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Treatment approach in our hypertriglyceridemia induced acute pancreatitis patients

Yıl 2015, Cilt: 1 Sayı: 3, 129 - 133, 07.12.2015

Utku Erdem Soyaltın Tuba Demirci Yıldırım Emin Taşkıran Andaç Develi Ferhat Ekinci Bilgin Demir Harun Akar

Öz

Objectives: We aimed to research the superiority of insulin infusion and triglyceride apheresis for the treatment of hypertriglyceridemia-induced acute pancreatitis (HIAP).

Patients and methods: In this retrospective, single-center cohort study, demographic data, clinical and biochemical parameters of HIAP were retrieved from the medical record database. The clinical data of 12 patients with HIAP were retrospectively analyzed.

Results: The indication and timing of intervention and which treatment modality in HIAP is most efficacious remains unclear. We want to highlight our experience that seems to be equal therapeutic potential of both options.

Conclusion: In treatment of HIAP, comorbidities should be taken into consideration and treatment should be personalized. More studies are needed to help define the best treatment option for HIAP.

Anahtar Kelimeler

-

Kaynakça

  • Fortson MR, Freedman SN, Webster PD. Clinical assessment of hyperlipidemic pancreatitis. Am J Gastroenterol 1995;90:2134-9.
  • Toskes PP. Hyperlipidemic pancreatitis. Gastroenterol Clin North Am 1990;19:783-91.
  • Chang CC, Hsieh YY, Tsai HD, Yang TC, Yeh LS, Hsu TY. Acute pancreatitis in pregnancy. Zhonghua Yi Xue Za Zhi (Taipei) 1998;61:85-92.
  • Fredrickson DS. An international classification of hyperlipidemias and hyperlipoproteinemias. Ann Intern Med 1971;75:471-2.
  • Yadav D, Pitchumoni CS. Issues in hyperlipidemic pancreatitis. J Clin Gastroenterol 2003;36:54-62.
  • Havel RJ. Approach to the patient with hyperlipidemia. Med Clin North Am 1982;66:319-33.
  • Rivellese AA, De Natale C, Di Marino L, Patti L, Iovine C, Coppola S, et al. Exogenous and endogenous postprandial lipid abnormalities in type 2 diabetic patients with optimal blood glucose control and optimal fasting triglyceride levels. J Clin Endocrinol Metab 2004;89:2153-9.
  • Alagözlü H, Cindoruk M, Karakan T, Unal S. Heparin and insulin in the treatment of hypertriglyceridemia- induced severe acute pancreatitis. Dig Dis Sci 2006;51:931-3.
  • Jabbar MA, Zuhri-Yafi MI, Larrea J. Insulin therapy for a non-diabetic patient with severe hypertriglyceridemia. J Am Coll Nutr 1998;17:458-61.
  • Mikhail N, Trivedi K, Page C, Wali S, Cope D. Treatment of severe hypertriglyceridemia in nondiabetic patients with insulin. Am J Emerg Med 2005;23:415-7.
  • Betteridge DJ, Bakowski M, Taylor KG, Reckless JP, de Silva SR, Galton DJ. Treatment of severe diabetic hypertriglyceridaemia by plasma exchange. Lancet 1978;1:1368.
  • Bae JH, Baek SH, Choi HS, Cho KR, Lee HL, Lee OY, et al. Acute pancreatitis due to hypertriglyceridemia: report of 2 cases. Korean J Gastroenterol 2005;46:475-80.
  • Yeh JH, Chen JH, Chiu HC. Plasmapheresis
  • for hyperlipidemic pancreatitis. J Clin Apher 2003;18:181-5.
  • Iskandar SB, Olive KE. Plasmapheresis as an adjuvant therapy for hypertriglyceridemia-induced pancreatitis. Am J Med Sci 2004;328:290-4.
  • Leese T, Holliday M, Watkins M, Thomas WM,
  • Neoptolemos JP, Hall C, et al. A multicentre controlled clinical trial of high-volume fresh frozen plasma therapy in prognostically severe acute pancreatitis. Ann R Coll Surg Engl 1991;73:207-14.
  • Chen JH, Yeh JH, Lai HW, Liao CS. Therapeutic plasma exchange in patients with hyperlipidemic pancreatitis. World J Gastroenterol 2004;10:2272-4.
  • Syed H, Bilusic M, Rhondla C, Tavaria A. Plasmapheresis in the treatment of hypertriglyceridemia-induced pancreatitis: A community hospital's experience. J Clin Apher 2010;25:229-34.
  • Chen JH, Yeh JH, Lai HW, Liao CS. Therapeutic plasma exchange in patients with hyperlipidemic pancreatitis. World J Gastroenterol 2004;10:2272-4.

