Evaluation of atherosclerosis risk by measurement of intima media thickness and pulse wave velocity in lichen planus patients; A prospective case-control study

Yıl 2017, Cilt: 1 Sayı: 3, 40 - 43, 10.12.2017

Saliha Koç Murathan Küçük Veysel Tosun Can Ramazan Öncel Erkan Alpsoy Ertan Yılmaz

https://doi.org/10.28982/josam.344718

Öz

Aim: Lichen planus (LP) is one of the chronic inflammatory diseases. Chronic inflammation may play an important role in the development of subclinical atherosclerosis. In this study, we aimed to investigate the relationship between LP and atherosclerosis by using carotid intima media thickness (CIMT) and pulse wave velocity (PWV) measurements.

Methods: A controlled study is designed, two groups were formed as LP and control group. Forty LP patients (32 female and 8 male; mean age 44.6±1.2 years) and 40 healthy (control) individuals (32 female and 8 male; mean age 41.2±0.9 years) enrolled in the study. Individuals with atherosclerotic risk factors were excluded from the study for both groups. Demographic and biochemical data were recorded for both groups. CIMT and PWV measurements were compared between healthy and LP patients. 

Results: Maximum and average CIMT values in LP patients were significantly higher than the control group (Right maximum CIMT; 0.77±0.01 vs. 0.74±0.01, p=0.01, Left maximum CIMT; 0.80±0.01 vs. 0.76±0.01, p=0.011, Right average CIMT; 0.65±0.01 vs. 0.63±0.01, p=0.039, Left average CIMT; 0.68±0.01 vs. 0.64±0.01, p=0.005, respectively). No statistically significant difference was found between LP patients and control group for PWV (6.34±0.30 vs. 6.79±0.70 respectively, p=0.131). 

Conclusions: Our study demonstrated that CIMT was increased in patients with LP who had no clinical evidence of heart disease. LP patients were under an increased risk of subclinical atherosclerotic vascular dysfunction and structural changes.

Anahtar Kelimeler

lichen planus, carotis intima media thickness, pulse wave velocity, atherosclerosis

Liken planus hastalarında ateroskleroz riskinin intima media kalınlığı ve nabız dalga hızı ile değerlendirilmesi; Prospektif olgu-kontrol çalışması

Öz

Amaç: Liken Planus (LP) kronik inflamatuar hastalıklardan birisidir. Kronik inflamasyon subklinik ateroskleroz gelişiminde önemli bir role sahip olabilir. Bu çalışmamızda, LP ile ateroskleroz arasındaki ilişkiyi karotis intima medya kalınlığı (KİMK) ve nabız dalga hızı (NDH) ölçümlerini kullanarak araştırmayı amaçladık.

Yöntemler: Kontrollü çalışma planlandı ve LP ve kontrol grubu olmak üzere iki grup oluşturuldu. Kırk LP hastası (ortalama yaşı 44.6±1.2 olan 32 bayan ve 8 erkek) ve 40 sağlıklı birey (ortalama yaşı 41.2±0.9 olan 32 bayan ve 8 erkek) çalışmaya alındı. Her iki grupta da aterosklerotik risk faktörleri olan hastalar çalışmadan dışlandı. Her iki grubun demografik ve biyokimyasal parametreleri kaydedildi. Sağlıklı bireyler ve LP hastalarında KİMK ve NDH ölçümleri karşılaştırıldı. 

Bulgular: Maksimum ve ortalama KİMK değerleri LP hastalarında kontrol grubuna göre anlamlı olarak daha yüksek saptandı (sırasıyla; sağ maksimum KİMK; 0.77±0.01 ve 0.74±0.01 p=0.01, sol maksimum KİMK; 0.80±0.01 ve 0.76±0.01 p=0.011, sağ ortalama KİMK; 0.65±0.01 ve 0.63±0.01 p=0.039, sol ortalama KİMK; 0.68±0.01 vs. 0.64±0.01, p=0.005). LP hastaları ve kontrol grubu arasında NDH ölçümleri açısından anlamlı istatistiksel farklılık gözlenmedi (sırasıyla; 6.34±0.30 ve 6.79±0.70, p=0.131).

Sonuçlar:  Bizim çalışmamıza göre kalp hastalığı olmayan LP hastalarında KİMK değerleri daha yüksek oranlarda gösterildi. LP hastaları subklinik ateroskleroza bağlı vasküler disfonksiyon ve yapısal değişiklikler açısından risk altındadırlar.

Anahtar Kelimeler

liken planus, karotis intima medya kalınlığı, nabız dalga hızı, ateroskleroz

Kaynakça

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