Mass Transport in Arteries and The Localization of Atherosclerosis in Human

Yıl 2010, Cilt: 2 Sayı: 3, 53 - 62, 01.09.2010

B. Gutti A. A. Susu O. A. Fasanmade

Öz

Atherosclerosis is a disease of the large arteries that involves a characteristic accumulation of high-molecular weight lipoprotein in the arterial wall. This research focuses on the mass transport processes that mediate the focal accumulation of lipid in arteries and places particular emphasis on the role of fluid mechanical forces in modulating mass transport phenomena as well as analysis of the Damkholer numbers within the arterial surfaces. Blood phase controlled hypoxia was considered in the mass transport mechanisms emerge in the localization of atherosclerosis. The results of the analysis of Damkholer numbers indicated that there were no significant difference between the model derived values of the Damkholer numbers and the corresponding simulated values. Model values (D.7 for ATP, Dar=177 for ATP, Dac=002−.0 for LDL, 010 for LDL, 0.027−.10 for albumin, .02−.0 for LDL, 0010 for albumin, .0 for oxygen) and simulated value (D.8−490 for oxygen) and simulated value (DDaw=108−490 for oxygen) and simulated value (D.762 for oxygen, Dar= 1214 for LDL, ac=.214.58 for oxygen); where DDaw=1458 for oxygen); where Dar is Damkholer number, Dac is Damkholer number based on endothelial permeability and D aw is Damkholer number based on the wall consumption. The flux of LDL into the arterial wall depends on the plasma concentration and permeability P which for human aorta, is between the range of 5×104−25×10−3m/.s..5×10 −4−25×10e which for human aorta, is between the range of Thus, a correlation between P and plasma concentration enhances the localization of atherosclerotic plaques. e and plasma concentration enhances the localization of atherosclerotic plaques

Anahtar Kelimeler

Transport, Artheroclerosis, Arteries, Accumulation, Lipoprotein

Kaynakça

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