Olgu Sunumu
BibTex RIS Kaynak Göster

Dasatinib tedavisine bağlı eşzamanlı gelişen plevral ve perikardiyal efüzyon: Olgu sunumu

Yıl 2018, Cilt: 2 Sayı: 2, 148 - 150, 01.05.2018
https://doi.org/10.28982/josam.393898

Öz

Dasatinib, imatinib tedavisine hematolojik ve/veya sitogenetik yanıt alınamayan yeni tanı almış Philadelphia Kromozomu (Ph1) pozitif kronik miyeloid lösemi (KML) tedavisinde kanıtlanmış potent bir tirozin kinaz inhibitörüdür. Dasatinib tedavisine bağlı plevral ve perikardiyal efüzyonlar ilacın başlanmasından genellikle 5-30 hafta sonra görülebilmekle beraber, herhangi bir zaman aralığında da gelişebilir. Plevral efüzyonlar sıklıkla bilateral ve eksüda karakterinde olup lenfosit hücre hakimiyeti çoğunlukla gözlenmektedir. Dasatinib tedavisine devam edilmemesi durumunda ortaya çıkan yan etkilerin büyük oranda gerilediği gözlemlenmiştir. Bu yazıda, dasatinib tedavisi altında New York Heart Association (NYHA) fonksiyonel clas III dispne ile başvuran, eş zamanlı plevral ve perikardiyal efüzyon gelişen, literatürde nadir gözlemlenen bir vaka sunuldu. Bu olguyu sunma amacımız, Dasatinib tedavisinde eşzamanlı plevral ve perikardiyal efüzyon gelişiminin nadir görülmesi, tedavi öncesi ve süresince yapılacak aralıklı kardiyopulmoner değerlendirmenin KML hastalarının takibindeki önemini bir kez daha vurgulamaktır.

Kaynakça

  • 1. Hillman RS, Ault KA, Leporrier M, Rinder HM. Robert S. Hematology in clinical practice; 5th ed. 2010. pp. 229-245.
  • 2. Dumitrescu D, Seck C, ten Freyhaus H, Gerhardt F, Erdmann E, Rosenkranz S. Fully reversible pulmonar y arterial hypertension associated with dasatinib treatment for chronic myeloid leukaemia. Eur Respir J. 2011;38:218–20.
  • 3. Bergeron A, Rea D, Levy V, Picard C, Meignin V, Tamburini J, et al. Lung abnormalities after dasatinib treatment for chronic myeloid leukemia: a case series. Am J Respir Crit Care Med. 2007;176(8):814–8.
  • 4. Montani D, Bergot E, Günther S, Savale L, Bergeron A, Bourdin A, et al. Pulmonary arterial hypertension in patients treated by dasatinib. Circulation. 2012;125:2128–37.
  • 5. Sillaber C, Herrmann H, Bennett K, Rix U, Baumgartner C, et al. Immunosuppression and atypical infections in CML patients treated with dasatinib at 140 mg daily. Eur J Clin Invest. 2009;39(12):1098–109.
  • 6. Lombardo LJ, Lee FY, Chen P, Norris D, Barrish JC, Behnia K, et al. Discovery of N-(2-chloro-6-methyl-phenyl)-2-(6-(4-[2-hydroxyethyl]-piperazin-1-yl)-2-methylpyrimidin-4-ylamino) thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays. J MedChem. 2004;47:6658–61.
  • 7. Breccia M, Latagliata R, Stagno F, Luciano L, Gozzini A, Castagnetti F, et al. Charlson comorbidity index and adult comorbidity evaluation-27 scores might predict treatment compliance and development of pleural effusions in elderly patients with chronic myeloid leukemia treated with second-line dasatinib. Haematologica. 2011;96:1457–6.
  • 8. Valent: Severe adverse events associated with the use of second-line BCR/ABL tyrosine kinase inhibitors: Preferential occurrence in patients with comorbidities, Haematologica. 96:1395–1397,2011.
  • 9. Kelly K, Swords R, Mahalingam D, Padmanabhan S, Giles FJ. Serosal inflammation (pleural and pericardial effusions) related to tyrosine kinase inhibitors. Target Oncol. 2009;4(2):99–105.
  • 10. Radaelli F, Bramanti S, Fantini NN, Fabio G, Greco I, Lambertenghi-Deliliers G. Dasatinib-related alveolar pneumonia responsive to corticosteroids. Leuk Lymphoma. 2006;47:1180-1.
  • 11. Krauth MT, Herndlhofer S, Schmook MT, Mitterbauer-Hohendanner G, Schlögl E, Valent P. Extensive pleural and pericardial effusion in chronic myeloid leukemia during treatment with Dasatinib at 100 mg or 50 mg daily. Haematologica. 2011;96(1):163–6.

