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Antioxidant and Antibacterial Effects of Some Medicinal Plants of Iran

Yıl 2019, Cilt: 6 Sayı: 1, 62 - 78, 16.03.2019
https://doi.org/10.21448/ijsm.514968

Öz

Medicinal plants used in the treatment of diseases earlier times are potential sources of new drugs. The present study was undertaken to study the chemical composition, antioxidant and antibacterial activity of certain medicinal plants of Iran by gas chromatography and mass spectrometry (GC/MS), DPPH and disk diffusion method. According to the results of GC/MS, there are 46 kinds of chemical compounds including mucilage, fatty acids, flavonoid and diterpenes in flower of Echium khuzistanicum. There are aldehydes (7.9%), phenols (7.5%), fatty acids (5.8%) and furfural (5.4%) in the methanol extract of Echinops cephalotes. Furfural, steroids, vitamin B and flavonoids are the main compounds of Marrubium anisodan. Results of the antibacterial test showed that Staphylococcus aureus and Bacillus subtilis were more sensitive to methanol extract of Echium khuzistanicum root. Pseudomonas auruginosa was more sensitive to DMSO extract of Marrubium anisodan at 600 mg/ml concentration. Maximum flavonoid and phenol contents were belonging to Echinops cephalotes. Marrubium anisodan showed the best DPPH free radical scavenging activity.

Kaynakça

  • [1]. Sharifi‐Rad, M., Mnayer, D., Morais‐Braga, M.F.B., Carneiro, J.N.P., Bezerra, C.F., Coutinho, H.D.M., Salehi, B., Martorell, M., del Mar Contreras, M., Soltani‐Nejad, A. (2018). "Echinacea plants as antioxidant and antibacterial agents: From traditional medicine to biotechnological applications". Phytother. Res., vol 32, pp. 1653-1663.
  • [2] Ali, S.S., Kasoju, N., Luthra, A., Singh, A., Sharanabasava, H., Sahu, A., Bora, U. (2008). "Indian medicinal herbs as sources of antioxidants". Food. Res. Int., vol 41, pp. 1-15.
  • [3] Wu, C., Chen, F., Wang, X., Kim, H.-J., He, G.-q., Haley-Zitlin, V., Huang, G. (2006). "Antioxidant constituents in feverfew (Tanacetum parthenium) extract and their chromatographic quantification". Food. Chem., vol 96, pp. 220-227.
  • [4] Granato, D., Shahidi, F., Wrolstad, R., Kilmartin, P., Melton, L.D., Hidalgo, F.J., Miyashita, K., van Camp, J., Alasalvar, C., Ismail, A.B. (2018). "Antioxidant activity, total phenolics and flavonoids contents: should we ban in vitro screening methods?". Food. Chem, vol 264, pp. 471-475.
  • [5] Pokhrel, H., Baishya, S., Phukan, B., Pillai, D., Rather, M.A. (2018). "Occurrence and Distribution of Multiple Antibiotic Resistance Bacteria of Public Health Significance in Backwaters and Aquaculture Farm". Int. J. Curr. Microbiol. App. Sci., vol 7, pp. 975-987.
  • [6] O’Bryan, C.A., Crandall, P.G., Ricke, S.C. (2018). "Antimicrobial Resistance in Foodborne Pathogens, Food and Feed Safety Systems and Analysis", 1th ed.; Elsevier: Netherland, 2018; pp. 99-115; 9780128118351.
  • [7] Ali, M., Khan, T., Fatima, K., Ali, Q.u.A., Ovais, M., Khalil, A.T., Ullah, I., Raza, A., Shinwari, Z.K., Idrees, M. (2018). "Selected hepatoprotective herbal medicines: evidence from ethnomedicinal applications, animal models, and possible mechanism of actions". Phytother. Res., vol 32, pp. 199-215.
  • [8] Khatamsaz, M. (2002). "Flora of Iran: Boraginacea"3rd ed.; Research Institute of forests and rangelands: Tehran, 2002; pp. 78-85.
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  • [10] Kim, J.Y., Jeong, H.J., Park, J.Y., Kim, Y.M., Park, S.J., Cho, J.K., Park, K.H., Ryu, Y.B., Lee, W.S. (2012). "Selective and slow-binding inhibition of shikonin derivatives isolated from Lithospermum erythrorhizon on glycosyl hydrolase 33 and 34 sialidases". Bioorg. Med. Chem., vol 20, pp. 1740-1748.
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  • [12] Li, F., Yin, Z., Zhou, B., Xue, F., Yang, W., Chang, R., Ma, K., Qiu, Y. (2015). "Shikonin inhibits inflammatory responses in rabbit chondrocytes and shows chondroprotection in osteoarthritic rabbit knee". Int. Immunopharmacol, vol 29, pp. 656-662.
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Antioxidant and Antibacterial Effects of Some Medicinal Plants of Iran

Yıl 2019, Cilt: 6 Sayı: 1, 62 - 78, 16.03.2019
https://doi.org/10.21448/ijsm.514968

