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Plant Origin Authentication of Sonoran Propolis and its Antiproliferative Effect on Cancer Cells: A Bioactive Poplar Type Propolis from Semi-arid Zones

Yıl 2018, Cilt: 1 Sayı: 3 - 2nd Propolis Conference Special Issue, 15 - 15, 08.12.2018

Öz

The main chemical
composition of Sonoran propolis (SP), as well as its antiproliferative activity
on cancer cells via apoptosis induction has been reported
1.
Additionally, the chemical constitution of SP remained qualitatively similar
throughout the year, whereas the antiproliferative effect exhibited significant
differences amongst seasonal samples
2. The goal of this study was to
authenticate the
botanical
source of
SP bioactivity by using an approach based
on a chemical comparative analysis, antiproliferative activity and cell cycle
progression analysis on cancer cell lines. The polyphenolic profile of SP
throughout the year resulted to be qualitatively similar to that of
Populus
fremontii
resins (PFR). However, the antiproliferative activity of PFR did
not consistently match that exhibited by SP. In addition, SP induced evident
morphological modifications (elongation) on treated cells, different to those
induced by PFR. Most of cancer cells treated with SP were arrested in G
2/M
checkpoint (M12.C3.F6: 94.8±1.7 %, and HeLa cells: 70.8±5.7 %), similarly as
colchicine did (control drug; 2 µM; 94.8±2.3 % and 72.7±6.4 %, respectively).
In contrast, PFR treatment increased cell population at G
0/G1
on both M12.C3.F6 (56.9±5.0 %) and HeLa cells (70.3±0.3 %), in comparison with
dissolvent control. Interestingly,
Ambrosia confertiflora resins induced
morphological elongation and cell cycle arrest at G
2/M on both
M12.C3.F6 and HeLa cells, similarly as SP did. These results suggest that
P.
fremontii
is the main plant origin of SP, nevertheless, A. confertiflora
resins participate as a complementary source that enhances its bioactivity.
Therefore, SP is a poplar-type propolis from subtropical semi-arid zones. 

Kaynakça

  • 1. Alday E, Valencia D, Carreсo AL, Picerno P, Piccinelli AL, Rastrelli L, Robles-Zepeda R, Hernandez J, Velazquez C (2015) Apoptotic induction by pinobanksin and some of its ester derivatives from Sonoran propolis in a B-cell lymphoma cell line. Chemico-Biological Interactions 242: 35–44. 2.Valencia D, Alday E, Robles-Zepeda R, Garibay-Escobar A, Galvez-Ruiz JC, Salas-Reyes M, Jimйnez-Estrada M, Velazquez-Contreras E, Hernandez J, Velazquez C (2012). Seasonal effect on chemical composition and biological activities of Sonoran propolis. Food Chemistry 131: 645–651.
Yıl 2018, Cilt: 1 Sayı: 3 - 2nd Propolis Conference Special Issue, 15 - 15, 08.12.2018

Öz

Kaynakça

  • 1. Alday E, Valencia D, Carreсo AL, Picerno P, Piccinelli AL, Rastrelli L, Robles-Zepeda R, Hernandez J, Velazquez C (2015) Apoptotic induction by pinobanksin and some of its ester derivatives from Sonoran propolis in a B-cell lymphoma cell line. Chemico-Biological Interactions 242: 35–44. 2.Valencia D, Alday E, Robles-Zepeda R, Garibay-Escobar A, Galvez-Ruiz JC, Salas-Reyes M, Jimйnez-Estrada M, Velazquez-Contreras E, Hernandez J, Velazquez C (2012). Seasonal effect on chemical composition and biological activities of Sonoran propolis. Food Chemistry 131: 645–651.
Toplam 1 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Bölüm 2nd Propolis Conference Special Issue
Yazarlar

