Araştırma Makalesi
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Genel anestezi sırasında preoksijenizasyonda CPAP uygulaması ile indüksiyonda PEEP uygulamasının non-hipoksik apne süresine ve hemodinamik parametrelere etkisi

Yıl 2018, Cilt: 2 Sayı: 3, 310 - 314, 01.09.2018
https://doi.org/10.28982/josam.436032

Öz

Amaç: Bu çalışmada preoksijenizasyonda CPAP ve maske ile ventilasyon sırasında PEEP uygulamanın non-hipoksik apne süresine ve hemodinamik parametrelere etkisi incelenmiştir. Yöntemler: Prospektif randomize çalışmada 100 hasta 4 gruba ayrılmıştır. Grup I ve III’te preoksijenizasyon CPAP maskesiyle uygulanmış ama hastalara basınç uygulanmamış ve indüksiyon sırasında Grup I’de hacim kontrollü ventilasyon (CMV) , Grup III’te ise CMV+6 cmH2O PEEP uygulanmıştır. Grup II ve IV’te ise preoksijenizasyonda CPAP maskesi ile 6 cmH2O basınç uygulanmış; indüksiyon sırasında Grup II’de CMV ile ventilasyon sağlanmış, Grup IV’te ise CMV+6 cmH2O PEEP uyfulanmıştır. Trakeal entübasyondan sonra, tüp havaya açılmış ve hasta spO2 değeri %90’a düşene kadar apneik bırakılmıştır. 

Bulgular: Saturasyonun %90’a düşme süresi Grup IV’te diğer gruplardan anlamlı olarak uzun bulundu. Süreler Grup I’de 412,50±97,37 sn, Grup II’de 443,52±88,84 sn, Grup III’de 415,20±117,45 sn ve Grup IV’de 522,92±83,44 sn şeklinde idi. Tek başına preoksijenizasyonda CPAP veya maske ile ventilasyon sırasında PEEP kullanmanın non-hipoksik apne süresine etkisi olmadığı görüldü.

Sonuç: Özellikle entübasyon güçlüğü düşünülen vakalarda preoksijenizasyon sırasında CPAP ve maske ile ventilasyon sırasında PEEP kullanmak güvenli, basit ve rahat tolere edilen bir yöntemdir ve non-hipoksik apne süresini uzatmaktadır.


