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Brucellosis in Kosovo and Clinical Features of Brucellosis at University clinical center of Kosovo

Yıl 2015, Cilt: 5 Sayı: 4, 147 - 150, 06.02.2016
https://doi.org/10.5799/ahinjs.02.2015.04.0195

Öz

Objective: Brucellosis became a remarkable disease in Kosovo. But there is not a comprehensive epidemiological study about pidemiology and clinical course of this disease from Kosovo. The aim of our study is to present demographic and clinical data of patients with brucellosis at University Clinical Center of Kosovo.

Methods: A retrospective study was performed for the patients with brucellosis treated in our clinic during years 2011- 2012. The data about demography, history of the disease, clinical presentations, serological test, serum biochemistry and treatment were collected from hospital medical records. The diagnosis of brucellosis based on clinical and laboratory findings.

Results: This descriptive study included 47 patients, who 33 of them (70.2%) were males. The mean age was 37.9 ± 19.3 years. The route of transmission of the disease was known in 28 (59.5%) of them. Direct contact with livestock in 22 (46.8%) and ingestion of dairy products in six cases (12.7%) were reported as the transmission route. The majority of patients (27 patients, 57.4%) were from rural area. The main presenting symptoms were fatigue, fever and arthralgia. Osteoarticular manifestations were the common forms of localized disease. Regarding to the therapy, 45 (95.7%) of patients were treated with streptomycin and doxycycline for the first three weeks.

Conclusion: Human brucellosis is not a common in Kosovo but there is a potential risk. Osteoarticular symptoms were the most common presentation reasons. The most effective and preferred treatment regimen was Streptomycin plus Doxycycline for the first three weeks, and Doxycycline plus Rifampicin thereafter. J Microbiol Infect Dis 2015;5(4): 147-150

Key words: Brucellosis, fever, osteoarticular involvement

Kaynakça

  • Muçaj S, Kabashi S, Gashi S, et al. Topographic expansion of Brucellosis in Kosovo. Materia Socio Medica 2009; Vol.21:No.2.
  • Shkodra B. Brucellosis in Gjilan Region during 2010-2012.The 1st International Conference on “Research and Education Challenges Towards the Future” (ICRAE 2013), 24-25May 2013.
  • Jackson R, Pite L, Kennard R, et al. Survey of the seroprevalence
  • of brucellosis in ruminants in Kosovo. Vet Rec 2004;12;154:747-751.
  • Yumuk Z, O’Callaghan D. Brucellosis in Turkey- an overview,Int J Infect Dis 2012; 16:e228-e235.
  • Buzgan T, Karahocagil MK, Irmak H, et al. Clinical manifestations
  • and complications in 1028 cases of brucellosis: a retrospective
  • evaluation and review of the literature. Int J Infect Dis. 2010; 14:e469-e478.
  • Sauret JM, Vilissova N. Human Brucellosis. JABFP. September-October 2002; vol.15;5.
  • Franco MP1, Mulder M, Gilman RH, et al. Human brucellosis.
  • Lancet Infect Dis 2007;7:775-786.
  • Mantur BG, Biradar MS, Bidri RC, et al. Protean clinical manifestations and diagnostic challenges of human brucellosis
  • in adults: 16 years’ experience in an endemic area. J Med Microbiol. 2006;55(Pt 7):897-903.
  • Ioannis G, Nikoleta MN, Maria E, et al. Presentation of childhood brucellosis in western Greece. Jpn J Infect Dis 2006;59:160-163.
  • Giannakopoulos I, Nikolakopoulou NM, Eliopoulou M, et al.
  • The new global map of human brucellosis. Jpn J Infect Dis. 2006;59:160-163.
  • Black TF. Brucellosis. In: Cohen J, Powderly WG editor. Infectious
  • diseases. 2nd ed. St. Louis: Mosby 2004;1665-1667.
  • Kassiri H, Amani H, Lotfi M. Epidemiological, laboratory, diagnostic and public health aspects of human brucellosis in western Iran. Asian Pac J Trop Biomed. 2013;3:589-594.
  • Guler S, Kokoglu OF, Ucmak H, et al. Human brucellosis in
  • Turkey: different clinical presentations. J Infect Dev Ctries. 2014 May 14;8:581-588.
  • Pappas G, Akritidis N, Bosilkovski M, et al. Brucellosis. N
  • Engl J Med 2005;352:2325-2336.
  • Ertek M, Yazgi H, Kadanali A, et al. Complications of Brucella
  • infection among adults: an 18-year retrospective evaluation. Turk J Med Sci 2006;36:377-381.
  • Solera J, Rodríguez-Zapata M, Geijo P, et al. Doxycyclinerifampin
  • versus doxycycline-streptomycin in treatment of human brucellosis due to Brucella melitensis. Antimicrob Agents Chemother 1995;39:2061-2067.

