Larynx
cancer (LCa), being an aggressive malignancy, is the second most commonly
diagnosed malignant type of head and neck squamous cell carcinoma worldwide.
Although there have been significant improvements in the detection and
diagnosis of LCa in the last decades, it is still one of the considerable
causes of cancer deaths and an urgent need for identification of novel
biomarkers with diagnostic and prognostic significance still remains. The
cancer stem cells (CSCs) resemble normal stem cells in terms of biological
features and are considered to play critical roles in biological aggressiveness
of tumors. Accumulating evidences have proven the existence of CSCs in various
tumors including LCa and they are considered as driving force for tumor
relapse, metastasis, and chemo-radioresistance. Comprehensive identification
and characterization of the CSCs is of paramount importance for their further
characterization to develop more effective and targeted therapeutic strategies
against cancer. Here, we reviewed and summarized the most current literature to
provide an insight into the functions and roles of current CSCs biomarkers in
human LCa. We believe that this review will contribute to the knowledge of
scientists especially working with LCa CSCs and will help understanding the
significance of CSCs biomarkers implicated in LCa pathogenesis.
Konular | Sağlık Kurumları Yönetimi |
---|---|
Bölüm | Reviews |
Yazarlar | |
Yayımlanma Tarihi | 4 Kasım 2017 |
Gönderilme Tarihi | 6 Mayıs 2017 |
Kabul Tarihi | 31 Mayıs 2017 |
Yayımlandığı Sayı | Yıl 2017 Cilt: 3 Sayı: 3 |