Hipertrigliseridemi ilişkili akut pankreatitli hastalarda tedavi yaklışımımız

Yıl 2015, Cilt: 1 Sayı: 3, 129 - 133, 07.12.2015

Utku Erdem Soyaltın Tuba Demirci Yıldırım Emin Taşkıran Andaç Develi Ferhat Ekinci Bilgin Demir Harun Akar

Öz

Amaç: Çalışmamızda hipertrigliseridemi ilişkili akut pankreatit (HİAP) tedavisinde insülin infüzyonu ve trigliserid aferezinin, birbirine üstünlüğünü araştırmayı amaçladık.Hastalar ve yöntemler: Retrospektif, tek merkezli, kohort olan bu çalışmada, HİAP’nin klinik ve biyokimyasal parametreleri tıbbi kayıt veri bankasından elde edildi. On iki HİAP’li hastanın klinik verileri retrospektif olarak incelendi.Bulgular: HİAP’de tedavi endikasyonu, zamanlaması ve hangi tedavi yönteminin en etkili olduğu halen net değildir. Her iki tedavi seçeneğinin eşit iyileştirici potansiyeli olduğuna dair deneyimlerimizi vurgulamak istiyoruz. Sonuç: HİAP tedavisinde komorbit hastalıklar dikkate alınmalı ve tedavi bireyselleştirilmelidir. HİAP için en iyi tedavi seçeneğini tanımlamak için daha fazla çalışmaya ihtiyaç duyulmaktadır

Anahtar Kelimeler

Akut pankreatit Baltazar skoru hipertriglisidemi trigliserid aferezi

Kaynakça

  • Fortson MR, Freedman SN, Webster PD. Clinical assessment of hyperlipidemic pancreatitis. Am J Gastroenterol 1995;90:2134-9.
  • Toskes PP. Hyperlipidemic pancreatitis. Gastroenterol Clin North Am 1990;19:783-91.
  • Chang CC, Hsieh YY, Tsai HD, Yang TC, Yeh LS, Hsu TY. Acute pancreatitis in pregnancy. Zhonghua Yi Xue Za Zhi (Taipei) 1998;61:85-92.
  • Fredrickson DS. An international classification of hyperlipidemias and hyperlipoproteinemias. Ann Intern Med 1971;75:471-2.
  • Yadav D, Pitchumoni CS. Issues in hyperlipidemic pancreatitis. J Clin Gastroenterol 2003;36:54-62.
  • Havel RJ. Approach to the patient with hyperlipidemia. Med Clin North Am 1982;66:319-33.
  • Rivellese AA, De Natale C, Di Marino L, Patti L, Iovine C, Coppola S, et al. Exogenous and endogenous postprandial lipid abnormalities in type 2 diabetic patients with optimal blood glucose control and optimal fasting triglyceride levels. J Clin Endocrinol Metab 2004;89:2153-9.
  • Alagözlü H, Cindoruk M, Karakan T, Unal S. Heparin and insulin in the treatment of hypertriglyceridemia- induced severe acute pancreatitis. Dig Dis Sci 2006;51:931-3.
  • Jabbar MA, Zuhri-Yafi MI, Larrea J. Insulin therapy for a non-diabetic patient with severe hypertriglyceridemia. J Am Coll Nutr 1998;17:458-61.
  • Mikhail N, Trivedi K, Page C, Wali S, Cope D. Treatment of severe hypertriglyceridemia in nondiabetic patients with insulin. Am J Emerg Med 2005;23:415-7.
  • Betteridge DJ, Bakowski M, Taylor KG, Reckless JP, de Silva SR, Galton DJ. Treatment of severe diabetic hypertriglyceridaemia by plasma exchange. Lancet 1978;1:1368.
  • Bae JH, Baek SH, Choi HS, Cho KR, Lee HL, Lee OY, et al. Acute pancreatitis due to hypertriglyceridemia: report of 2 cases. Korean J Gastroenterol 2005;46:475-80.
  • Yeh JH, Chen JH, Chiu HC. Plasmapheresis
  • for hyperlipidemic pancreatitis. J Clin Apher 2003;18:181-5.
  • Iskandar SB, Olive KE. Plasmapheresis as an adjuvant therapy for hypertriglyceridemia-induced pancreatitis. Am J Med Sci 2004;328:290-4.
  • Leese T, Holliday M, Watkins M, Thomas WM,
  • Neoptolemos JP, Hall C, et al. A multicentre controlled clinical trial of high-volume fresh frozen plasma therapy in prognostically severe acute pancreatitis. Ann R Coll Surg Engl 1991;73:207-14.
  • Chen JH, Yeh JH, Lai HW, Liao CS. Therapeutic plasma exchange in patients with hyperlipidemic pancreatitis. World J Gastroenterol 2004;10:2272-4.
  • Syed H, Bilusic M, Rhondla C, Tavaria A. Plasmapheresis in the treatment of hypertriglyceridemia-induced pancreatitis: A community hospital's experience. J Clin Apher 2010;25:229-34.
  • Chen JH, Yeh JH, Lai HW, Liao CS. Therapeutic plasma exchange in patients with hyperlipidemic pancreatitis. World J Gastroenterol 2004;10:2272-4.
Toplam 20 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Bölüm Makaleler
Yazarlar

