In
this paper the synthesis of some substituted di – 1,2,4-triazoles and it is
conversion to multi nuclear heterocyclic compounds ; described Terphthalic acid
was esterified to its ethyl ester(1)by its reaction with absolute ethanol ,
concentrated sulfuric acid , the ethyl ester (1) was treated with hydrazine
hydrate is ethanol to give the acid hydrazide (2). the hydrazide (2) then
treated with ammonium thiocyanate to give thiosemicarbazide (3) , reaction of
thiosemicarbazide (3) with hydrazine
hydrate gave 1,4-bis(
3-thiol-4-amino-1,2,4-triazole-5-yl) benzene (4). Compound (4) treatment with
three type substituted benzaldehyde gave 1,4-di hydrazones phenyl (5,6 and 7).
Cyclization hydrazones compounds (5,6,7) with phosphorous oxychloride in xylene
to gave bicyclic system 1,4-bis[1,2,4-triazole[3,4-b]-5-substituted –
1,3,4-thiadiazole] benzene (8,9 and 10)
. On the other hand some physical parameters of compounds ( 4 -10 )
under investigation such as the Mullikan charge at the active atoms, HOMO and
LUMO energy levels , hardness (η) , electronic chemical potential (µ) and global electrophilicty index (W) were theoretically calculated using ( Gaussian program ). The
antibacterial activity some of the synthesis compounds was studied. The
structures of the synthesized compounds were confirmed by physical and spectral
methods.
Birincil Dil | İngilizce |
---|---|
Konular | Mühendislik |
Bölüm | Makaleler |
Yazarlar | |
Yayımlanma Tarihi | 19 Ağustos 2018 |
Yayımlandığı Sayı | Yıl 2018Sayı: 2 |