Sugammadeks

Yıl 2015, Cilt: 16 Sayı: 4, 273 - 278, 31.03.2016

Tayfun Et

Öz

Genel anestezide steroid yapıdaki nöromüsküler bloker ajanlar (NMBA); hızlı ve kolay endotrakeal entübasyon ve ventilasyon uygulamasındaki etkilerinden dolayı kullanımı artmaktadır. NMBA’ın kullanımından kaynaklanan postoperatif rezidüel blok; hipoventilasyon, havayolu obstrüksiyonu, hipoksi ve ölüm gibi komplikasyonlara neden olmaktadır. Sugammadeks steroid yapıda NMBA’ın etkisini geri çeviren, gamma-siklodektrin yapıda ve sekiz glukoz molekülü içeren ilk seçici bağlayıcı ajandır. Sugammadeks uygulamasının kolay, etkisinin yüksek ve hızlı olması ve yan etkisinin az olması sebebiyle kullanımı yaygınlaşmaktadır. Sugammadeksin yapısı, uygulama dozu, yan etkisi ve terapotik etkisi hakkında bilği vermeyi amaçladık.

Anahtar Kelimeler

Nöromüsküler bloker, postoperatif rezidüel blok, sugammadeks

Kaynakça

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