Simultaneously occurred pleural and pericardial effusion related to dasatinib treatment: A case report

Yıl 2018, Cilt: 2 Sayı: 2, 148 - 150, 01.05.2018
https://doi.org/10.28982/josam.393898

Öz

Dasatinib  is  a  proven  potent  tyrosine  kinase  inhibitor  which  is  used  in  the  newly diagnosed  Philadelphia  Chromosome  (Ph1)   positive  chronic  myeloid  leukemia  (CML)  treatment  when  there  is  no  hematological  and/or  cytogenetic  response  to  imatinib treatment.  Pleural  and  pericardial  effusions  due  to  dasatinib  therapy  may  be  seen  5  to 30  weeks  after  the  onset  of  the  treatment,  but  may  also  develop  at  any  time  interval. Pleural  effusions  are  frequently  bilateral  and  exudative,  and  lymphocyte  cell  dominance is  often  observed . It  has  been  observed  that  when  dasatinib  treatment  is  stopped,  the side  effects  which  occurred  with  the  treatment  are  greatly  regressed.  In  this  article,  we present  a  case  with  New  York  Heart  Association  (NYHA)  functional  class  III  dyspnea under  the  treatment  of  dasatinib  and  developed  simultaneous  pleural  and  pericardial effusion,  which  is  rare  in  the  literature. Our  aim  of  presenting  this  case  is  to  emphasize  once  again  the  rarity  of  simultaneous pleural  and  pericardial  effusion  development  in  dasatinib  therapy,  and  the  importance of  intermittent  cardiopulmonary  evaluation  before  and  during  the  treatment  of  CML patients.

Kaynakça

  • 1. Hillman RS, Ault KA, Leporrier M, Rinder HM. Robert S. Hematology in clinical practice; 5th ed. 2010. pp. 229-245.
  • 2. Dumitrescu D, Seck C, ten Freyhaus H, Gerhardt F, Erdmann E, Rosenkranz S. Fully reversible pulmonar y arterial hypertension associated with dasatinib treatment for chronic myeloid leukaemia. Eur Respir J. 2011;38:218–20.
  • 3. Bergeron A, Rea D, Levy V, Picard C, Meignin V, Tamburini J, et al. Lung abnormalities after dasatinib treatment for chronic myeloid leukemia: a case series. Am J Respir Crit Care Med. 2007;176(8):814–8.
  • 4. Montani D, Bergot E, Günther S, Savale L, Bergeron A, Bourdin A, et al. Pulmonary arterial hypertension in patients treated by dasatinib. Circulation. 2012;125:2128–37.
  • 5. Sillaber C, Herrmann H, Bennett K, Rix U, Baumgartner C, et al. Immunosuppression and atypical infections in CML patients treated with dasatinib at 140 mg daily. Eur J Clin Invest. 2009;39(12):1098–109.
  • 6. Lombardo LJ, Lee FY, Chen P, Norris D, Barrish JC, Behnia K, et al. Discovery of N-(2-chloro-6-methyl-phenyl)-2-(6-(4-[2-hydroxyethyl]-piperazin-1-yl)-2-methylpyrimidin-4-ylamino) thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays. J MedChem. 2004;47:6658–61.
  • 7. Breccia M, Latagliata R, Stagno F, Luciano L, Gozzini A, Castagnetti F, et al. Charlson comorbidity index and adult comorbidity evaluation-27 scores might predict treatment compliance and development of pleural effusions in elderly patients with chronic myeloid leukemia treated with second-line dasatinib. Haematologica. 2011;96:1457–6.
  • 8. Valent: Severe adverse events associated with the use of second-line BCR/ABL tyrosine kinase inhibitors: Preferential occurrence in patients with comorbidities, Haematologica. 96:1395–1397,2011.
  • 9. Kelly K, Swords R, Mahalingam D, Padmanabhan S, Giles FJ. Serosal inflammation (pleural and pericardial effusions) related to tyrosine kinase inhibitors. Target Oncol. 2009;4(2):99–105.
  • 10. Radaelli F, Bramanti S, Fantini NN, Fabio G, Greco I, Lambertenghi-Deliliers G. Dasatinib-related alveolar pneumonia responsive to corticosteroids. Leuk Lymphoma. 2006;47:1180-1.
  • 11. Krauth MT, Herndlhofer S, Schmook MT, Mitterbauer-Hohendanner G, Schlögl E, Valent P. Extensive pleural and pericardial effusion in chronic myeloid leukemia during treatment with Dasatinib at 100 mg or 50 mg daily. Haematologica. 2011;96(1):163–6.
Toplam 11 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular İç Hastalıkları
Bölüm Olgu sunumu
Yazarlar