Öz

Medicinal plants used in
the treatment of diseases earlier times are potential sources of new drugs. The
present study was undertaken to study the
chemical composition, antioxidant
and antibacterial activity of certain medicinal plants of Iran by
gas chromatography and mass spectrometry (GC/MS), DPPH and disk diffusion method. According to the
results of GC/MS, there are 46 kinds of chemical compounds including mucilage,
fatty acids, flavonoid and diterpenes in flower of Echium khuzistanicum.
There are aldehydes (7.9%), phenols (7.5%), fatty acids (5.8%) and furfural
(5.4%) in the methanol extract of Echinops cephalotes. Furfural,
steroids, vitamin B and flavonoids are the main compounds of Marrubium
anisodan
. Results of the antibacterial test showed that Staphylococcus
aureus
and Bacillus subtilis were more sensitive to methanol extract
of Echium khuzistanicum root. Pseudomonas auruginosa was more
sensitive to DMSO extract of Marrubium anisodan at 600 mg/ml
concentration. Maximum flavonoid and phenol contents were belonging to Echinops
cephalotes
. Marrubium anisodan showed the best DPPH free radical
scavenging activity.

Kaynakça

  • [1]. Sharifi‐Rad, M., Mnayer, D., Morais‐Braga, M.F.B., Carneiro, J.N.P., Bezerra, C.F., Coutinho, H.D.M., Salehi, B., Martorell, M., del Mar Contreras, M., Soltani‐Nejad, A. (2018). "Echinacea plants as antioxidant and antibacterial agents: From traditional medicine to biotechnological applications". Phytother. Res., vol 32, pp. 1653-1663.
  • [2] Ali, S.S., Kasoju, N., Luthra, A., Singh, A., Sharanabasava, H., Sahu, A., Bora, U. (2008). "Indian medicinal herbs as sources of antioxidants". Food. Res. Int., vol 41, pp. 1-15.
  • [3] Wu, C., Chen, F., Wang, X., Kim, H.-J., He, G.-q., Haley-Zitlin, V., Huang, G. (2006). "Antioxidant constituents in feverfew (Tanacetum parthenium) extract and their chromatographic quantification". Food. Chem., vol 96, pp. 220-227.
  • [4] Granato, D., Shahidi, F., Wrolstad, R., Kilmartin, P., Melton, L.D., Hidalgo, F.J., Miyashita, K., van Camp, J., Alasalvar, C., Ismail, A.B. (2018). "Antioxidant activity, total phenolics and flavonoids contents: should we ban in vitro screening methods?". Food. Chem, vol 264, pp. 471-475.
  • [5] Pokhrel, H., Baishya, S., Phukan, B., Pillai, D., Rather, M.A. (2018). "Occurrence and Distribution of Multiple Antibiotic Resistance Bacteria of Public Health Significance in Backwaters and Aquaculture Farm". Int. J. Curr. Microbiol. App. Sci., vol 7, pp. 975-987.
  • [6] O’Bryan, C.A., Crandall, P.G., Ricke, S.C. (2018). "Antimicrobial Resistance in Foodborne Pathogens, Food and Feed Safety Systems and Analysis", 1th ed.; Elsevier: Netherland, 2018; pp. 99-115; 9780128118351.
  • [7] Ali, M., Khan, T., Fatima, K., Ali, Q.u.A., Ovais, M., Khalil, A.T., Ullah, I., Raza, A., Shinwari, Z.K., Idrees, M. (2018). "Selected hepatoprotective herbal medicines: evidence from ethnomedicinal applications, animal models, and possible mechanism of actions". Phytother. Res., vol 32, pp. 199-215.
  • [8] Khatamsaz, M. (2002). "Flora of Iran: Boraginacea"3rd ed.; Research Institute of forests and rangelands: Tehran, 2002; pp. 78-85.
  • [9] Gao, H., Liu, L., Qu, Z.Y., Wei, F.X., Wang, S.Q. , Chen, G., Qin, L., Jiang, F.Y., Wang, Y.C., Shang, L., Gao, C.Y. (2011). "Anti-adenovirus activities of shikonin, a component of Chinese herbal medicine in vitro". Biol. Pharm. Bull., vol 34, pp. 197-202.
  • [10] Kim, J.Y., Jeong, H.J., Park, J.Y., Kim, Y.M., Park, S.J., Cho, J.K., Park, K.H., Ryu, Y.B., Lee, W.S. (2012). "Selective and slow-binding inhibition of shikonin derivatives isolated from Lithospermum erythrorhizon on glycosyl hydrolase 33 and 34 sialidases". Bioorg. Med. Chem., vol 20, pp. 1740-1748.
  • [11] Lee, Y.J., Choi, S.Y., Yang, J.H. (2014). "NMDA receptor-mediated ERK 1/2 pathway is involved in PFHxS-induced apoptosis of PC12 cells". Sci. Total. Environ., vol 1, pp. 491-492.
  • [12] Li, F., Yin, Z., Zhou, B., Xue, F., Yang, W., Chang, R., Ma, K., Qiu, Y. (2015). "Shikonin inhibits inflammatory responses in rabbit chondrocytes and shows chondroprotection in osteoarthritic rabbit knee". Int. Immunopharmacol, vol 29, pp. 656-662.
