Phormidium Türlerinin Tıbbi Özelliklerinin Araştırılması

Yıl 2018, Cilt: 7 Sayı: 1, 101 - 115, 15.04.2018

Tuğba Demiriz Yücer Köksal Pabuçcu

Öz

Phormidium türleri, Siyanobakteriler içindeki önemli gruplardan biridir. Siyanobakteriler içermiş oldukları yüksek düzeyde protein, vitamin, mineral, yağ asitleri ve pigmentler nedeniyle son zamanlarda üzerinde en fazla çalışılan organizma gruplarından biri olmuştur. Bu organizmalar, ilaç hammaddesi olabilen temel bileşenleri içerdikleri için, medikal çalışmalarda önemli konumdadır. Toksisitesi düşük olan türlerin önemi daha da fazladır. Bu çalışmada, Phormidium türlerinin antibiyotik, antiviral, antikanser, antifungal, antibakteriyal, antioksidan özellikleri ve bazı farmakolojik etkileri ortaya konulmuş ve onların tıbbi özellikleri konusunda yapılan araştırmalar tartışılmıştır.

Anahtar Kelimeler

Phormidium, Cyanobacteria, antimikrobiyal, antioksidan, antikanser, antifungal

Kaynakça

• Abed, R.M.M., Kohls, K., Schoon, R. Scherf, A.K., Schacht, M., Palinska, K.A., Al Hassani, H., Hamza, W., Rullkötter, J., Golubic, S., 2008.‘Lipid biomarkers, pigments and cyanobacterial diversity of microbial mats across intertidal flats of the arid coast oft he Arabian Gulf (Abu Dhabi, UAE)’, FEMS Microbiol Ecol, 65: 449-462.
• Abo-State, M. A. M., Shanab, S. M. M., Hamdy E. A. Ali, H. E. A., Abdullah, M. A., 2015. ‘Screening of Antimicrobial Activity of Selected Egyptian Cyanobacterial Species’, Journal of Ecology of Health & Environment, 3 (1): 7-13.
• Amaro, H., Guedes, A., Malcata, F.,2011. ‘Antimicrobial activities of microalgae: an invited review. Science against Microbial Pathogens’, Communicating Current Research and Technological Advances, 1272–1280.
• Asadi, A., Khavari-Nejad, R., Soltani, N., Najafi, F., Molaie-Rad, A., 2011. ‘Physiological and antimicrobial characterizations of some cyanobacteria isolated from the rice fields in Iran, Journal of Agricultural Technology, 7(3): 649-663.
• Bryant, D.A., 1994. ‘The Molecular Biology of Cyanobacteria’, Kluwer Academic Publishers, Dordrecht.
• Chatterjee, D., Bhattacharjee, P., 2014. ‘Supercritical carbon dioxide extraction of antioxidant rich fraction from Phormidium valderianum: Optimization of experimental process parameters’, Algal Research, 3: 49–54.
• Davis, T. A., Volesky, B., Mucci, A., 2003. ‘A review of the biochemistry of heavy metal biosorption by brown algae’, Water Research, 37: 4311-4330.
• Demiriz, T., Çökmüş, C., Pabuçcu, K., 2011. ‘Antimicrobial Activity of Some Algal Species Belonging to Cyanobacteria and Chlorophyta’, Asian Journal of Chemistry, 23 (3): 1384-1386.
• Dzhambazov, B., Teneva, I., Mladenov, R., Popov, N., 2006. ‘In vitro cytotoxicity and anticancer properties of two Phormidium molle strains (Cyanoprokaryota)’, Trav. Sci. Univ. Plovdiv, Plantarum, 39 (6): 3-16.
• El Semary, N. A., Fouda, M., 2015. ‘Anticancer activity of Cyanothece sp. strain extracts from Egypt: First record’, Asian Pacific Journal of Tropical Biomedicine, 5(12): 992–995.
• Elkomy, R., Ibraheem, I.B.M., Shreadah, M., Mohammed, R., Ismael, A., 2015. ‘Antimicrobial Activity of Three Microalgae Isolated from Mediterranean Sea Coast, Egypt’, Journal of Pure and Applied Microbiology, 9 (4): 2751-2758.Fogg, G.E., Stewart, W.D.P., Fay, P., Walsby, A.E., 1973. ‘The Blue-Green Algae’, Academic Press, London.
