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Yıl 2015, Cilt: 6 Sayı: 3, - , 25.10.2015

Gülay Bulut Ayşe Almalı Remzi Erten İrfan Bayram Mahfuz Turan Mehmet Bulut

https://doi.org/10.5799/ahinjs.01.2015.03.0541

Öz

Inflammatory myofibroblastic tumor is a borderline neoplasm with uncertain malignant potential. The most frequent site of localization is the lungs. The localization in larynx in the head-neck area is rather rare. The 11-year-old female patient had the symptom of hoarse voice, which had been continuing for three years. The laryngoscopy performed showed a polypoid tissue with a wide base, which involved the left vocal cord at full length. The polypoid tissue was completely excised. The histopathological examination performed demonstrated several myofibroblasts with intranuclear pseudoinclusions, which were surrounded by mixed inflammatory infiltrates in a myxoid stroma. No significant atypia, mitosis and necrosis were observed. The immunochemistry stains were positive for Vimentin, ALK and EMA in neoplastic cells. Alcian blue stain was positive in the myxoid stroma. The case was diagnosed with laryngeal inflammatory myofibroblastic tumor in the light of histopathological and immunohistochemical findings. Laryngeal inflammatory myofibroblastic tumor, a rare entity, should definitely be distinguished from malignant laryngeal tumors. Accurate diagnosis ensures that unnecessary and aggressive treatment methods are avoided and complete, organ-salvaging resection adequate for the inflammatory myofibroblastic tumor be conducted. J Clin Exp Invest 2015; 6 (3): 315-317

Anahtar Kelimeler

Inflammatory myofibroblastic tumor immunohistochemistry larynx

Kaynakça

  • Coffin CM, Fletcher CDM. Inflammatory myofibroblastic tumour. In: Fletcher CDM, Unni KK, Mertens F, eds. WHO Classification of Tumors: Pathology and Genetics of Tumors of Soft Tissue and Bone. Lyon, France:IARC Press; 2002:91–94.
  • Keen M, Cho HT, Savetsky L. Pseudotumor of the larynx--an unusual cause of airway obstruction. Otolaryngol Head Neck Surg 1986; 94:243-246.
  • Wenig BM, Devaney K, Bisceglia M. Inflammatory myofibroblastic tumor of the larynx. A clinicopathologic study of eight cases simulating a malignant spindle cell neoplasm. Cancer 1995;76:2217-2229.
  • Alhumaid H, Bukhari M, Rikabi A, et al. Laryngeal myofibroblastic
  • tumor: case series and literature review. Int J Health Sci (Qassim) 2011;5:187-195.
  • Rodrigues M, Taylor RJ, Sun CC, Wolf JS. Inflammatory myofibroblastic tumor of the larynx in a 2-year-old male. ORL J Otorhinolaryngol Relat Spec 2005;67:101-105.
  • Völker HU, Scheich M, Höller S, et al. Differential diagnosis of laryngeal spindle cell carcinoma and inflammatory myofibroblastic tumor - report of two cases with similar morphology. Diagn Pathol 2007;2:1.
  • Idrees MT, Huan Y, Woo P, et al. Inflammatory myofibroblastic
  • tumor of larynx: a benign lesion with variable morphological spectrum. Ann Diagn Pathol 2007;11:433–439.
  • Biron VL, Waghray R, Medlicott SA, Bosch JD. Inflammatory
  • pseudotumours of the larynx: three cases and a review of the literature. J Otolaryngol Head Neck Surg 2008;37:32-38.
  • Coffin CM, Watterson J, Priest JR, Dehner LP. Extrapulmonary
  • inflammatory myofibroblastic tumor (inflammatory pseudotumor). A clinicopathologic and immunohistochemical study of 84 cases. Am J Surg Pathol 1995;19:859–872.
  • Brcić I, Brcić L, Hutinec Z, et al. Laryngeal inflammatory myofibroblastic tumor in a man: a case report. Coll Antropol 2010;34:1127-1129.
  • Coffin CM, Hornick JL, Fletcher CD. Inflammatory myofibroblastic tumor: comparison of clinicopathologic, histologic, and immunohistochemical features including ALK expression in atypical and aggressive cases. Am J Surg Pathol 2007;31:509–520.
  • Ni C, Xu YY, Zhou SH, Wang SQ. Differential diagnosis of inflammatory myofibroblastic tumour and lowgrade myofibroblastic sarcoma: two case reports with a literature review. J Int Med Res 2011;39:311–320.
  • Corsi A, Ciofalo A, Leonardi M, et al. Recurrent inflammatory
  • myofibroblastic tumor of the glottis mimicking malignancy. Am J Otolaryngol 1997;18:121-126.