Burak Bursalı

Serhat Sayın

Ramazan Gökdemir

Yayımlanma Tarihi 1 Mayıs 2018
Yayımlandığı Sayı Yıl 2018 Cilt: 2 Sayı: 2

Kaynak Göster

APA Bursalı, B., Sayın, S., & Gökdemir, R. (2018). Simultaneously occurred pleural and pericardial effusion related to dasatinib treatment: A case report. Journal of Surgery and Medicine, 2(2), 148-150. https://doi.org/10.28982/josam.393898
AMA Bursalı B, Sayın S, Gökdemir R. Simultaneously occurred pleural and pericardial effusion related to dasatinib treatment: A case report. J Surg Med. Mayıs 2018;2(2):148-150. doi:10.28982/josam.393898
Chicago Bursalı, Burak, Serhat Sayın, ve Ramazan Gökdemir. “Simultaneously Occurred Pleural and Pericardial Effusion Related to Dasatinib Treatment: A Case Report”. Journal of Surgery and Medicine 2, sy. 2 (Mayıs 2018): 148-50. https://doi.org/10.28982/josam.393898.
EndNote Bursalı B, Sayın S, Gökdemir R (01 Mayıs 2018) Simultaneously occurred pleural and pericardial effusion related to dasatinib treatment: A case report. Journal of Surgery and Medicine 2 2 148–150.
IEEE B. Bursalı, S. Sayın, ve R. Gökdemir, “Simultaneously occurred pleural and pericardial effusion related to dasatinib treatment: A case report”, J Surg Med, c. 2, sy. 2, ss. 148–150, 2018, doi: 10.28982/josam.393898.
ISNAD Bursalı, Burak vd. “Simultaneously Occurred Pleural and Pericardial Effusion Related to Dasatinib Treatment: A Case Report”. Journal of Surgery and Medicine 2/2 (Mayıs 2018), 148-150. https://doi.org/10.28982/josam.393898.
JAMA Bursalı B, Sayın S, Gökdemir R. Simultaneously occurred pleural and pericardial effusion related to dasatinib treatment: A case report. J Surg Med. 2018;2:148–150.
MLA Bursalı, Burak vd. “Simultaneously Occurred Pleural and Pericardial Effusion Related to Dasatinib Treatment: A Case Report”. Journal of Surgery and Medicine, c. 2, sy. 2, 2018, ss. 148-50, doi:10.28982/josam.393898.
Vancouver Bursalı B, Sayın S, Gökdemir R. Simultaneously occurred pleural and pericardial effusion related to dasatinib treatment: A case report. J Surg Med. 2018;2(2):148-50.