Dyslipidemia Pattern in Rheumatoid Arthritis Patients with Correlation of Disease Activity

Yıl 2017, Cilt: 7 Sayı: 2, 132 - 137, 29.05.2017

Prakash Joshi Prakhar Kabra Rajesh Kumar Jha

https://doi.org/10.16899/gopctd.316827

Öz

Aim: Rheumatoid arthritis (RA) is a multi-factorial disease which affects the immune system and ultimately various tissues in the body that typically affects middle-aged individuals. Our objectives were to evaluate prevalence of dyslipidemias and its pattern in RA patients in Central India and correlate dyslipidemia with disease activity.

Material and methods: This cross-sectional study was conducted on RA patients at Sri Aurobindo Institute of Medical Sciences and Post Graduate Institute, Indore (M.P.) between January 2014 and December 2015. Lipid profiles were determined following 12-hour overnight fasting, and the association of lipid profiles with and disease activity was determined. Results: The maximum number of cases presented in the age group was 41-50(36%). Disease is more prevalent in female population. Maximum number of pateints (34 patients) had duration of illness ranged between 1 to 10 years. Most of the patients presented with high disease activity (90%). Total cholesterol levels were significantly higher in female cases as compared to controls. Similar to total cholesterol, Low density lipoprotein (LDL) cholesterol was significantly higher in female cases as compared to controls. There was no significant difference of High density lipoprotein(HDL), Very low density lipoprotein(VLDL) and Triglyceride(TG) between cases and controls. Mean lipid profile values were similar in male cases and controls. Positive correlation of Disease activity score (DAS)-28 Erythrocyte sedimentation rate (ESR) was observed with total cholesterol and LDL levels in female patients only. No correlation of HDL, LDL and triglyceride were observed with DAS- 28 and ESR in both male and female patients. Conclusions: Lipid profiles were similar in both treatment naive and on treatment patients. No significant difference in mean lipid profile values expect HDL was observed in two groups created on the basis of RA factor. A lipid profile value has no positive or negative correlation with duration of illness. aim: Rheumatoid arthritis (RA) is a multi-factorial disease which affects the immune system and ultimately various tissues in the body that typically affects middle-aged individuals. Our objectives were to evaluate prevalence of dyslipidemias and its pattern in RA patients in Central India and correlate dyslipidemia with disease activity.Material and methods: This cross-sectional study was conducted on RA patients at Sri Aurobindo Institute of Medical Sciences and Post Graduate Institute, Indore (M.P.) between January 2014 and December 2015. Lipid profiles were determined following 12-hour overnight fasting, and the association of lipid profiles with and disease activity was determined.

Results: The maximum number of cases presented in the age group was 41-50(36%). Disease is more prevalent in female population. Maximum number of pateints (34 patients) had duration of illness ranged between 1 to 10 years. Most of the patients presented with high disease activity (90%). Total cholesterol levels were significantly higher in female cases as compared to controls. Similar to total cholesterol, Low density lipoprotein (LDL) cholesterol was significantly higher in female cases as compared to controls. There was no significant difference of High density lipoprotein(HDL), Very low density lipoprotein(VLDL) and Triglyceride(TG) between cases and controls. Mean lipid profile values were similar in male cases and controls. Positive correlation of Disease activity score (DAS)-28 Erythrocyte sedimentation rate (ESR) was observed with total cholesterol and LDL levels in female patients only. No correlation of HDL, LDL and triglyceride were observed with DAS- 28 and ESR in both male and female patients.

Conclusions: Lipid profiles were similar in both treatment naive and on treatment patients. No significant difference in mean lipid profile values expect HDL was observed in two groups created on the basis of RA factor. A lipid profile value has no positive or negative correlation with duration of illness.

Anahtar Kelimeler

Dyslipidemia, Rheumatoid Arthritis, Disease Severity

Romatoid Artritli Hastalarda Dislipidemi Paterni ve Hastalık Aktivitesi ile İlişkisi

Öz

Amaç: Romatoid artrit (RA), bağışıklık sistemini ve nihayetinde orta yaşlı bireyleri etkileyen vücudun çeşitli dokularını etkileyen çok faktörlü bir hastalıktır. Orta Hindistan'daki RA hastalarında dislipidemi prevalansını ve paternini değerlendirmek ve dislipidemi ile hastalık aktivitesini ilişkilendirmek amaçlandı.

Materyal ve Metod: Kesitsel tipteki bu çalışma, Ocak 2014 ile Aralık 2015 tarihleri arasında, Indore'da (MP) Sri Aurobindo Tıp Bilimleri Enstitüsü ve Yüksek Lisans Enstitüsü'nde RA hastalarında gerçekleştirildi. Lipid profilleri 12 saatlik bir açlık sonrası belirlendi ve lipit profilleri ile hastalık aktivitesi ilişkisi saptanmıştır.

Bulgular: Yaş gruplarında sunulan olguların maksimum sayısı 41-50 (% 36) idi. Hastalık kadın nüfusta daha yaygındır. Maksimum hasta sayısı (34 hasta) hastalık süresi 1 ila 10 yıl arasında değişiyordu. Hastaların çoğunda hastalık aktivitesi yüksekti (% 90). Toplam kolesterol düzeyi, kadın olgularda kontrol grubuna göre anlamlı derecede yüksekti. Toplam kolestrol benzer şekilde düşük yoğunluklu lipoprotein (LDL) kolestrol kadınlarda kontrollerden daha yüksekti. Olgular ve kontroller arasında Yüksek dansiteli lipoprotein (HDL), Çok düşük dansiteli lipoprotein (VLDL) ve Trigliserid (TG) arasında anlamlı fark yoktu. Erkek olgularda ve kontrollerde ortalama lipid profili değerleri benzerdi. Hastalık aktivite skorunun (DAS)-28 ve eritrosit sedimentasyon hızı (ESR) yalnızca kadın hastalarda total kolesterol ve LDL düzeyleri ile pozitif korelasyonu gözlendi. DAS-28 ve ESR hem kadın hem de erkek hastalarda HDL, LDL ve trigliserid arasında bir korelasyon gözlenmedi.

Sonuç: Lipid profilleri hem naif hem de tedavi edilen hastalarda benzerdi. Ortalama lipid profili değerlerinde anlamlı fark yok RAF faktörüne dayalı olarak oluşturulan iki grupta HDL'nin beklendiği beklendi. Bir lipid profili değeri hastalığın süresi ile pozitif veya negatif korelasyon göstermez.

Anahtar Kelimeler

Dislipidemi, Romatoid Artrit, Hastalık Şiddeti

Kaynakça

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