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Yıl 2015, Cilt: 5 Sayı: 4, 147 - 150, 06.02.2016
https://doi.org/10.5799/ahinjs.02.2015.04.0195

Öz

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Kaynakça

  • Muçaj S, Kabashi S, Gashi S, et al. Topographic expansion of Brucellosis in Kosovo. Materia Socio Medica 2009; Vol.21:No.2.
  • Shkodra B. Brucellosis in Gjilan Region during 2010-2012.The 1st International Conference on “Research and Education Challenges Towards the Future” (ICRAE 2013), 24-25May 2013.
  • Jackson R, Pite L, Kennard R, et al. Survey of the seroprevalence
  • of brucellosis in ruminants in Kosovo. Vet Rec 2004;12;154:747-751.
  • Yumuk Z, O’Callaghan D. Brucellosis in Turkey- an overview,Int J Infect Dis 2012; 16:e228-e235.
  • Buzgan T, Karahocagil MK, Irmak H, et al. Clinical manifestations
  • and complications in 1028 cases of brucellosis: a retrospective
  • evaluation and review of the literature. Int J Infect Dis. 2010; 14:e469-e478.
  • Sauret JM, Vilissova N. Human Brucellosis. JABFP. September-October 2002; vol.15;5.
  • Franco MP1, Mulder M, Gilman RH, et al. Human brucellosis.
  • Lancet Infect Dis 2007;7:775-786.
  • Mantur BG, Biradar MS, Bidri RC, et al. Protean clinical manifestations and diagnostic challenges of human brucellosis
  • in adults: 16 years’ experience in an endemic area. J Med Microbiol. 2006;55(Pt 7):897-903.
  • Ioannis G, Nikoleta MN, Maria E, et al. Presentation of childhood brucellosis in western Greece. Jpn J Infect Dis 2006;59:160-163.
  • Giannakopoulos I, Nikolakopoulou NM, Eliopoulou M, et al.
  • The new global map of human brucellosis. Jpn J Infect Dis. 2006;59:160-163.
  • Black TF. Brucellosis. In: Cohen J, Powderly WG editor. Infectious
  • diseases. 2nd ed. St. Louis: Mosby 2004;1665-1667.
  • Kassiri H, Amani H, Lotfi M. Epidemiological, laboratory, diagnostic and public health aspects of human brucellosis in western Iran. Asian Pac J Trop Biomed. 2013;3:589-594.
  • Guler S, Kokoglu OF, Ucmak H, et al. Human brucellosis in
  • Turkey: different clinical presentations. J Infect Dev Ctries. 2014 May 14;8:581-588.
  • Pappas G, Akritidis N, Bosilkovski M, et al. Brucellosis. N
  • Engl J Med 2005;352:2325-2336.
  • Ertek M, Yazgi H, Kadanali A, et al. Complications of Brucella
  • infection among adults: an 18-year retrospective evaluation. Turk J Med Sci 2006;36:377-381.
  • Solera J, Rodríguez-Zapata M, Geijo P, et al. Doxycyclinerifampin
  • versus doxycycline-streptomycin in treatment of human brucellosis due to Brucella melitensis. Antimicrob Agents Chemother 1995;39:2061-2067.
Toplam 27 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Bölüm Kısa Rapor
Yazarlar

