Inflammation
is the defensive mechanism against physical or chemical or thermal or infectious agents.
Acute inflammation is a protective mechanism against any noxious stimuli by
various mediators such as cytokines, chemokines, enzymes, growth factors by
inflammatory cells. If the inflammation is aggrevated chronically, smouldering
inflammation results in release of inflammatory mediators such as cytokines,
chemokines, growth factors, proteolytic enzymes, from innate and adaptive
immune cells results in tumor initiation, tumor promotion and tumor
progression. Cytokines are intercellular molecular messengers between immune
cells and cancer cells, synthesized from immune cells and stromal cells
activate transcription factors bring about tumor progression by cell
proliferation, cell survival, angiogenesis, genomic instability, epithelial to
mesenchymal transition, invasion and metastasis. This article briefs about
the role of IL-1, TNF-α, IL-6, IL-8, IL-10, TGF-β, and IL-17 cytokines in
progression of cancer.
Birincil Dil | İngilizce |
---|---|
Konular | Sağlık Kurumları Yönetimi |
Bölüm | Reviews |
Yazarlar | |
Yayımlanma Tarihi | 4 Temmuz 2018 |
Gönderilme Tarihi | 28 Ekim 2017 |
Kabul Tarihi | 19 Şubat 2018 |
Yayımlandığı Sayı | Yıl 2018 Cilt: 4 Sayı: 3 |