Kaynakça

  • 1. Lumb AB. Oxygen. Nunn’s Applied Respiratory Physiology Oxford: Butterworth-Heinmann 2000;288-290.
  • 2. Edmark L, Enlund M, Kostova-Aherdan K, Hedenstierna G. Atelectasis formation and apnoea tolerance after pre-oxygenation with 100%, 80%, or 60% oxygen. Anesthesiology. 2001;95:A1330.
  • 3. Lundquist H, Hedenstierna G, Strandberg A, Tokics L, Brismar B. CT-assessment of dependent lung densities in man during general anaesthesia. Acta Radiologica. 1995;36:626–32.
  • 4. Magnusson L, Spahn DR. New concepts of atelectasis during general anaesthesia. British Journal of Anaesthesia. 2003;91:61–72.
  • 5. Rothen HU, Sporre B, Engberg G, Wegenius G, Reber A, Hedenstierna G. Prevention of atelectasis during general anaesthesia. Lancet. 1995;345:1387–91.
  • 6. Joyce CJ, Wıllıams AB. Kinetics of absorption atelectasis during anesthesia: a mathematical model. J Appl Physiol. 1999;86:1116-25.
  • 7. Rusca M, Wicky S, Proietti S. Continuous positive airways pressure prevents atelectasis formation during induction of general anaesthesia. Anesthesiology. 2001;95:AI33I.
  • 8. Rusca M, Proietti S, Schnyder P, Frascarolo P, Hedenstierna G, Spahn DR, Magnusson L. Prevention of atelectasis formation during induction of general anesthesia. Anesthesia & Analgesia. 2003;97:1835–9.
  • 9. Herriger A, Frascarolo Ph, Spahn DR, Magnusson L. The effect of positive airway pressure during pre-oxygenation and induction of anaesthesia upon duration of non-hypoxic apnoea. Anaesthesia. 2004;59:243–47.
  • 10. Gander S, Frascarolo P, Suter M, Spahn D.R, Magnusson L. Positive end-expiratory pressure during induction of general anesthesia increases duration of nonhypoxic apnea in morbidly obese patients. Anesth Analg. 2005;100:580–4
  • 11. Hedenstierna G, Tokics L, Strandberg A, Lundquist H, Brismar B. Correlation of gas exchange impairment to development of atelectasis during anaesthesia and muscle paralysis. Ada Anaesthesiol Scand. 1986;30:183-91.
  • 12. Nunn JF. Factors influencing the arterial oxygen tension during halothane anaesthesia with spontaneous respiration. British Journal of Anaesthesia. 1964;36:327–41.
  • 13. Bendixen HH, Hedley-White J, Laver MB. Impaired oxygenation in surgical patients during general anesthesia with controlled ventilation. A concept of atelectasis. N Engl J Med. 1963;269:991-6
  • 14. Nyman G, Funkquist B, Kvart C, et al. Atelectasis causes gas exchange impairment in the anaesthetised horse. Equine Vet J. 1990;22:317-24.
  • 15. Duggan M, Kavanagh BP. Pulmonary Atelectasis A Pathogenic Perioperative Entity Anesthesiology. 2005;102:838–54.
  • 16. Reber A, Engberg G, Wegenius G, Hedenstierna G. Lung aeration. The effect of pre-oxygenation and hyperoxygenation during total intravenous anaesthesia. Anaesthesia. 1996;51:733-7.
  • 17. Baraka A. Routine preoxygenation. Anesthesia. 2006;61:612-3.
  • 18. Kung MC, Hung CT, Ng KP. Arterial desaturation during induction in healty adults: should preoxygenation be a routine? Anesth Intens Care. 1991;19:192-6.
  • 19. Bell MDD. Routine preoxygenation- a new ‘minimum standard of care’. Anaesthesia. 2004;59:943–5.
  • 20. Saunders RA, Milner AD, Hopkins IE. The effects of CPAP on lung mechanics and lung volumes in the neonate. Biol Neonate. 1976;29:178-84.
  • 21. Ahumada CA, Goldsmith JP. Continuous Distending pressure. In: Goldsmith JP, Karotkin EH, editors. Philadelphia: Assisted Ventilation of the Neonate. WB Saunders: p. 151-166.
  • 22. Lawson EE, Birdwell RL, Huang PS. Augmentation of pulmonary surfactant secretion by lung expansion at birth. Pediatr Res. 1979;13:611-4.
  • 23. Benumof J. Preoxygenation: best method for both efficacy and efficiency. Anesthesiology. 1999;9:603–5.
  • 24. Reynolds S, Heffner J. Airway management of the critically ill patient: rapid-sequence intubation. Chest. 2005;127:1397–412.
  • 25. Venkateswaran R, Goneppanavar U, Frenny AP. Preoxygenation with 208 head-up tilt provides longer duration of non-hypoxic apnea than conventional preoxygenationin non-obese healthy adults. J Anesth. 2011;25:189–94.
  • 26. Cressey DM, Berthoud M. C, Reilly CS. Effectiveness of continuous positive airway pressure to enhance pre-oxygenation in morbidly obese women. Anaesthesia. 2001;56:670-689.
  • 27. Xue FS, Huang YG, Tong SY, et al. A comparative study of early postoperative hypoxemia in infants, children, and adults undergoing elective plastic surgery. Anesth Analg. 1996;83:709-15.
  • 28. Rothen HU, Sporre B, Engberg G,Wegenius G, Hedenstierna G. Re-expansion of atelectasis during general anesthesia: A computed tomography study. Br J Anaesth. 1993;71:788-95.
  • 29. Tusman G, Böhm SH, Vazquez de Anda GF, Campo JL, Lachmann B. Alveolar recruitment strategy improves arterial oxygenation during general anesthesia. BJA. 1999;82(1):8-13.
  • 30. Neumann P, Rothen HU, Berglund JE, Valtysson J, Magnusson A, Hedenstıerna G. Positive end-expiratory pressure prevents atelectasis during general anaesthesia even in the presence of a high inspired oxygen concentration. Acta Anaesthesiol Scand. 1999;43:295–301.

