Blepharospasm induced by systemic isotretinoin

Yıl 2019, Cilt: 10 Sayı: 2, 33 - 35, 01.04.2019

Gülhan Gülhan Gürel Hikmet Sacmacı

https://doi.org/10.33706/jemcr.550841

Öz

Introduction:Isotretinoin
(13-cis-retinoic acid), a synthetic analog of vitamin A, is commonly used in
the treatment of nodulocytic acne, which is resistant to other treatments. The
most common side effects of systemic isotretinoin treatment are dry mucous
membranes and dry skin. Blepharospasm is a movement disorder characterized by
hyperactivity of orbicularis oculi and other muscles around the eye.

Case
Report: We report here  a 33-year-old
female patient developed blepharospasm during treatment with systemic
isotretinoin. She consulted an ophthalmologist about her eye problem and was
diagnosed as having ‘dry eye’. Blepharospasm did not improve even though she
received artificial tears treatment. Magnetic resonance imaging and magnetic
resonance angiography were performed to investigate the etiology of
blepharospasm and no pathological findings were found.

Conclusion:
We
present a case of blepharospasm due to isotretinoin. Based on PubMed database,
this is the first clinical case of blepharospasm induced by isotretinoin. 

Anahtar Kelimeler

Blepharospasm, isotretinoin

Kaynakça

• 1. Demirseren DD, Kilinc F, Emre S, Akyol M, Metin A, Aktas A. The weeks and the cumulative doses of the first adverse events related to oral isotretinoin in acne patients: analysis of 300 patients. J Dermatolog Treat. 2017;28:309-313.
• 2. Brzezinski P, Borowska K, Chiriac A, Smigielski J. Adverse effects of isotretinoin: A large, retrospective review. Dermatol Ther. 2017;30(4).
• 3. Moy A, McNamara NA, Lin MC. Effects of Isotretinoin on Meibomian Glands. Optom Vis Sci. 2015;92:925-930.
• 4. Defazio G, Hallett M, Jinnah HA, Conte A, Berardelli A. Blepharospasm 40 years later. Mov Disord. 2017;32:498-509.
• 5. Emoto Y, Emoto H, Oishi E, Hikita S, Wakakura M. Twelve cases of drug-induced blepharospasm improved within 2 months of psychotropic cessation. Drug Healthc Patient Saf. 2011;3:9-14.
• 6. Khooshnoodi MA, Factor SA, Jinnah HA. Secondary blepharospasm associated with structural lesions of the brain. J Neurol Sci. 2013;331:98-101.
• 7. Kiliç A, Erten E, Özdemir A. Tardive Blepharospasm and Meige Syndrome during Treatment with Quetiapine and Olanzapine. Noro Psikiyatr Ars. 2015;52:207-209.
• 8. Suzuki Y, Kiyosawa M, Wakakura M, Mochizuki M, Ishiwata K, Oda K, et al. Glucose hypermetabolism in the thalamus of patients with drug-induced blepharospasm. Neuroscience. 2014;263:240-249.
• 9. Neudorfer M, Goldshtein I, Shamai-Lubovitz O, Chodick G, Dadon Y, Shalev V. Ocular adverse effects of systemic treatment with isotretinoin. Arch Dermatol. 2012;148:803-808.
• 10. Valls-Sole J, Defazio G. Blepharospasm: Update on Epidemiology, Clinical Aspects, and Pathophysiology. Front Neurol. 2016;7:45.