Ruxolitinib ve etki mekanizmaları

Yıl 2016, Cilt: 2 Sayı: 2, 153 - 157, 01.06.2016

Bakiye Göker Bağca Çığır Biray Avcı

Öz

Ruxolitinib JAK1 ve JAK2 tirozin kinazlarının inhibitörüdür. Jakafi adıyla piyasaya sürülen ruxolitinib, miyelofibroz tedavisinde onaylanan ilk kimyasalajan olarak 2011 yılından beri kullanılmaktadır. Miyeloproliferatif neoplazmlar (MPN) Philadelphia kromozom (Ph) pozitif ve negatif hastalıkları içerir.2001 yılında imatinib tirozin kinazının geliştirilmesinden bu yana Ph+ kronik miyeloid lösemi tedavisinde tirozin kinaz inhibitörlerine odaklanılmıştır.Direnç gelişimine bağlı olarak yeni nesil tirozin kinaz inhibitörleri geliştirilmiş ve kullanılmıştır. Bunun tersine Ph- MPN’lerde hedefli tedavi dahaaz anlaşılmış güncel bir konudur. Ph-MPN’ler genellikle JAK-STAT yolağının mutasyonlarından kaynaklanır. Bu derlemede hem Ph+ hem de Ph-MPN’lerde en güncel tirozin kinaz inhibitörü olan ruxolitinib ile oluşturulabilecek hedefli tedavi seçenekleri incelenmiştir.

Anahtar Kelimeler

mekanizmalar, miyeloproliferatif neoplazmlar, ruxolitinib

Kaynakça

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