The effect of CPAP during preoxygenation and PEEP during induction upon the duration of non-hypoxic apnea and hemodynamic parameters

Yıl 2018, Cilt: 2 Sayı: 3, 310 - 314, 01.09.2018
https://doi.org/10.28982/josam.436032

Öz

Aim: This study evaluated the effects of applying CPAP during preoxygenation and PEEP during mask ventilation upon the duration of non-hypoxic apnea and hemodynamic parameters. 

Methods: This prospective randomized study included 100 patients allocated to 4 groups. In Groups I and III, preoxygenation was applied with CPAP mask without any pressure and during induction ventilation was performed with volume-controlled ventilation (CMV) in Group I and CMV + 6 cm H2O PEEP in Group III. In Groups II and IV, preoxygenation was applied with CPAP mask with 6 cmH2O pressure and during induction; ventilation was performed with CMV in Group II and CMV + 6 cm H2O PEEP in Group IV. After tracheal intubation, the tube was left open to air and the patient remained apneic until SpO2 reached 90%. 

Results: The time for SpO2 to reach 90% is significantly longer in Group IV compared to the other groups. The durations were 412.50±97.37 sec in Group I, 443.52±88.84 sec in Group II, 415.20±117.45 sec in Group III and 522.92±83.44 sec in Group IV. Using only CPAP during preoxygenation and only PEEP during mask ventilation had no significant effect on duration of non-hypoxic apnea. 

Conclusion: Especially for patients with difficult intubation, application of CPAP during preoxygenation followed with PEEP during mask ventilation safe, simple and it prolongs non-hypoxic apnea period.


