Darbeye Bağlı Olmayan Yumuşak Doku Yaralanmalarında Moleküler Yaklaşım

Yıl 2018, Cilt: 3 Sayı: 1, 15 - 25, 30.06.2018

Başak Funda Eken Canan Sercan Defne Kaya Korkut Ulucan

Öz

önemli rol oynar. Darbeye bağlı olmayan sakatlıkların bireye özgü genetik analizlerinin bilinmesi,

sporcunun avantajlarını belirlemede ve üstesinden gelinmesi gereken dezavantajlarının saptanmasını

sağlayacaktır. Darbeye bağlı olmayan sakatlıklarda çevresel faktörlerin yanı sıra bireyin genetik

özelliklerinin etkili olduğu ifade edilmiştir. Hücrelerarası matriks proteinlerinden olan kolajen

molekülü ve biyosentezindeki bir çok genetik faktör bu konuda çalışılan en önemli genlerdir. COL1A1,

COL5A1, COL12A1, COL14A1, MMP3, TGFB1, GDF-5 ve TNC gen polimorfizmleri ise günümüzde

tendon yapısı bozuklukları ile ilişkilendirilebilen genlerin başında gelmektedir. Bu bilgiler ışığında

sakatlanma durumlarında uygun önlemler ile sakatlanma oranlarının azaltılması amaçlanmaktadır.

Bu derlemede, darbeye bağlı olmayan sakatlıkların genetik risk faktörlerinin litaratür taramaları

sunulmaktadır.

Anahtar Kelimeler

Kollajen, Tendon, Sporcu sakatlığı, Genetik

Kaynakça

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