Utku Erdem Soyaltın Bu kişi benim

Tuba Demirci Yıldırım

Emin Taşkıran Bu kişi benim

Andaç Develi Bu kişi benim

Ferhat Ekinci Bu kişi benim

Bilgin Demir Bu kişi benim

Harun Akar Bu kişi benim

Yayımlanma Tarihi 7 Aralık 2015
Yayımlandığı Sayı Yıl 2015 Cilt: 1 Sayı: 3

Kaynak Göster

APA Soyaltın, U. E., Demirci Yıldırım, T., Taşkıran, E., Develi, A., vd. (2015). Treatment approach in our hypertriglyceridemia induced acute pancreatitis patients. İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi, 1(3), 129-133. https://doi.org/10.5606/fng.btd.2015.024
AMA Soyaltın UE, Demirci Yıldırım T, Taşkıran E, Develi A, Ekinci F, Demir B, Akar H. Treatment approach in our hypertriglyceridemia induced acute pancreatitis patients. İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi. Aralık 2015;1(3):129-133. doi:10.5606/fng.btd.2015.024
Chicago Soyaltın, Utku Erdem, Tuba Demirci Yıldırım, Emin Taşkıran, Andaç Develi, Ferhat Ekinci, Bilgin Demir, ve Harun Akar. “Treatment Approach in Our Hypertriglyceridemia Induced Acute Pancreatitis Patients”. İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi 1, sy. 3 (Aralık 2015): 129-33. https://doi.org/10.5606/fng.btd.2015.024.
EndNote Soyaltın UE, Demirci Yıldırım T, Taşkıran E, Develi A, Ekinci F, Demir B, Akar H (01 Aralık 2015) Treatment approach in our hypertriglyceridemia induced acute pancreatitis patients. İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi 1 3 129–133.
IEEE U. E. Soyaltın, “Treatment approach in our hypertriglyceridemia induced acute pancreatitis patients”, İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi, c. 1, sy. 3, ss. 129–133, 2015, doi: 10.5606/fng.btd.2015.024.
ISNAD Soyaltın, Utku Erdem vd. “Treatment Approach in Our Hypertriglyceridemia Induced Acute Pancreatitis Patients”. İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi 1/3 (Aralık 2015), 129-133. https://doi.org/10.5606/fng.btd.2015.024.
JAMA Soyaltın UE, Demirci Yıldırım T, Taşkıran E, Develi A, Ekinci F, Demir B, Akar H. Treatment approach in our hypertriglyceridemia induced acute pancreatitis patients. İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi. 2015;1:129–133.
MLA Soyaltın, Utku Erdem vd. “Treatment Approach in Our Hypertriglyceridemia Induced Acute Pancreatitis Patients”. İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi, c. 1, sy. 3, 2015, ss. 129-33, doi:10.5606/fng.btd.2015.024.
Vancouver Soyaltın UE, Demirci Yıldırım T, Taşkıran E, Develi A, Ekinci F, Demir B, Akar H. Treatment approach in our hypertriglyceridemia induced acute pancreatitis patients. İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi. 2015;1(3):129-33.
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