Kaynakça

  • 1. Lumb AB. Oxygen. Nunn’s Applied Respiratory Physiology Oxford: Butterworth-Heinmann 2000;288-290.
  • 2. Edmark L, Enlund M, Kostova-Aherdan K, Hedenstierna G. Atelectasis formation and apnoea tolerance after pre-oxygenation with 100%, 80%, or 60% oxygen. Anesthesiology. 2001;95:A1330.
  • 3. Lundquist H, Hedenstierna G, Strandberg A, Tokics L, Brismar B. CT-assessment of dependent lung densities in man during general anaesthesia. Acta Radiologica. 1995;36:626–32.
  • 4. Magnusson L, Spahn DR. New concepts of atelectasis during general anaesthesia. British Journal of Anaesthesia. 2003;91:61–72.
  • 5. Rothen HU, Sporre B, Engberg G, Wegenius G, Reber A, Hedenstierna G. Prevention of atelectasis during general anaesthesia. Lancet. 1995;345:1387–91.
  • 6. Joyce CJ, Wıllıams AB. Kinetics of absorption atelectasis during anesthesia: a mathematical model. J Appl Physiol. 1999;86:1116-25.
  • 7. Rusca M, Wicky S, Proietti S. Continuous positive airways pressure prevents atelectasis formation during induction of general anaesthesia. Anesthesiology. 2001;95:AI33I.
  • 8. Rusca M, Proietti S, Schnyder P, Frascarolo P, Hedenstierna G, Spahn DR, Magnusson L. Prevention of atelectasis formation during induction of general anesthesia. Anesthesia & Analgesia. 2003;97:1835–9.
  • 9. Herriger A, Frascarolo Ph, Spahn DR, Magnusson L. The effect of positive airway pressure during pre-oxygenation and induction of anaesthesia upon duration of non-hypoxic apnoea. Anaesthesia. 2004;59:243–47.
  • 10. Gander S, Frascarolo P, Suter M, Spahn D.R, Magnusson L. Positive end-expiratory pressure during induction of general anesthesia increases duration of nonhypoxic apnea in morbidly obese patients. Anesth Analg. 2005;100:580–4
  • 11. Hedenstierna G, Tokics L, Strandberg A, Lundquist H, Brismar B. Correlation of gas exchange impairment to development of atelectasis during anaesthesia and muscle paralysis. Ada Anaesthesiol Scand. 1986;30:183-91.
  • 12. Nunn JF. Factors influencing the arterial oxygen tension during halothane anaesthesia with spontaneous respiration. British Journal of Anaesthesia. 1964;36:327–41.
  • 13. Bendixen HH, Hedley-White J, Laver MB. Impaired oxygenation in surgical patients during general anesthesia with controlled ventilation. A concept of atelectasis. N Engl J Med. 1963;269:991-6
  • 14. Nyman G, Funkquist B, Kvart C, et al. Atelectasis causes gas exchange impairment in the anaesthetised horse. Equine Vet J. 1990;22:317-24.
  • 15. Duggan M, Kavanagh BP. Pulmonary Atelectasis A Pathogenic Perioperative Entity Anesthesiology. 2005;102:838–54.
  • 16. Reber A, Engberg G, Wegenius G, Hedenstierna G. Lung aeration. The effect of pre-oxygenation and hyperoxygenation during total intravenous anaesthesia. Anaesthesia. 1996;51:733-7.
  • 17. Baraka A. Routine preoxygenation. Anesthesia. 2006;61:612-3.
  • 18. Kung MC, Hung CT, Ng KP. Arterial desaturation during induction in healty adults: should preoxygenation be a routine? Anesth Intens Care. 1991;19:192-6.
  • 19. Bell MDD. Routine preoxygenation- a new ‘minimum standard of care’. Anaesthesia. 2004;59:943–5.
  • 20. Saunders RA, Milner AD, Hopkins IE. The effects of CPAP on lung mechanics and lung volumes in the neonate. Biol Neonate. 1976;29:178-84.
  • 21. Ahumada CA, Goldsmith JP. Continuous Distending pressure. In: Goldsmith JP, Karotkin EH, editors. Philadelphia: Assisted Ventilation of the Neonate. WB Saunders: p. 151-166.
  • 22. Lawson EE, Birdwell RL, Huang PS. Augmentation of pulmonary surfactant secretion by lung expansion at birth. Pediatr Res. 1979;13:611-4.
  • 23. Benumof J. Preoxygenation: best method for both efficacy and efficiency. Anesthesiology. 1999;9:603–5.
  • 24. Reynolds S, Heffner J. Airway management of the critically ill patient: rapid-sequence intubation. Chest. 2005;127:1397–412.
  • 25. Venkateswaran R, Goneppanavar U, Frenny AP. Preoxygenation with 208 head-up tilt provides longer duration of non-hypoxic apnea than conventional preoxygenationin non-obese healthy adults. J Anesth. 2011;25:189–94.
  • 26. Cressey DM, Berthoud M. C, Reilly CS. Effectiveness of continuous positive airway pressure to enhance pre-oxygenation in morbidly obese women. Anaesthesia. 2001;56:670-689.
  • 27. Xue FS, Huang YG, Tong SY, et al. A comparative study of early postoperative hypoxemia in infants, children, and adults undergoing elective plastic surgery. Anesth Analg. 1996;83:709-15.
  • 28. Rothen HU, Sporre B, Engberg G,Wegenius G, Hedenstierna G. Re-expansion of atelectasis during general anesthesia: A computed tomography study. Br J Anaesth. 1993;71:788-95.
  • 29. Tusman G, Böhm SH, Vazquez de Anda GF, Campo JL, Lachmann B. Alveolar recruitment strategy improves arterial oxygenation during general anesthesia. BJA. 1999;82(1):8-13.
  • 30. Neumann P, Rothen HU, Berglund JE, Valtysson J, Magnusson A, Hedenstıerna G. Positive end-expiratory pressure prevents atelectasis during general anaesthesia even in the presence of a high inspired oxygen concentration. Acta Anaesthesiol Scand. 1999;43:295–301.
Toplam 30 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Cerrahi
Bölüm Araştırma makalesi
Yazarlar

