Deneysel Şizofreni Modelleri

Yıl 2015, Cilt: 1 Sayı: 1, 12 - 20, 30.09.2015

Oğuz Mutlu Havva Kaya

https://doi.org/10.30934/kusbed.349516

Öz

Şizofreni deney hayvanlarında gerçek anlamda modellenemeyen yegane insan hastalığı olarak tartışılabilir. Deney
hayvanlarında insanlardaki gibi düşüncenin konuşularak ifade edilmesi yeteneği olmaması araştırmalar için gerekli
yeterliliğe sahip bir şizofreni modeli oluşturulmasına engel olmaktadır. Ancak, deney hayvanlarında şizofreninin
fizyopatolojisini ve şizofreni tedavisinde kullanılan veya kullanım potansiyeli olan yeni ilaçların etkilerini
değerlendirmeye olanak veren bazı modeller sınırlı bir yeterlilikle de olsa kullanılmaya çalışılmaktadır. Bunlardan
bazıları lokomosyon ve stereotipi modelleri, koşullanmış sakınma cevabı, katatoni testi, sıçan pençe testi, kendini
uyarma paradigmaları, ürkme refleksinin zayıf bir ön uyarı aracılığı ile inhibisyonu, latent inhibisyon paradigmaları,
rodentlerde sosyal etkileşme testi ile şizofreninin değerlendirilmesi, bilişsel modeller, hücresel ve moleküler
modeller, farmakolojik modeller, gelişimsel modeller, genetik modeller olarak sınıflandırılabilir. 

Anahtar Kelimeler

Şizofreni, hayvan modelleri, antipsikotikler

Experimental Schizophrenia Models

Öz

Schizophrenia is a unique disease which cannot be mimicked exactly in experimental animals. In experimental
animals, the thoughts cannot be explained by talking like in men and this causes it difficult to form a sufficient
schizophrenia model in experimental investigations. However, some models were used to investigate the effects of
new drugs in the therapy of schizophrenia and in the physiopathology of schizophrenia. Some of these models can be
classified as locomotion and stereotype models, conditioned avoidance responding, catalepsy test, rat paw test, selfstimulation
paradigms, prepulse inhibition of the startle reflex, latent inhibition paradigms, evaluating schizophrenia
by social interaction test in rodents, cognitive models, cellular and molecular models, pharmacological models,
developmental models, genetic models. 

Anahtar Kelimeler

Schizophrenia, animal models, antipsychotics

Kaynakça

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