• Gargouri, M, Magne, C, El Feki, A, 2016, ‘Hyperglycemia, oxidative stress, liver damage and dysfunction in alloxan-induced diabetic rat are prevented by Spirulina supplementation’ Nutrition Research, Volume 36, Issue 11, November 2016, Pages 1255-1268.
• Gustafson, K. R., Cardellina, J. H., Fuller, R. W., Weislow, O. S., Kiser, R. F., Snader, K. M., Patterson, G. M. L., Boyd, M. R., 1989. ‘AIDS-Antiviral Sulfolipids From Cyanobacteria (Blue- Green Algae), Journal of the National Cancer Institute, 81 (16): 1254-1258.
• Guiry, M.D, Guiry, G.M., 2018. ‘AlgaeBase’. World-wide electronic publication, National University of Ireland, Galway. http://www.algaebase.org; searched on 7 February.
• Humm, H.J., Wick, S.R., 1980. ‘Introduction and guide to the Marine Bluegreen Algae’, John Wiley and Sons, Brisbane.
• Herrero, J., Valencia, A., Dopazo, J., 2001. ‘A hierarchical unsupervised growing neural network for clustering gene expression patterns’, Bioinformatics, 17: 126–138.
• Jin, E., Polle, J.E.W., Lee, H.K., Hyun, S.M., Chang, M., 2003. ‘Xanthophylls in microalgae: From biosynthesis to biotechnological mass production and application’, Journal of Microbiology and Biotechnology, 13: 165-174.
• Kammennaya N.A., Anton F.P., 2011. ‘Characterization of cyanate metabolism in marine Synechococcus and Prochlorococcus spp.’, Applied and Environmental Microbiology, 77 (1): 291-301.
• Koksharova, O.A, Wolk, C.P., 2002. ‘Genetic tools for cyanobacteria’, Appl Microbiol Biotechnol, 58: 123-137.
• Lopes, V.R., Schmidtke, M., Fernandes, M. H., Martins, R., Vasconcelos, V., 2011. ‘Cytotoxicity in L929 fibroblasts and inhibition of herpes simplex virus type 1 Kupka by estuarine cyanobacteria extracts’, Toxicology in Vitro, 25 :944–950.
• Lyra, C., Suomalainen, S., Gugger, M., Vezie, C., Sundman, P., Paulin, L., Sivonen, K., 2001. ‘Molecular Characterization of Planktic Cyanobacteria of Anabaena, Aphanizomenon, Microcystis and Planktothrix genera’, Int J Syst Evol Microbiol, 51: 513-526.
• Mackay, D., Stiver, W., Tebeau, P.A., 1983.‘Testing of crude oils and petroleum products for environmental purposes’, Oil Spill Conference, American Petroleum Institute, Washington 31.
• Madhumathi, V., Deepa, P., Jeyachandran, S., Manoharan, C., Vijayakumar, S., 2011. ‘Antimicrobial Activity of Cyanobacteria Isolated from Freshwater Lake’, International Journal of Microbiological Research, 2 (3): 213-216.
• Mian, P., Heilmann, J., Bürgi & O. Sticher, H.R., 2003. ‘Biological Screening of Terrestrial and Freshwater Cyanobacteria for Antimicrobial Activity, Brine Shrimp Lethality, and Cytotoxicity’, Pharmaceutical Biology, 41(4): 243-247.
• Mtolera, M. S. P., Semesi, A. K., 1996. ‘Antimicrobial activity of extraxts from six green algae from Tanzania’, Botanical Research, 211–217.
• Neilan B.A, Jacobs D., Goodman A.E., 1995. ‘Genetic diversity and phylogeny of toxic cyanobacteria determined by dna polymorphisms within the phycocyanin locus’, Applied And Environmental Microbıology, 61 (11): 3875–3883.
• Niu, J.F., Wang, G.C., Lin X.Z., Zhou, B.C., 2007. ‘Large-scale recovery of C-phycocyanin from Spirulina platensis using expanded bed adsorption chromatography’, Journal of Chromatography B, 850: 267-276.Olaizola, M., 2003. ‘Commercial development of microalgal biotechnology: from the test tube to the marketplace’, Biomolecular Engineering, 20: 459-466.
