CD3 Positive Gastric Plasmablastic Lymphoma in a HIV-Negative Patient: A Case Report

Yıl 2017, Cilt: 8 Sayı: 1, 35 - 38, 31.03.2017

Betul Bolat Kucukzeybek Aylin Orgen Calli Mehmet Ali Uyaroglu, Et Al.

https://doi.org/10.5799/jcei.328751

Öz

Plasmablastic lymphoma is a rare and aggressive lymphoma characterized by the diffuse proliferation of large
neoplastic cells resembling immunoblasts with an immunophenotype of plasma cells. A 47-year-old male was referred
to our hospital with gastrointestinal bleeding, and a mass 10 cm in diameter, was detected. An endoscopic biopsy was
performed subsequently. Histopathological examination of the biopsy material revealed ulcer, alterations associated
with ulcer, and further presented a diffuse infiltration of atypical cells with abundant cytoplasm and pleomorphic nuclei,
some with crush artifacts in lamina propria. Immunohistochemically, the tumor cells were negative for cytokeratin, CD2,
CD20, and PAX5; but they were positive for CD3, MUM1, CD38 and CD138. Ki67 proliferation index was as high as
95%. The case was signed out as CD3-positive plasmablastic lymphoma with clinical, histopathological and
immunohisto-chemical findings. The plasmablastic lymphoma case with an aberrant CD3 expression has been
presented here, which is rarely observed in stomach.

Anahtar Kelimeler

Plasmablastic lymphoma, CD3, gastric lymphoma

Kaynakça

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