Laringeal inflamatuar myofibroblastik tümör: Nadir bir olgu

Yıl 2015, Cilt: 6 Sayı: 3, - , 25.10.2015

Gülay Bulut Ayşe Almalı Remzi Erten İrfan Bayram Mahfuz Turan Mehmet Bulut

https://doi.org/10.5799/ahinjs.01.2015.03.0541

Öz

İnflamatuar myofibroblastik tümör malignite potansiyeli belirsiz, borderline bir neoplazmdır. En sık yerleşim yeri akciğerlerdir. Baş-boyun bölgesinde larinks yerleşimi oldukça nadirdir. On-bir yaşında kız hastanın üç yıldır devam eden ses kısıklığı şikayeti vardı. Yapılan laringoskopide sol vokal kordu boylu boyunca tutan, geniş tabanlı polipoid doku izlendi. Polipoid doku tamamen eksize edildi. Yapılan histopatolojik incelemede miksoid bir stroma içerisinde mikst iltihabi infiltratla karışık halde, intranükleer psödoinklüzyonları olan çok sayıda miyofibroblast izlendi. Belirgin atipi, mitoz, nekroz görülmedi. Yapılan immünhistokimyasal incelemede neoplastik hücrelerde vimentin, ALK, EMA ile pozitif boyanma izlendi. Alcian blue ile miksoid stromada boyanma görüldü. Histopatolojik ve immünhistokimyasal bulgular eşliğinde olguya laringeal inflamatuar miyofibroblastik tümör tanısı konuldu. Nadir bir antite olan laringeal inflamatuar myofibroblastik tümör, malign laringeal tümörlerden mutlaka ayırt edilmelidir. Doğru teşhis, hastada gereksiz agresif tedavi yöntemlerinden kaçınmayı ve inflamatuar myofibroblastik tümör için yeterli olan organ koruyucu komplet rezeksiyon yapılmasını sağlar.

Anahtar kelimeler: İnflamatuar myofibroblastik tümör, immünhistokimya, larinks

Anahtar Kelimeler

İnflamatuar myofibroblastik tümör immünhistokimya larinks

Kaynakça

  • Coffin CM, Fletcher CDM. Inflammatory myofibroblastic tumour. In: Fletcher CDM, Unni KK, Mertens F, eds. WHO Classification of Tumors: Pathology and Genetics of Tumors of Soft Tissue and Bone. Lyon, France:IARC Press; 2002:91–94.
  • Keen M, Cho HT, Savetsky L. Pseudotumor of the larynx--an unusual cause of airway obstruction. Otolaryngol Head Neck Surg 1986; 94:243-246.
  • Wenig BM, Devaney K, Bisceglia M. Inflammatory myofibroblastic tumor of the larynx. A clinicopathologic study of eight cases simulating a malignant spindle cell neoplasm. Cancer 1995;76:2217-2229.
  • Alhumaid H, Bukhari M, Rikabi A, et al. Laryngeal myofibroblastic
  • tumor: case series and literature review. Int J Health Sci (Qassim) 2011;5:187-195.
  • Rodrigues M, Taylor RJ, Sun CC, Wolf JS. Inflammatory myofibroblastic tumor of the larynx in a 2-year-old male. ORL J Otorhinolaryngol Relat Spec 2005;67:101-105.
  • Völker HU, Scheich M, Höller S, et al. Differential diagnosis of laryngeal spindle cell carcinoma and inflammatory myofibroblastic tumor - report of two cases with similar morphology. Diagn Pathol 2007;2:1.
  • Idrees MT, Huan Y, Woo P, et al. Inflammatory myofibroblastic
  • tumor of larynx: a benign lesion with variable morphological spectrum. Ann Diagn Pathol 2007;11:433–439.
  • Biron VL, Waghray R, Medlicott SA, Bosch JD. Inflammatory
  • pseudotumours of the larynx: three cases and a review of the literature. J Otolaryngol Head Neck Surg 2008;37:32-38.
  • Coffin CM, Watterson J, Priest JR, Dehner LP. Extrapulmonary
  • inflammatory myofibroblastic tumor (inflammatory pseudotumor). A clinicopathologic and immunohistochemical study of 84 cases. Am J Surg Pathol 1995;19:859–872.
  • Brcić I, Brcić L, Hutinec Z, et al. Laryngeal inflammatory myofibroblastic tumor in a man: a case report. Coll Antropol 2010;34:1127-1129.
  • Coffin CM, Hornick JL, Fletcher CD. Inflammatory myofibroblastic tumor: comparison of clinicopathologic, histologic, and immunohistochemical features including ALK expression in atypical and aggressive cases. Am J Surg Pathol 2007;31:509–520.
  • Ni C, Xu YY, Zhou SH, Wang SQ. Differential diagnosis of inflammatory myofibroblastic tumour and lowgrade myofibroblastic sarcoma: two case reports with a literature review. J Int Med Res 2011;39:311–320.
  • Corsi A, Ciofalo A, Leonardi M, et al. Recurrent inflammatory
  • myofibroblastic tumor of the glottis mimicking malignancy. Am J Otolaryngol 1997;18:121-126.
Toplam 18 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Araştırma Yazısı
Yazarlar

