Histopathological and immunohistochemical characteristics of ventricular ependymoma in a goat

Yıl 2017, Cilt: 43 Sayı: 1, 77 - 80, 01.01.2017

Ghasem Farjanıkısh Azizollah Khodakaram-taftı

https://doi.org/10.16988/iuvfd.267285

Öz

    Ependymomas as primary
central nervous system neoplasms are occasionally observed in human infants
however; they are rare in animals. A three-year-old male goat was presented
with clinical neurological signs. At necropsy, a 3×2×2 cm, bulging, white-grey-
to red, soft mass extending into the left lateral ventricle of brain was
observed. Microscopically, the mass with densely cellular population was
nonencapsulated, mostly containing cuboidal-columnar neoplastic cells with
pseudo-rosettes formation. Mitotic figures were rare and malignancy indexes
were not observed. Neoplastic cells were immunohistochemically positive for Glial
Fibrillary Acidic Protein (GFAP), S-100, and vimentin; however, they did not
express Cytokeratins. On the basis of the location, histologic and
immunohistochemical findings, the tumor was diagnosed as an ependymoma.

Anahtar Kelimeler

Ependymoma, goat, immunohistochemistry

Kaynakça

• Cantile. C., Campani, D., Menicagli, M., Arispici, M., 2002. Pathological and immunohistochemical studies of choroid plexus carcinoma of the dog. Journal of Comparative Pathology 126, 183-193.
• Carrigan, M.J., Higgins, R.J., Carlson, G.P., Naydan, D.K., 1996. Equine papillary ependymoma. Veterinary Pathology 33, 77-80.
• Cordy, D.R., 1990. Tumors of the nervous system and eye. In: Meuten, D.J., Tumors in Domestic Animals, 4rd ed. University of California Press, Berkeley, CA, 2008., p. 645.
• Gilbert, M.R., Ruda, R., Soffietti, R., 2010. Ependymomas in adults. Current Neurology and Neuroscience Reports 10, 240-247.
• Koestner, A., Higgins, R.J., 2002. Tumors of the nervous system. In: Meuten D.J. (ed.): Tumours in Domestic Animals. 4th ed. Iowa State Press, Iowa. 707-709.
• McGill, I.S., Wells., G.A., 1993. Neuropathological findings in cattle with clinically suspect but histologically unconfirmed bovine spongiform encephalopathy (BSE). Journal of Comparative Pathology 108, 241-260.
• McKay, J.S., Targett, M.P., Jeffrey, N.D., 1999. Histological characterisation of an ependymoma in the fourth ventricle of a cat. Journal of Comparative Pathology 120, 105-113.
• Metellus, P., Guyotat, J., Chinot, O., Durand, A., Barrie, M., Giorgi, R., Jouvet, A., Figarella-Branger, D., 2010. Adult intracranial who grade II ependymomas: long-term outcome and prognostic factor analysis in a series of 114 patients. Neuro-oncology 12, 976-984.
• Michimae, Y., Morita, T., Sunagawa, Y., Sawada, M., Okamoto, Y., Shimada, A., 2004. Anaplastic ependymoma in the cervical spinal cord of a Maltese dog. Journal of Veterinary Medical Science 66, 1155-1158.
• Simpson, D.J., Hunt, G.B., Tisdall, P.L.C., Govendir, M., Zaki, S., France, M.P., Malik, R., 1999. Surgical removal of an ependymoma from the third ventricle of a cat. Australian Veterinary Journal 77, 645-648.
• Vernau, K.M., Higgins, R.J., Bollen, A.W., Jimenez, D.F., Anderson, J.V., Koblik, P.D., LeCouteur, R.A., 2001. Primary canine and feline nervous system tumors: Intraoperative diagnosis using the smear technique. Veterinary Pathology 38, 47-57.
• Vural, S.A., Besalti, O., Ilhan, F., Ozak, A., Haligur, M., 2006. Ventricular ependymoma in a German Shepherd dog. Veterinary Journal 172, 185-187.
• Wiestler, O.D., Schiffer, D., Coons, S.W., Prayson, R.A., Rosenblum, M.K. 2000. Ependymoma. In: Kleihues P., Cavenee W.K. (eds.): WHO Classification of Tumors Pathology and Genetics of Tumors of the Nervous System. IARC Press, Lyon, France. pp: 72-76.