Sağlıklı Erişkinlerde İstirahat Kalp Hızı Oksidatif Stresle İlişkili Değildir

Yıl 2019, Cilt: 22 Sayı: 1, 20 - 24, 11.04.2019

Sadettin Selçuk Baysal

Öz

Giriş: Her ne kadar istirahat kalp hızı (İKH) ve oksidatif stres, kardiyovasküler morbidite ve mortalite için
risk faktörleri olsa da bunlar arasındaki ilişki tam olarak anlaşılamamıştır. Bu çalışmamızda, İKH ile oksidatif/
antioksidatif stres belirteçleri arasındaki ilişkiyi araştırmayı amaçladık.
Hastalar ve Yöntem: Çalışma 56 sağlıklı gönüllüden (33 erkek; ortalama yaş: 44.1 ± 9.0 yıl) oluşmaktaydı.
Gönüllüler kalp hızı çeyrekliklerine göre iki gruba bölündüler: alt iki çeyreklik grup 1 (n= 29) ve üst iki
çeyreklik grup 2 (n= 27). Hastaların total oksidan kapasitesi (TOK), total antioksidan kapasitesi (TAK),
oksidatif stres indeksi (OSİ) ve serum seruloplasmin düzeylerini ölçük.
Bulgular: Bazal klinik karakteristikler ve laboratuvar ölçümleri açısında iki grup arasında önemli bir fark
yoktu (p> 0.05 tüm değişkenler için). Ortalama İKH grup 1᾽de 71.3 ± 4.6 iken grup 2᾽de 82.4 ± 4.1 idi. TOK,
TAK, OSİ ve seruloplazmin düzeyleri her iki grupta benzerdi (p> 0.05 tüm değişkenler için). İKH ve oksidatif/antioksidatif stres parametreleri arasında anlamlı bir ilişki saptayamadık.
Sonuç: Çalışmamızda İKH, TOK, TAK, OSİ ve seruloplazmin düzeyleri ile ilişkili bulunmadı.

Anahtar Kelimeler

İstirahat kalp hızı, oksidatif stres, total oksidan kapasitesi, total antioksidan kapasitesi, oksidatif stres indeksi, seruloplazmin

Resting Heart Rate is Not Associated with Oxidative Stress in Healthy Adults

Öz

Introduction: Although resting heart rate (RHR) and oxidative stress are risk factors for cardiovascular
morbidity and mortality, the association between them has not been fully understood. The aim of the present
study was to investigate the relationship between RHR and oxidative/antioxidative stress markers.
Patients and Methods: The study consisted of 56 healthy volunteers (33 males; mean age: 44.1 ± 9.0 years).
Subjects were divided into two groups according to heart rate quartiles: lower two quartiles as group 1 (n= 29)
and upper two quartiles as group 2 (n= 27). We measured total oxidant status (TOS), total antioxidant capacity
(TAC), oxidative stress index (OSI), and ceruloplasmin (CP) levels of subjects.
Results: There was no any significant difference in baseline clinical characteristics and laboratory
measurements between the groups (p> 0.05 for all variables). Mean RHRs were 71.3 ± 4.6 in group 1 and 82.4
± 4.1 in group 2. The TAC, TOS, OSI, and CP levels were similar between the two groups (p> 0.05 for all
variables). We did not detect any significant association between RHR and oxidative/antioxidative parameters.
Conclusion: RHR was not associated with TOS, TAC, OSI, and CP levels in our study. 

Anahtar Kelimeler

Resting heart rate, oxidative stress, total oxidant status, total antioxidant status, oxidative stress index, ceruloplasmin

