entrCYTOTOXIC AND APOPTOTIC EFFECTS OF NOVEL SYNTHESIZED FERULIC ACID DERIVATIVES ON LEUKEMIA CELL LINESCYTOTOXIC AND APOPTOTIC EFFECTS OF NOVEL SYNTHESIZED FERULIC ACID DERIVATIVES ON LEUKEMIA CELL LINES

Yıl 2018, Cilt: 19 Sayı: 3, 628 - 636, 01.09.2018

Hakan Ünver Zerrin Cantürk

Öz

Ferulic acid (FA), or 4-hydroxy-3-methoxycinnamic acid, is a phenolic compound that can be used in many pharmacological applications, especially in the area of cancer. In this study, four new FA-quinoline esters were successfully synthesized and characterized using 1H-NMR, 13C-NMR, HR-Mass, Elemental Analysis, and FT-IR techniques. Synthesized compounds were tested on leukemia cell lines (HL-60 and K562) with WST-1 assay and Annexin V-PI assay via flow cytometry. The WST-1 assay of compounds in HL-60 and K562 leukemia cells yielded IC50 124.4 and 205.4 μM/mL, respectively. According to the results, both the cytotoxic effect and apoptotic effects of 2c increased on HL-60 cell.

Anahtar Kelimeler

Ferulic Acid, Leukemia, Apoptosis, Cytotoxicity

Kaynakça

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