• Pawar, S.T., Puranik, P. R., 2008. ‘Screening of terrestrial and freshwater halotolerant cyanobacteria for antifungal activities’, World J Microbiol Biotechnol, 24: 1019–1025.
• Patel, A., Mishra, S., Ghosh, P.K., 2006. ‘Antioxidant potential of C-phycocyanin isolated from cyanobacterial species Lyngbya, Phormidium and Spirulina spp.’, Indian Journal of Biochemistry &Biophysics, 43: 25-31.
• Ravi Kumar, S., Ramanathan, G., Subhakaran, M., Jacob Inbaneson, S., 2009. ‘Antimicrobial compounds from marine halophytes for silkworm disease treatment’, International Journal of Medicine and Medical Sciences, 1(5): 184-191.
• Rodrigues, D. B., Menezes, C. R., Mercadante, A. Z., Jacob-Lopes, E., Zepka, L. Q., 2015. ‘Bioactive pigments from microalgae Phormidium autumnale’, Food Research International, 77: 273-279.
• Rodriguez-Meizoso, I., Jaime, L., Santoyo, S., Cifuentes, A., Garcia-Blairsy Reina, G., Senorans, F. J., Ibanez, E., 2008. ‘Pressurized Fluid Extraction of Bioactive Compounds from Phormidium Species’, J. Agric. Food Chem., 56: 3517–3523.
• Sakthivel, K., Kathiresan, K., 2012. ‘Antimicrobial activities of marine cyanobacteria isolated from mangrove environment of south east coast of India’, Journal of Natural Products, 5: 147-156.
• Senthil Kumar, N.S., Sivasubramanian, V., Mukund, S., 2013. ‘Antimicrobial and Antifungal activity of extracts of Phormidium fragile Gomont.’, J. Algal Biomass Utln., 4 (3): 66–71.
• Shanab, S. M. M., Mostafa, S. S. M., Shalaby, E. A., Mahmoud, G. I., 2012. ‘Aqueous extracts of microalgae exhibit antioxidant and anticancer activities’, Asian Pac J Trop Biomed, 2(8): 608-615.
• Soni, B., Trivedi, U., Madamwar, D., 2008. ‘A novel method of single step hydrophobic interaction chromatography for the purification of phycocyanin from Phormidium fragile and its characterization for antioxidant property’, Bioresource Technology, 99: 188–194.
• Srivastava, A., Tiwari, R., Srivastava, V., Singh, T. B., Asthana, R. K., 2012. ‘Fresh Water Cyanobacteria Geitlerinema sp. CCC728 and Arthrospira sp. CCC729 as an Anticancer Drug Resource’, Fresh Water Cyanobacteria as Anticancer Drug Resource, 10: 1-18.
• Stainer, R.Y., Cohen-Bazire, C.G.,1977. ‘Phototrophic Prokaryotes: The Cyanobacteria’, Ann Rev Microbiol, 31: 225-274.
• Stewart, W.D.P., 1973. ‘Nitrogen fixation by photosynthetic microorganisms’, Ann. Rev. Microbiol., 27: 283-316.Sundaramanickam, A., Palanivel, S., Shekhar, S., Kumaresan, S., Balasubramanian, T., 2015. ‘In vitro evaluation of Antimicrobial activity of some selected Cyanobacterial extracts against human pathogens’, IJAPBC, 4 (1): 36-43.
• Walsby A.E., 1987. ‘Mechanisms of buoyancy regulation by planktonic cyanobacteria with gas vesicles, The Cyanobacteria, Elsevier, 377-414.
• Walsby A.E., Yacobi Y.Z., Zohary T., 2003. ‘Annual changes in the mixed depth ve critical depth for photosynthesis by aphanizomenon ovalisporum that allow growth of the cyanobacterium in lake kinneret’, Israel Journal of Plankton, 25 (6): 608-613.
• Warr, S.R.C., Redd, R.H., Stewart, W.D.P., 1984. ‘Physiological responses of Nodularia harveyana to osmotic stress’, Marine Biology, 79: 21-26.
• Whitton, B.A., Potts, M., 2000. ‘Introduction to Cyanobacteria’, The Ecology of Cyanobacteria, Their Diversity in Time and Space, Kluwer Academic, Hingham, 132.