Causes of elevated parathyroid hormone levels in postmenopausal women

Yıl 2017, Cilt: 3 Sayı: 3, 234 - 242, 04.11.2017

İrfan Esen Selin Akturk Esen Soner Cander Ozen Oz Gul Gokhan Ocakoglu Erdinc Erturk

https://doi.org/10.18621/eurj.278518

Cited By: 1

Öz

Objective. In this study we aimed to investigate causes of
hyperparathyroidism and related factors in postmenopausal women. Methods.
The study was conducted on 156 postmenopausal women, 43 with normal serum parathyroid
hormone (PTH) levels and 113 with elevated serum PTH levels. Serum levels of
25-OH vitamin D, calcium and phosphorus, 24-hour urine calcium, phosphorus and
calcium/creatinine ratio were compared between study groups. Also, bone mineral
density, age of menopause, educational level, occupation, clothing style,
daylight exposure time and daily dietary calcium consumption of subjects and
relationships of these parameters with parathyroid hormone levels were
investigated. Results. Causes
of elevated serum PTH level were vitamin D deficiency in 92.9% and primary
hyperparathyroidism in 4.4% of study group. Serum PTH levels were significantly
higher in housewives (p<0.001),
women with less than a high school graduates (p=0.008), and the veiled women (p=0.025).
Serum 25-OH vitamin D levels were significantly lower in the veiled covered (p=0.002) and participants with less than a high school graduate (p=0.041). Significant negative
correlation was detected between serum 25-OH vitamin D and the logarithmic
value of serum PTH levels (r= -0.188; p=0.019).
Conclusions. Vitamin D
deficiency was common in all postmenopausal women but especially in those with
lower education level and the veiled. Postmenopausal women should be screened
for vitamin D deficiency and encouraged to benefit more from sunlight. Also,
enriching foods in the markets with vitamin D may be helpful for decreasing
hyperparathyroidism in this population. 

Anahtar Kelimeler

vitamin D deficiency, postmenopausal women, Primary hyperparathyroidism, secondary hyperparathyroidism, parathyroid hormome

Kaynakça

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