Efrain Alday Bu kişi benim

Lucía Urıbe Bu kişi benim

Dora Valencıa Bu kişi benim

Adriana Garıbay-escobar Bu kişi benim

Anna Lisa Pıccınellı Bu kişi benim

Luca Rastrellı Bu kişi benim

Humberto Astıazarán-garcía Bu kişi benim

Ramón Enrique Robles-zepeda Bu kişi benim

Javier Hernandez Bu kişi benim

Carlos Velazquez Bu kişi benim

Yayımlanma Tarihi 8 Aralık 2018
Yayımlandığı Sayı Yıl 2018 Cilt: 1 Sayı: 3 - 2nd Propolis Conference Special Issue

Kaynak Göster

APA Alday, E., Urıbe, L., Valencıa, D., Garıbay-escobar, A., vd. (2018). Plant Origin Authentication of Sonoran Propolis and its Antiproliferative Effect on Cancer Cells: A Bioactive Poplar Type Propolis from Semi-arid Zones. Journal of Apitherapy and Nature, 1(3), 15-15.
AMA Alday E, Urıbe L, Valencıa D, Garıbay-escobar A, Pıccınellı AL, Rastrellı L, Astıazarán-garcía H, Robles-zepeda RE, Hernandez J, Velazquez C. Plant Origin Authentication of Sonoran Propolis and its Antiproliferative Effect on Cancer Cells: A Bioactive Poplar Type Propolis from Semi-arid Zones. J.Apit.Nat. Aralık 2018;1(3):15-15.
Chicago Alday, Efrain, Lucía Urıbe, Dora Valencıa, Adriana Garıbay-escobar, Anna Lisa Pıccınellı, Luca Rastrellı, Humberto Astıazarán-garcía, Ramón Enrique Robles-zepeda, Javier Hernandez, ve Carlos Velazquez. “Plant Origin Authentication of Sonoran Propolis and Its Antiproliferative Effect on Cancer Cells: A Bioactive Poplar Type Propolis from Semi-Arid Zones”. Journal of Apitherapy and Nature 1, sy. 3 (Aralık 2018): 15-15.
EndNote Alday E, Urıbe L, Valencıa D, Garıbay-escobar A, Pıccınellı AL, Rastrellı L, Astıazarán-garcía H, Robles-zepeda RE, Hernandez J, Velazquez C (01 Aralık 2018) Plant Origin Authentication of Sonoran Propolis and its Antiproliferative Effect on Cancer Cells: A Bioactive Poplar Type Propolis from Semi-arid Zones. Journal of Apitherapy and Nature 1 3 15–15.
IEEE E. Alday, “Plant Origin Authentication of Sonoran Propolis and its Antiproliferative Effect on Cancer Cells: A Bioactive Poplar Type Propolis from Semi-arid Zones”, J.Apit.Nat., c. 1, sy. 3, ss. 15–15, 2018.
ISNAD Alday, Efrain vd. “Plant Origin Authentication of Sonoran Propolis and Its Antiproliferative Effect on Cancer Cells: A Bioactive Poplar Type Propolis from Semi-Arid Zones”. Journal of Apitherapy and Nature 1/3 (Aralık 2018), 15-15.
JAMA Alday E, Urıbe L, Valencıa D, Garıbay-escobar A, Pıccınellı AL, Rastrellı L, Astıazarán-garcía H, Robles-zepeda RE, Hernandez J, Velazquez C. Plant Origin Authentication of Sonoran Propolis and its Antiproliferative Effect on Cancer Cells: A Bioactive Poplar Type Propolis from Semi-arid Zones. J.Apit.Nat. 2018;1:15–15.
MLA Alday, Efrain vd. “Plant Origin Authentication of Sonoran Propolis and Its Antiproliferative Effect on Cancer Cells: A Bioactive Poplar Type Propolis from Semi-Arid Zones”. Journal of Apitherapy and Nature, c. 1, sy. 3, 2018, ss. 15-15.
Vancouver Alday E, Urıbe L, Valencıa D, Garıbay-escobar A, Pıccınellı AL, Rastrellı L, Astıazarán-garcía H, Robles-zepeda RE, Hernandez J, Velazquez C. Plant Origin Authentication of Sonoran Propolis and its Antiproliferative Effect on Cancer Cells: A Bioactive Poplar Type Propolis from Semi-arid Zones. J.Apit.Nat. 2018;1(3):15-.
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