kolaylıkla geçebilmesi nedeniyle Folfox rejiminde toplam mani skorunda istatistiksel olarak anlamlı bir artış tespit edildi. Literatürde yayınlanmış olgu sunumlarına göre ilaçların kümülatif veya gecikmiş yan etkileri nedeniyle ikinci, üçüncü ve bazen daha sonraki seanslarda mani belirtilerinin ortaya çıkma ihtimali dikkate alınmalıdır.

Keywords

Kanser hastaları, mani, kemoterapötikler, risk

Ethical Statement

Bu çalışma için Karabük Üniversitesi Girişimsel Olmayan Etik kuruldan etik onay alındı (Onay No: 2021/726).

Supporting Institution

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Thanks

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Evaluation of Chemotherapy Related Mania in Cancer Patients

Abstract

Objective: This study aims to evaluate chemotherapy-related mania in cancer patients. Methods: The mania status of 153 cancer patients who received chemotherapy was compared by applying the Young Mania Rating Scale before starting chemotherapy and after one session of the chemotherapy regimen. Results: When the mania total scores before and after treatment were compared according to the chemotherapeutic agents, it was seen that the post-treatment mania total scores increased in those using Fluorouracil-Folinic Acid-Oxaliplatin (Folfox) (p=0.014) and paclitaxel (p=0.036) chemotherapy regimens. In 8 (5.2%) patients who received the Folfox regimen, the mild mania score exceeded 20 points. Conclusions: Although the blood-brain barrier protects the central nervous system from the toxicity of many drugs, it is known that the stress of cancer diagnosis and some chemotherapeutics used in treatment cause disorders such as acute confusion, depression, and mania. In our study, as in case-based publications in the literature, a statistically significant increase in the total mania score was found in the Folfox regimen due to 5-fluorouracil's ability to cross the blood-brain barrier easily. According to published case reports in the literature, the possibility of mania symptoms appearing in the second, third, and sometimes subsequent sessions should be taken into consideration due to cumulative or delayed side effects of the drugs.

Keywords

Cancer patients, mania, chemotherapeutics, risk

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