Obezite Üzerine Etkili Yeni Bir Hormon: İrisin

Yıl 2017, Cilt: 6 Sayı: 3, 176 - 183, 30.09.2017

Nazlı Nur Aslan Hülya Yardımcı

Öz

Günümüzde miyokin olarak tanımlanan irisin, fibronektin tip III domain 5 proteininin proteolitik ürünüdür ve egzersiz yoluyla beyaz adipoz doku hücrelerini kahverengi adipoz doku hücrelerine çevirir. Böylece enerji harcamasını artırır ve ısı üretimine neden olur. Yapılan ilk çalışmalarda irisin, obezite ve Tip 2 diyabet gibi hastalıkların tedavisi için bir alternatif olarak düşünülmüştür. Ancak daha sonra yapılan çalışmalarda, özel hasta gruplarında farklı egzersiz tipleri uygulandıktan sonra irisinin çelişkili sonuçlara neden olduğu gözlemlenmiştir. Bu nedenle irisinin metabolik etkileri ve obezite üzerindeki rolüne ilişkin tartışmalar hala devam etmektedir. Özellikle irisinin obezitenin rolüne ilişkin etkileri ile ilgili çalışmalar çok az sayıdadır. Bu derlemede irisinin yapısı, sentezi ve biyokimyasal etkilerinden bahsedilmiş, irisinin obezite, cinsiyet ve egzersiz üzerine etkileriyle ilgili çalışmalar özetlenmiştir.

Anahtar Kelimeler

Obezite, İrisin, FNDC5, Egzersiz

Kaynakça

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