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Hepatoprotective Activity of Indonesian Stingless Bee Propolis Against Toxicity of Anti-tuberculosis Drug on Pulmonary Tb Patients

Yıl 2018, Cilt: 1 Sayı: 3 - 2nd Propolis Conference Special Issue, 10 - 10, 08.12.2018

Öz

The usage of rifampicin,
isonoazid, pyrazinamide and ethambuthol to treat
tuberculosis
(
Tb) leads to hepatotoxicity which affects patient’s body weight
and
nutritional status. Numerous studies have shown
propolis to act as a hepatoprotector. This study aimed to
clinically evaluate the ability of propolis to protect the
liver from the toxic effects of
anti tuberculosis drug
(ATD)
and its impact on body weight and nutritional status changes of patients with pulmonary Tb. Randomized
clinical controlled trial, involving 50 subjects of lung T
b patients divided
into three groups: control (P0), propolis
1 supplementation (P1) and propolis 2 supplementation (P2); each subject
received intervention for 6 months. Biomarkers of liver toxicity; SGPT, SGOT,
BT, SOD and GSH were measured three times and body weight and nutritional
status were assessed weekly during treatment. Measurement of liver toxicity
biomarkers showed control groups experienced high liver oxidative damage during
the intensive treatment stage
as characterized by
bilirubin exceeding normal values. In contrast, the

supplementation propolis
groups showed no liver
oxidative damage
as indicated by normal bilirubin
concentrations. P2
group showed excellent hepatoprotective activity as showed by the lowest bilirubin, the greatest
decrease of SGPT and the best antioxidant status of GSH and SOD enzymes. This
group also showed
body weight and nutritional status increased from the beginning of the
intervention, while the other group decreased first. Pursuant to all
indicators, propolis 2 supplementation demonstrates liver protection from toxic
effects of OAT and prevents
decreased body weight and nutritional status of
pulmonary T
b patients.

Kaynakça

  • 1. Mahani, Sulaeman A, Anwar F, Damanik MRM, Hardinsyah, Ploeger A. 2018. Determination of Indonwsian native stingless bee propolis as complementary nutraceutical candidate of antituberculosis drug. Int J Pharm Pharm Sci 10 (4): 15-21 2. Mahani, Sulaeman A, Anwar F, Damanik MRM, Hardinsyah, Ploeger. 2018. Efficacy of Propolis Supplementation to Accelerate Healing Process and Body Weight Recovery of Pulmonary Tuberculosis Patients. J Gizi dan Pangan.
Yıl 2018, Cilt: 1 Sayı: 3 - 2nd Propolis Conference Special Issue, 10 - 10, 08.12.2018

Öz

Kaynakça

  • 1. Mahani, Sulaeman A, Anwar F, Damanik MRM, Hardinsyah, Ploeger A. 2018. Determination of Indonwsian native stingless bee propolis as complementary nutraceutical candidate of antituberculosis drug. Int J Pharm Pharm Sci 10 (4): 15-21 2. Mahani, Sulaeman A, Anwar F, Damanik MRM, Hardinsyah, Ploeger. 2018. Efficacy of Propolis Supplementation to Accelerate Healing Process and Body Weight Recovery of Pulmonary Tuberculosis Patients. J Gizi dan Pangan.
Toplam 1 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Bölüm 2nd Propolis Conference Special Issue
Yazarlar

Ahmad Sulaeman Bu kişi benim

M Mahanı Bu kişi benim

HARDINSYAH Hardınsyah Bu kişi benim

E Darma Bu kişi benim

S. R. Mubarokah Bu kişi benim

N Nurjanah Bu kişi benim

Yayımlanma Tarihi 8 Aralık 2018
Yayımlandığı Sayı Yıl 2018 Cilt: 1 Sayı: 3 - 2nd Propolis Conference Special Issue

Kaynak Göster

APA Sulaeman, A., Mahanı, M., Hardınsyah, H., Darma, E., vd. (2018). Hepatoprotective Activity of Indonesian Stingless Bee Propolis Against Toxicity of Anti-tuberculosis Drug on Pulmonary Tb Patients. Journal of Apitherapy and Nature, 1(3), 10-10.
AMA Sulaeman A, Mahanı M, Hardınsyah H, Darma E, Mubarokah SR, Nurjanah N. Hepatoprotective Activity of Indonesian Stingless Bee Propolis Against Toxicity of Anti-tuberculosis Drug on Pulmonary Tb Patients. J.Apit.Nat. Aralık 2018;1(3):10-10.
Chicago Sulaeman, Ahmad, M Mahanı, HARDINSYAH Hardınsyah, E Darma, S. R. Mubarokah, ve N Nurjanah. “Hepatoprotective Activity of Indonesian Stingless Bee Propolis Against Toxicity of Anti-Tuberculosis Drug on Pulmonary Tb Patients”. Journal of Apitherapy and Nature 1, sy. 3 (Aralık 2018): 10-10.
EndNote Sulaeman A, Mahanı M, Hardınsyah H, Darma E, Mubarokah SR, Nurjanah N (01 Aralık 2018) Hepatoprotective Activity of Indonesian Stingless Bee Propolis Against Toxicity of Anti-tuberculosis Drug on Pulmonary Tb Patients. Journal of Apitherapy and Nature 1 3 10–10.
IEEE A. Sulaeman, M. Mahanı, H. Hardınsyah, E. Darma, S. R. Mubarokah, ve N. Nurjanah, “Hepatoprotective Activity of Indonesian Stingless Bee Propolis Against Toxicity of Anti-tuberculosis Drug on Pulmonary Tb Patients”, J.Apit.Nat., c. 1, sy. 3, ss. 10–10, 2018.
ISNAD Sulaeman, Ahmad vd. “Hepatoprotective Activity of Indonesian Stingless Bee Propolis Against Toxicity of Anti-Tuberculosis Drug on Pulmonary Tb Patients”. Journal of Apitherapy and Nature 1/3 (Aralık 2018), 10-10.
JAMA Sulaeman A, Mahanı M, Hardınsyah H, Darma E, Mubarokah SR, Nurjanah N. Hepatoprotective Activity of Indonesian Stingless Bee Propolis Against Toxicity of Anti-tuberculosis Drug on Pulmonary Tb Patients. J.Apit.Nat. 2018;1:10–10.
MLA Sulaeman, Ahmad vd. “Hepatoprotective Activity of Indonesian Stingless Bee Propolis Against Toxicity of Anti-Tuberculosis Drug on Pulmonary Tb Patients”. Journal of Apitherapy and Nature, c. 1, sy. 3, 2018, ss. 10-10.
Vancouver Sulaeman A, Mahanı M, Hardınsyah H, Darma E, Mubarokah SR, Nurjanah N. Hepatoprotective Activity of Indonesian Stingless Bee Propolis Against Toxicity of Anti-tuberculosis Drug on Pulmonary Tb Patients. J.Apit.Nat. 2018;1(3):10-.
  • 23484   ASOS Index