Kaynakça

• 1. Tverdal A, Hjellvik V, Selmer R. Heart rate and mortality from cardiovascular causes: a 12 year follow-up study of 379 843 men and women aged 40-45 years. Eur Heart J 2008;29:2772-81.
• 2. Kristal-Boneh E, Silber H, Harari G, Froom P. The association of resting heart rate with cardiovascular, cancer and all-cause mortality. Eight year follow-up of 3527 male Israeli employees (the CORDIS Study). Eur Heart J 2000;21:116-24.
• 3. Jensen MT, Marott JL, Allin KH, Nordestgaard BG, Jensen GB. Resting heart rate is associated with cardiovascular and all-cause mortality after adjusting for inflammatory markers: the Copenhagen City Heart Study. Eur J Prev Cardiol 2012;19:102-8.
• 4. Johansen CD, Olsen RH, Pedersen LR, Kumarathurai P, Mouridsen MR, Binici Z, et al. Resting, night-time, and 24 h heart rate as markers of cardiovascular risk in middle-aged and elderly men and women with no apparent heart disease. Eur Heart J 2013; 34:1732-9.
• 5. Lee DH, de Rezende LFM, Hu FB, Jeon JY, Giovannucci EL. Resting heart rate and risk of type 2 diabetes: a prospective cohort study and meta-analysis. Diabetes Metab Res Rev 2019:e3095.
• 6. Giannoglou GD, Chatzizisis YS, Zamboulis C, Parcharidis GE, Mikhailidis DP, Louridas GE. Elevated heart rate and atherosclerosis: an overview of the pathogenetic mechanisms. Int J Cardiol 2008;126:302-12.
• 7. Beere PA, Glagov S, Zarins CK. Experimental atherosclerosis at the carotid bifurcation of the cynomolgus monkey. Localization, compensatory enlargement, and the sparing effect of lowered heart rate. Arterioscler Thromb 1992;12:1245-53.
• 8. Opdahl A, Venkatesh BA, Fernandes VR, Wu CO, Nasir K, Choi EY, et al. Resting heart rate as predictor for left ventricular dysfunction and heart failure: MESA (Multi-Ethnic Study of Atherosclerosis). J Am Coll Cardiol 2014;63:1182-9.
• 9. Simula S, Vanninen E, Lehto S, Hedman A, Pajunen P, Syvänne M, et al. Heart rate variability associates with asymptomatic coronary atherosclerosis. Clin Auton Res 2014;24:31-7.
• 10. Fox K, Ford I, Steg PG, Tendera M, Robertson M, Ferrari R. Heart rate as a prognostic risk factor in patients with coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): a subgroup analysis of a randomised controlled trial. Lancet 2008;372:817-21.
• 11. Beere PA, Glagov S, Zarins CK. Retarding effect of lowered heart rate on coronary atherosclerosis. Science 1984;226:180-3.
• 12. Baumhäkel M, Custodis F, Schlimmer N, Laufs U, Böhm M. Heart rate reduction with ivabradine improves erectile dysfunction in parallel to decrease in atherosclerotic plaque load in ApoE-knockout mice. Atherosclerosis 2010;212:55-62.
• 13. Sezen Y, Bas M, Polat M, Yildiz A, Buyukhatipoglu H, Kucukdurmaz Z, et al. The relationship between oxidative stress and coronary artery ectasia. Cardiol J 2010;17:488-94.
• 14. Öztaş E, Özler S, Ergin M, Erel Ö, Güler B, Çağlar AT, et al. Decreased oxidative stress may contribute to the disease process in placenta accreta. Turk J Med Sci 2017;47:1180-4.
• 15. Özcan O, Erdal H, Çakırca G, Yönden Z. Oxidative stress and its impacts on intracellular lipids, proteins and DNA. J Clin Exp Invest 2015;6:331-6.
• 16. Custodis F, Baumhäkel M, Schlimmer N, List F, Gensch C, Böhm M, et al. Heart rate reduction by ivabradine reduces oxidative stress, improves endothelial function, and prevents atherosclerosis in apolipoprotein E–deficient mice. Circulation 2008;117:2377-87.
• 17. Carlson N, Dixen U, Marott JL, Jensen MT, Jensen GB. Predictive value of casual ECG-based resting heart rate compared with resting heart rate obtained from Holter recording. Scand J Clin Lab Invest 2014;74:163-9.
• 18. Erel O. A novel automated method to measure total antioxidant response against potent free radical reactions. Clin Biochem 2004;37:112-9.
• 19. Erel O. A new automated colorimetric method for measuring total oxidant status. Clin Biochem 2005;38:1103-11.
• 20. Palatini P, Thijs L, Staessen JA, Fagard RH, Bulpitt CJ, Clement DL, et al. Predictive value of clinic and ambulatory heart rate for mortality in elderly subjects with systolic hypertension. Arch Intern Med 2002;162:2313-21.
• 21. Franklin BA, Chaddha A. Resting heart rate and blood pressure as indices of cardiovascular and mortality risk: is lower invariably better? J Cardiopulm Rehabil Prev 2018;38:353-7.
• 22. Stone PH, Coskun AU, Yeghiazarians Y, Kinlay S, Popma JJ, Kuntz RE, et al. Prediction of sites of coronary atherosclerosis progression: in vivo profiling of endothelial shear stress, lumen, and outer vessel wall characteristics to predict vascular behavior. Curr Opin Cardiol 2003;18:458-70.
• 23. Chatzizisis YS, Coskun AU, Jonas M, Edelman ER, Feldman CL, Stone PH. Role of endothelial shear stress in the natural history of coronary atherosclerosis and vascular remodeling: molecular, cellular, and vascular behavior. J Am Coll Cardiol 2007;49:2379-93.