Gülay Bulut

Ayşe Almalı Bu kişi benim

Remzi Erten Bu kişi benim

İrfan Bayram Bu kişi benim

Mahfuz Turan Bu kişi benim

Mehmet Bulut Bu kişi benim

Yayımlanma Tarihi 25 Ekim 2015
Yayımlandığı Sayı Yıl 2015 Cilt: 6 Sayı: 3

Kaynak Göster

APA Bulut, G., Almalı, A., Erten, R., Bayram, İ., vd. (2015). Laringeal inflamatuar myofibroblastik tümör: Nadir bir olgu. Journal of Clinical and Experimental Investigations, 6(3). https://doi.org/10.5799/ahinjs.01.2015.03.0541
AMA Bulut G, Almalı A, Erten R, Bayram İ, Turan M, Bulut M. Laringeal inflamatuar myofibroblastik tümör: Nadir bir olgu. J Clin Exp Invest. Kasım 2015;6(3). doi:10.5799/ahinjs.01.2015.03.0541
Chicago Bulut, Gülay, Ayşe Almalı, Remzi Erten, İrfan Bayram, Mahfuz Turan, ve Mehmet Bulut. “Laringeal Inflamatuar Myofibroblastik tümör: Nadir Bir Olgu”. Journal of Clinical and Experimental Investigations 6, sy. 3 (Kasım 2015). https://doi.org/10.5799/ahinjs.01.2015.03.0541.
EndNote Bulut G, Almalı A, Erten R, Bayram İ, Turan M, Bulut M (01 Kasım 2015) Laringeal inflamatuar myofibroblastik tümör: Nadir bir olgu. Journal of Clinical and Experimental Investigations 6 3
IEEE G. Bulut, A. Almalı, R. Erten, İ. Bayram, M. Turan, ve M. Bulut, “Laringeal inflamatuar myofibroblastik tümör: Nadir bir olgu”, J Clin Exp Invest, c. 6, sy. 3, 2015, doi: 10.5799/ahinjs.01.2015.03.0541.
ISNAD Bulut, Gülay vd. “Laringeal Inflamatuar Myofibroblastik tümör: Nadir Bir Olgu”. Journal of Clinical and Experimental Investigations 6/3 (Kasım 2015). https://doi.org/10.5799/ahinjs.01.2015.03.0541.
JAMA Bulut G, Almalı A, Erten R, Bayram İ, Turan M, Bulut M. Laringeal inflamatuar myofibroblastik tümör: Nadir bir olgu. J Clin Exp Invest. 2015;6. doi:10.5799/ahinjs.01.2015.03.0541.
MLA Bulut, Gülay vd. “Laringeal Inflamatuar Myofibroblastik tümör: Nadir Bir Olgu”. Journal of Clinical and Experimental Investigations, c. 6, sy. 3, 2015, doi:10.5799/ahinjs.01.2015.03.0541.
Vancouver Bulut G, Almalı A, Erten R, Bayram İ, Turan M, Bulut M. Laringeal inflamatuar myofibroblastik tümör: Nadir bir olgu. J Clin Exp Invest. 2015;6(3).