Havva Esra Uyar Türkyılmaz

Asutay Göktuğ

Selçuk Tur Bu kişi benim

Hülya Başar Bu kişi benim

Yayımlanma Tarihi 1 Eylül 2018
Yayımlandığı Sayı Yıl 2018 Cilt: 2 Sayı: 3

Kaynak Göster

APA Uyar Türkyılmaz, H. E., Göktuğ, A., Tur, S., Başar, H. (2018). The effect of CPAP during preoxygenation and PEEP during induction upon the duration of non-hypoxic apnea and hemodynamic parameters. Journal of Surgery and Medicine, 2(3), 310-314. https://doi.org/10.28982/josam.436032
AMA Uyar Türkyılmaz HE, Göktuğ A, Tur S, Başar H. The effect of CPAP during preoxygenation and PEEP during induction upon the duration of non-hypoxic apnea and hemodynamic parameters. J Surg Med. Eylül 2018;2(3):310-314. doi:10.28982/josam.436032
Chicago Uyar Türkyılmaz, Havva Esra, Asutay Göktuğ, Selçuk Tur, ve Hülya Başar. “The Effect of CPAP During Preoxygenation and PEEP During Induction Upon the Duration of Non-Hypoxic Apnea and Hemodynamic Parameters”. Journal of Surgery and Medicine 2, sy. 3 (Eylül 2018): 310-14. https://doi.org/10.28982/josam.436032.
EndNote Uyar Türkyılmaz HE, Göktuğ A, Tur S, Başar H (01 Eylül 2018) The effect of CPAP during preoxygenation and PEEP during induction upon the duration of non-hypoxic apnea and hemodynamic parameters. Journal of Surgery and Medicine 2 3 310–314.
IEEE H. E. Uyar Türkyılmaz, A. Göktuğ, S. Tur, ve H. Başar, “The effect of CPAP during preoxygenation and PEEP during induction upon the duration of non-hypoxic apnea and hemodynamic parameters”, J Surg Med, c. 2, sy. 3, ss. 310–314, 2018, doi: 10.28982/josam.436032.
ISNAD Uyar Türkyılmaz, Havva Esra vd. “The Effect of CPAP During Preoxygenation and PEEP During Induction Upon the Duration of Non-Hypoxic Apnea and Hemodynamic Parameters”. Journal of Surgery and Medicine 2/3 (Eylül 2018), 310-314. https://doi.org/10.28982/josam.436032.
JAMA Uyar Türkyılmaz HE, Göktuğ A, Tur S, Başar H. The effect of CPAP during preoxygenation and PEEP during induction upon the duration of non-hypoxic apnea and hemodynamic parameters. J Surg Med. 2018;2:310–314.
MLA Uyar Türkyılmaz, Havva Esra vd. “The Effect of CPAP During Preoxygenation and PEEP During Induction Upon the Duration of Non-Hypoxic Apnea and Hemodynamic Parameters”. Journal of Surgery and Medicine, c. 2, sy. 3, 2018, ss. 310-4, doi:10.28982/josam.436032.
Vancouver Uyar Türkyılmaz HE, Göktuğ A, Tur S, Başar H. The effect of CPAP during preoxygenation and PEEP during induction upon the duration of non-hypoxic apnea and hemodynamic parameters. J Surg Med. 2018;2(3):310-4.