Emine Buçaj Bu kişi benim

Edmond Puca Bu kişi benim

Sadie Namani Bu kişi benim

Muharem Bajrami Bu kişi benim

Valbon Krasniqi Bu kişi benim

Lindita Berisha Bu kişi benim

Xhevat Jakupi Bu kişi benim

Bahrie Halili Bu kişi benim

Dhimiter Kraja Bu kişi benim

Yayımlanma Tarihi 6 Şubat 2016
Yayımlandığı Sayı Yıl 2015 Cilt: 5 Sayı: 4

Kaynak Göster

APA Buçaj, E., Puca, E., Namani, S., Bajrami, M., vd. (2016). Brucellosis in Kosovo and Clinical Features of Brucellosis at University clinical center of Kosovo. Journal of Microbiology and Infectious Diseases, 5(4), 147-150. https://doi.org/10.5799/ahinjs.02.2015.04.0195
AMA Buçaj E, Puca E, Namani S, Bajrami M, Krasniqi V, Berisha L, Jakupi X, Halili B, Kraja D. Brucellosis in Kosovo and Clinical Features of Brucellosis at University clinical center of Kosovo. J Microbil Infect Dis. Şubat 2016;5(4):147-150. doi:10.5799/ahinjs.02.2015.04.0195
Chicago Buçaj, Emine, Edmond Puca, Sadie Namani, Muharem Bajrami, Valbon Krasniqi, Lindita Berisha, Xhevat Jakupi, Bahrie Halili, ve Dhimiter Kraja. “Brucellosis in Kosovo and Clinical Features of Brucellosis at University Clinical Center of Kosovo”. Journal of Microbiology and Infectious Diseases 5, sy. 4 (Şubat 2016): 147-50. https://doi.org/10.5799/ahinjs.02.2015.04.0195.
EndNote Buçaj E, Puca E, Namani S, Bajrami M, Krasniqi V, Berisha L, Jakupi X, Halili B, Kraja D (01 Şubat 2016) Brucellosis in Kosovo and Clinical Features of Brucellosis at University clinical center of Kosovo. Journal of Microbiology and Infectious Diseases 5 4 147–150.
IEEE E. Buçaj, “Brucellosis in Kosovo and Clinical Features of Brucellosis at University clinical center of Kosovo”, J Microbil Infect Dis, c. 5, sy. 4, ss. 147–150, 2016, doi: 10.5799/ahinjs.02.2015.04.0195.
ISNAD Buçaj, Emine vd. “Brucellosis in Kosovo and Clinical Features of Brucellosis at University Clinical Center of Kosovo”. Journal of Microbiology and Infectious Diseases 5/4 (Şubat 2016), 147-150. https://doi.org/10.5799/ahinjs.02.2015.04.0195.
JAMA Buçaj E, Puca E, Namani S, Bajrami M, Krasniqi V, Berisha L, Jakupi X, Halili B, Kraja D. Brucellosis in Kosovo and Clinical Features of Brucellosis at University clinical center of Kosovo. J Microbil Infect Dis. 2016;5:147–150.
MLA Buçaj, Emine vd. “Brucellosis in Kosovo and Clinical Features of Brucellosis at University Clinical Center of Kosovo”. Journal of Microbiology and Infectious Diseases, c. 5, sy. 4, 2016, ss. 147-50, doi:10.5799/ahinjs.02.2015.04.0195.
Vancouver Buçaj E, Puca E, Namani S, Bajrami M, Krasniqi V, Berisha L, Jakupi X, Halili B, Kraja D. Brucellosis in Kosovo and Clinical Features of Brucellosis at University clinical center of Kosovo. J Microbil Infect Dis. 2016;5(4):147-50.