  • [13] Papageorgiou, V.P., Assimopoulou, A.N., Couladouros, E.A., Hepworth, D., Nicolaou, K.C. (1999). "The Chemistry and Biology of Alkannin, Shikonin, and Related Naphthazarin Natural Products". Angewandte. Chemie. International. Edition, vol 38, pp. 270-301.
  • [14] Skrzypczak, A., Przystupa, N., Zgadzaj, A., Parzonko, A., Syklowska-Baranek, K., Paradowska, K., Nalecz-Jawecki, G. (2015). "Antigenotoxic, anti-photogenotoxic and antioxidant activities of natural naphthoquinone shikonin and acetylshikonin and Arnebia euchroma callus extracts evaluated by the umu-test and EPR method". Toxicol. In Vitro, vol 30, pp. 364-372.
  • [15] Yang, Y., Wang, J., Yang, Q., Wu, S., Yang, Z., Zhu, H., Zheng, M., Liu, W., Wu, W., He, J., Chen, Z. (2014). "Shikonin inhibits the lipopolysaccharide-induced release of HMGB1 in RAW264.7 cells via IFN and NF-kappaB signaling pathways". Int. Immunopharmacol, vol 19, pp. 81-87.
  • [16] Fan, C., Xie, Y., Dong, Y., Su, Y., Upton, Z. (2015). "Investigating the potential of Shikonin as a novel hypertrophic scar treatment". J. Biomed. Sci., vol 22, pp. 1-13.
  • [17] Bursal, E., Aras, A., Kılıç, Ö. (2018). "Evaluation of antioxidant capacity of endemic plant Marrubium astracanicum subsp. macrodon: Identification of its phenolic contents by using HPLC-MS/MS". Nat. Prod. Res., vol pp. 1-5.
  • [18] Hymete, A., Iversen, T.H., Rohloff, J., Erko, B. (2005). "Screening of Echinops ellenbeckii and Echinops longisetus for biological activities and chemical constituents". Phytomedicine, vol 12, pp. 675-679.
  • [19] Ebrahimzadeh, M.A., Pourmorad, F., Bekhradnia, A.R. (2008). "Iron chelating activity, phenol and flavonoid content of some medicinal plants from Iran". Afr. J. Biotechnol., vol 7, pp.3188-3192 .
  • [20] Chang, W.C.S., Soon, C.K., Bong, S.H., Hye, K.C., Min, J.A., Sang, H.P., Soo,K.K. (2002). "Antioxidant activity and free radical scavenging capacity between Korean medicinal plants and flavonoids by assay-guided comparison". Plant. Sci., vol 163, pp. 1161-1168.
  • [21] Singleton, V.L., Rossi, J.A. (1965). "Colorimetry of Total Phenolics with Phosphomolybdic-Phosphotungstic Acid Reagents." Am. J. Enol. Viticult., vol 16, pp. 144-158.
  • [22] Shah, S.H.R, ZAhid, M., Mohammad, S., Mohammad. M.M., Aziz, U.R. (2016). "Evaluation of in vitro antioxidant and thrombolytic studies of some N-(2, 3-dihydro-1, 4-benzodioxan-6-yl)-4-methylbenzenesulfonamide-N-acetamide derivatives". J. Chem. Pharm. Res., vol 8, pp. 424-431.
  • [23] Mangena, T., Muyima, N. (1999). "Comparative evaluation of the antimicrobial activities of essential oils of Artemisia afra, Pteronia incana and Rosmarinus officinalis on selected bacteria and yeast strains". Lett. Appl. Microbiol., vol 28, pp. 291-296.
  • [24] Shi, W., Marcus, S.L., Lowary, T.L. (2010). "Synthesis and antibacterial activity of aminosugar-functionalized intercalating agents". Carbohydr. Res., vol 345, pp. 10-22.
  • [25] Martinez, A., Rodriguez, M.E., Wells, M.L., York, S.W., Preston, J.F., Ingram, L.O. (2001). "Detoxification of dilute acid hydrolysates of lignocellulose with lime". Biotech. Prog., vol 17, pp. 287-293.
  • [26] Boopathy, R., Bokang, H., Daniels, L. (1993). "Biotransformation of furfural and 5-hydroxymethyl furfural by enteric bacteria". J. Ind. Microbiol, vol 11, pp. 147-150.
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Toplam 63 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Yapısal Biyoloji
Bölüm Makaleler
Yazarlar

Samira Mohammadi Bu kişi benim 0000-0002-1909-7717

Khosro Piri Bu kişi benim

Mehri Dinarvand Bu kişi benim

Yayımlanma Tarihi 16 Mart 2019
Gönderilme Tarihi 14 Temmuz 2018
Yayımlandığı Sayı Yıl 2019 Cilt: 6 Sayı: 1

Kaynak Göster

APA Mohammadi, S., Piri, K., & Dinarvand, M. (2019). Antioxidant and Antibacterial Effects of Some Medicinal Plants of Iran. International Journal of Secondary Metabolite, 6(1), 62-78. https://doi.org/10.21448/ijsm.514968
International Journal of Secondary Metabolite
e-ISSN: 2148-6905