The Relation of Preterm Birth and Microbiota

Yıl 2018, Sayı: 4, 383 - 392, 20.04.2018

Canan Örüklü Nevin Hotun Şahin

Öz

One hundred trillion of symbiotic bacterial cells in every
human being make up the human microbiota. Microbiota protects tissues from
antigens and pathogens by increasing mucosal barrier resistance. In pregnancy
there are changes in the female body, especially in the vaginal microbial. In
studies, it has been reported that this alteration inhibits pathogenesis by the
secretion of antibacterial bacteriocins such as lactic acid, which can maintain
acid pH. The impaired vaginal environment is associated with pregnancy
complications, especially with the risk of preterm birth. This study discusses
the relationship between preterm birth and microbiota.

Anahtar Kelimeler

Preterm birth, microbiota, pregnancy

Erken Doğum ve Mikrobiyota İlişkisi

Öz

Her insanda bulunan yüz trilyon simbiyotik bakteri hücresi
insan mikrobiyotasını oluşturmaktadır. Mikrobiyota, mukozal bariyer direncini
artırarak dokuları antijen ve patojenlerden korumaktadır. Gebelikte kadın
vücudunda, özellikle de vajinal mikrobiyumda değişimler olmaktadır.  Çalışmalarda bu değişikliğin, asit pH'ını
koruyabilen laktik asit gibi antibakteriyel bakteriyosinlerin salgılanması
yoluyla patojen gelişimini inhibe ettiği bildirilmektedir. Bozulmuş vajinal ortam
gebelik komplikasyonlarıyla özellikle erken doğum riski ile ilişkilendirilmektedir.
Bu çalışmada erken doğum ve mikrobiyata ilişkisi tartışılmaktadır.

Anahtar Kelimeler

Erken doğum, mikrobiyota, gebelik

Kaynakça

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